Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297242304> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4297242304 endingPage "1102" @default.
- W4297242304 startingPage "1093" @default.
- W4297242304 abstract "To treat animal dose-response data exhibiting inverse dose-response behavior with two tumor control probability (TCP) models accounting for tumor hypoxia and re-oxygenation leading to resensitization of the tumor. One of the tested TCP models uses a modified linear-quadratic (LQ) model of cell survival where both α and β radiosensitivities increase in time during the treatment due to re-oxygenation of the hypoxic tumor sub-population. The other TCP model deals with two types of hypoxia-chronic and acute-and accounts for tumor re-sensitization via oxygenation of the chronically hypoxic and fluctuating oxygenation of the acutely hypoxic sub-populations. The two models are fit using the maximum likelihood method to the data of Fowler et al. on mice mammary tumors irradiated to different doses using different fractionated schedules. These data are chosen since as many as five of the dose-response curves show an inverse dose behavior, which is interpreted as due to re-sensitization. The p-values of the fits of both models to the data render them statistically acceptable. A performed comparison test shows that both models describe the data equally well. It is also demonstrated that the most sensitive (oxic) tumor component has no impact on the treatment outcome. The ability of the tested models to predict and describe the impact of re-sensitization on the treatment outcome is thus proven. It is also demonstrated that prolonged treatment schedules can be more beneficial than shorter ones. However, this may be true only for schedules with small number of fractions, i.e. for hypo-fractionated treatments only." @default.
- W4297242304 created "2022-09-28" @default.
- W4297242304 creator A5033583059 @default.
- W4297242304 creator A5043704582 @default.
- W4297242304 creator A5055790933 @default.
- W4297242304 creator A5061746429 @default.
- W4297242304 creator A5081673996 @default.
- W4297242304 date "2022-09-26" @default.
- W4297242304 modified "2023-09-27" @default.
- W4297242304 title "Analysis of tumour dose–response data from animal experiments via two TCP models accounting for tumor hypoxia and resensitization" @default.
- W4297242304 cites W1955500944 @default.
- W4297242304 cites W1979257831 @default.
- W4297242304 cites W1981065559 @default.
- W4297242304 cites W1985894363 @default.
- W4297242304 cites W1991426014 @default.
- W4297242304 cites W2016167585 @default.
- W4297242304 cites W2027652813 @default.
- W4297242304 cites W2029303959 @default.
- W4297242304 cites W2048382566 @default.
- W4297242304 cites W2061633567 @default.
- W4297242304 cites W2077356383 @default.
- W4297242304 cites W2111685034 @default.
- W4297242304 cites W2122971048 @default.
- W4297242304 cites W2123697448 @default.
- W4297242304 cites W2140176810 @default.
- W4297242304 cites W2184797990 @default.
- W4297242304 cites W2199646096 @default.
- W4297242304 cites W2274463904 @default.
- W4297242304 cites W2329546601 @default.
- W4297242304 cites W2511219591 @default.
- W4297242304 cites W3157583906 @default.
- W4297242304 cites W3202288424 @default.
- W4297242304 cites W4236549981 @default.
- W4297242304 cites W4297361535 @default.
- W4297242304 doi "https://doi.org/10.1007/s13246-022-01173-9" @default.
- W4297242304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36156763" @default.
- W4297242304 hasPublicationYear "2022" @default.
- W4297242304 type Work @default.
- W4297242304 citedByCount "0" @default.
- W4297242304 crossrefType "journal-article" @default.
- W4297242304 hasAuthorship W4297242304A5033583059 @default.
- W4297242304 hasAuthorship W4297242304A5043704582 @default.
- W4297242304 hasAuthorship W4297242304A5055790933 @default.
- W4297242304 hasAuthorship W4297242304A5061746429 @default.
- W4297242304 hasAuthorship W4297242304A5081673996 @default.
- W4297242304 hasBestOaLocation W42972423042 @default.
- W4297242304 hasConcept C126322002 @default.
- W4297242304 hasConcept C178790620 @default.
- W4297242304 hasConcept C185592680 @default.
- W4297242304 hasConcept C203014093 @default.
- W4297242304 hasConcept C2776217527 @default.
- W4297242304 hasConcept C2778117688 @default.
- W4297242304 hasConcept C2779081379 @default.
- W4297242304 hasConcept C2908647359 @default.
- W4297242304 hasConcept C509974204 @default.
- W4297242304 hasConcept C540031477 @default.
- W4297242304 hasConcept C70289976 @default.
- W4297242304 hasConcept C71924100 @default.
- W4297242304 hasConcept C7836513 @default.
- W4297242304 hasConcept C99454951 @default.
- W4297242304 hasConceptScore W4297242304C126322002 @default.
- W4297242304 hasConceptScore W4297242304C178790620 @default.
- W4297242304 hasConceptScore W4297242304C185592680 @default.
- W4297242304 hasConceptScore W4297242304C203014093 @default.
- W4297242304 hasConceptScore W4297242304C2776217527 @default.
- W4297242304 hasConceptScore W4297242304C2778117688 @default.
- W4297242304 hasConceptScore W4297242304C2779081379 @default.
- W4297242304 hasConceptScore W4297242304C2908647359 @default.
- W4297242304 hasConceptScore W4297242304C509974204 @default.
- W4297242304 hasConceptScore W4297242304C540031477 @default.
- W4297242304 hasConceptScore W4297242304C70289976 @default.
- W4297242304 hasConceptScore W4297242304C71924100 @default.
- W4297242304 hasConceptScore W4297242304C7836513 @default.
- W4297242304 hasConceptScore W4297242304C99454951 @default.
- W4297242304 hasFunder F4320321843 @default.
- W4297242304 hasIssue "4" @default.
- W4297242304 hasLocation W42972423041 @default.
- W4297242304 hasLocation W42972423042 @default.
- W4297242304 hasLocation W42972423043 @default.
- W4297242304 hasOpenAccess W4297242304 @default.
- W4297242304 hasPrimaryLocation W42972423041 @default.
- W4297242304 hasRelatedWork W2061361188 @default.
- W4297242304 hasRelatedWork W2107838455 @default.
- W4297242304 hasRelatedWork W2153137055 @default.
- W4297242304 hasRelatedWork W2278103592 @default.
- W4297242304 hasRelatedWork W2366279991 @default.
- W4297242304 hasRelatedWork W2480236757 @default.
- W4297242304 hasRelatedWork W2563569367 @default.
- W4297242304 hasRelatedWork W2956377452 @default.
- W4297242304 hasRelatedWork W4297242304 @default.
- W4297242304 hasRelatedWork W4361824506 @default.
- W4297242304 hasVolume "45" @default.
- W4297242304 isParatext "false" @default.
- W4297242304 isRetracted "false" @default.
- W4297242304 workType "article" @default.