FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297239376> ?p ?o ?g. }

• W4297239376 endingPage "13803" @default.
• W4297239376 startingPage "13795" @default.
• W4297239376 abstract "N-Nitrosamines are strictly regulated in pharmaceutical products due to their carcinogenic nature. Therefore, the ability to rapidly and reliably identify the N-nitroso functionality is urgently needed. Unfortunately, not all ionized N-nitroso compounds produce diagnostic fragment ions and hence tandem mass spectrometry based on collision-activated dissociation (CAD) cannot be used to consistently identify the N-nitroso functionality. Therefore, a more reliable method was developed based on diagnostic functional-group selective ion-molecule reactions in a linear quadrupole ion trap mass spectrometer. 2-Methoxypropene (MOP) was identified as a reagent that reacts with protonated N-nitrosamines in a diagnostic manner by forming an adduct followed by the elimination of 2-propenol (CH3C(OH)═CH2]). From 18 protonated N-nitrosamine model compounds studied, 15 formed the diagnostic product ion. The lack of the diagnostic reaction for three of the N-nitrosamine model compounds was rationalized based on the presence of a pyridine ring that gets preferentially protonated instead of the N-nitroso functionality. These N-nitrosamines can be identified by subjecting a stable adduct formed upon ion-molecule reactions with MOP to CAD. Further, the ability to use ion-molecule reactions followed by CAD to differentiate protonated O-nitroso compounds with a pyridine ring from analogous N-nitrosamines was demonstrated This methodology is considered to be robust for the identification of the N-nitroso functionality in unknown analytes. Lastly, HPLC/MS2 experiments were performed to determine the detection limit for five FDA regulated N-nitrosamines." @default.
• W4297239376 created "2022-09-28" @default.
• W4297239376 creator A5006022521 @default.
• W4297239376 creator A5007607325 @default.
• W4297239376 creator A5026979203 @default.
• W4297239376 creator A5033080900 @default.
• W4297239376 creator A5033427601 @default.
• W4297239376 creator A5036747126 @default.
• W4297239376 creator A5041775270 @default.
• W4297239376 creator A5045732860 @default.
• W4297239376 creator A5055839549 @default.
• W4297239376 creator A5056660920 @default.
• W4297239376 creator A5064528074 @default.
• W4297239376 creator A5077889981 @default.
• W4297239376 creator A5090258758 @default.
• W4297239376 date "2022-09-26" @default.
• W4297239376 modified "2023-09-24" @default.
• W4297239376 title "A Diagnostic Nitrosamine Detection Approach for Pharmaceuticals by Using Tandem Mass Spectrometry Based on Diagnostic Gas-Phase Ion-Molecule Reactions" @default.
• W4297239376 cites W1803969577 @default.
• W4297239376 cites W1947756774 @default.
• W4297239376 cites W1971716915 @default.
• W4297239376 cites W1973547686 @default.
• W4297239376 cites W2034840612 @default.
• W4297239376 cites W2041203635 @default.
• W4297239376 cites W2042375109 @default.
• W4297239376 cites W2058525089 @default.
• W4297239376 cites W2062793967 @default.
• W4297239376 cites W2067363534 @default.
• W4297239376 cites W2068077195 @default.
• W4297239376 cites W2085336624 @default.
• W4297239376 cites W2098066327 @default.
• W4297239376 cites W2142434570 @default.
• W4297239376 cites W2147089941 @default.
• W4297239376 cites W2159410970 @default.
• W4297239376 cites W2415028850 @default.
• W4297239376 cites W2562459253 @default.
• W4297239376 cites W2625978401 @default.
• W4297239376 cites W2901115243 @default.
• W4297239376 cites W3016716265 @default.
• W4297239376 cites W3123877757 @default.
• W4297239376 cites W3132296981 @default.
• W4297239376 cites W3135198452 @default.
• W4297239376 cites W3193334237 @default.
• W4297239376 doi "https://doi.org/10.1021/acs.analchem.2c02282" @default.
• W4297239376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36154017" @default.
• W4297239376 hasPublicationYear "2022" @default.
• W4297239376 type Work @default.
• W4297239376 citedByCount "0" @default.
• W4297239376 crossrefType "journal-article" @default.
• W4297239376 hasAuthorship W4297239376A5006022521 @default.
• W4297239376 hasAuthorship W4297239376A5007607325 @default.
• W4297239376 hasAuthorship W4297239376A5026979203 @default.
• W4297239376 hasAuthorship W4297239376A5033080900 @default.
• W4297239376 hasAuthorship W4297239376A5033427601 @default.
• W4297239376 hasAuthorship W4297239376A5036747126 @default.
• W4297239376 hasAuthorship W4297239376A5041775270 @default.
• W4297239376 hasAuthorship W4297239376A5045732860 @default.
• W4297239376 hasAuthorship W4297239376A5055839549 @default.
• W4297239376 hasAuthorship W4297239376A5056660920 @default.
• W4297239376 hasAuthorship W4297239376A5064528074 @default.
• W4297239376 hasAuthorship W4297239376A5077889981 @default.
• W4297239376 hasAuthorship W4297239376A5090258758 @default.
• W4297239376 hasConcept C108204754 @default.
• W4297239376 hasConcept C114246631 @default.
• W4297239376 hasConcept C145148216 @default.
• W4297239376 hasConcept C155647269 @default.
• W4297239376 hasConcept C162356407 @default.
• W4297239376 hasConcept C178790620 @default.
• W4297239376 hasConcept C185592680 @default.
• W4297239376 hasConcept C198291218 @default.
• W4297239376 hasConcept C2775932965 @default.
• W4297239376 hasConcept C2777395278 @default.
• W4297239376 hasConcept C2779485729 @default.
• W4297239376 hasConcept C2909807293 @default.
• W4297239376 hasConcept C30095370 @default.
• W4297239376 hasConcept C31827203 @default.
• W4297239376 hasConcept C32909587 @default.
• W4297239376 hasConcept C43617362 @default.
• W4297239376 hasConcept C51884965 @default.
• W4297239376 hasConceptScore W4297239376C108204754 @default.
• W4297239376 hasConceptScore W4297239376C114246631 @default.
• W4297239376 hasConceptScore W4297239376C145148216 @default.
• W4297239376 hasConceptScore W4297239376C155647269 @default.
• W4297239376 hasConceptScore W4297239376C162356407 @default.
• W4297239376 hasConceptScore W4297239376C178790620 @default.
• W4297239376 hasConceptScore W4297239376C185592680 @default.
• W4297239376 hasConceptScore W4297239376C198291218 @default.
• W4297239376 hasConceptScore W4297239376C2775932965 @default.
• W4297239376 hasConceptScore W4297239376C2777395278 @default.
• W4297239376 hasConceptScore W4297239376C2779485729 @default.
• W4297239376 hasConceptScore W4297239376C2909807293 @default.
• W4297239376 hasConceptScore W4297239376C30095370 @default.
• W4297239376 hasConceptScore W4297239376C31827203 @default.
• W4297239376 hasConceptScore W4297239376C32909587 @default.
• W4297239376 hasConceptScore W4297239376C43617362 @default.
• W4297239376 hasConceptScore W4297239376C51884965 @default.
• W4297239376 hasFunder F4320332932 @default.
• W4297239376 hasIssue "40" @default.

• next