FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297243668> ?p ?o ?g. }

• W4297243668 abstract "Abstract The pathophysiology of vision loss and loss of visual field in patients with idiopathic intracranial hypertension with papilloedema is not fully understood. Although elevated CSF pressure induces damage to the optic nerve due to stasis of axoplasmic flow, there is no clear relationship between the severity of papilloedema and CSF pressure. Furthermore, there are cases of purely unilateral papilloedema and cases without papilloedema despite significantly elevated intracranial pressure as well as papilloedema that can persist despite a successfully lowered intracranial pressure. We hypothesize that at least in some of such cases, in addition to purely pressure-induced damage to the optic nerve, the biochemical composition of the CSF in the subarachnoid space surrounding the orbital optic nerve may play a role in the pathogenesis of vision loss. In this retrospective study, we report on lipocalin-type prostaglandin D synthase concentrations in the CSF within the perioptic and lumbar subarachnoid space in 14 patients with idiopathic intracranial hypertension (13 females, mean age 45 ± 13 years) with chronic persistent papilloedema resistant to maximum-tolerated medical therapy and visual impairment. CSF was collected from the subarachnoid space of the optic nerve during optic nerve sheath fenestration and from the lumbar subarachnoid space at the time of lumbar puncture. CSF was analysed for lipocalin-type prostaglandin D synthase and the concentrations compared between the two sites using nephelometry. The mean lipocalin-type prostaglandin D synthase concentration in the perioptic subarachnoid space was significantly higher compared with the concentration in the lumbar subarachnoid space (69 ± 51 mg/l without correction of serum contamination and 89 ± 67 mg/l after correction of serum contamination versus 23 ± 8 mg/l; P &lt; 0.0001, Mann–Whitney U-test). These measurements demonstrate a change and imbalance in the biochemical environment of the optic nerve. Its possible effect is discussed." @default.
• W4297243668 created "2022-09-28" @default.
• W4297243668 creator A5018886788 @default.
• W4297243668 creator A5031384782 @default.
• W4297243668 creator A5035244736 @default.
• W4297243668 creator A5039205073 @default.
• W4297243668 creator A5051466856 @default.
• W4297243668 creator A5062439343 @default.
• W4297243668 creator A5063216533 @default.
• W4297243668 creator A5080723052 @default.
• W4297243668 creator A5083587874 @default.
• W4297243668 creator A5088588339 @default.
• W4297243668 date "2022-09-01" @default.
• W4297243668 modified "2023-09-30" @default.
• W4297243668 title "Elevated perioptic lipocalin-type prostaglandin D synthase concentration in patients with idiopathic intracranial hypertension" @default.
• W4297243668 cites W1978853862 @default.
• W4297243668 cites W1995443384 @default.
• W4297243668 cites W2017888024 @default.
• W4297243668 cites W2019758463 @default.
• W4297243668 cites W2024591795 @default.
• W4297243668 cites W2028933367 @default.
• W4297243668 cites W2030780622 @default.
• W4297243668 cites W2061959584 @default.
• W4297243668 cites W2065496524 @default.
• W4297243668 cites W2070010854 @default.
• W4297243668 cites W2082635345 @default.
• W4297243668 cites W2091800307 @default.
• W4297243668 cites W2092312715 @default.
• W4297243668 cites W2103476922 @default.
• W4297243668 cites W2106431230 @default.
• W4297243668 cites W2111279651 @default.
• W4297243668 cites W2121367632 @default.
• W4297243668 cites W2121506107 @default.
• W4297243668 cites W2127395282 @default.
• W4297243668 cites W2141148854 @default.
• W4297243668 cites W2159830014 @default.
• W4297243668 cites W2170487869 @default.
• W4297243668 cites W2331264136 @default.
• W4297243668 cites W2560261457 @default.
• W4297243668 cites W2791821621 @default.
• W4297243668 cites W2807962932 @default.
• W4297243668 cites W2808698383 @default.
• W4297243668 cites W2971282548 @default.
• W4297243668 cites W3083409664 @default.
• W4297243668 cites W3093041683 @default.
• W4297243668 cites W3156153590 @default.
• W4297243668 cites W3156729389 @default.
• W4297243668 cites W56527255 @default.
• W4297243668 cites W13460065 @default.
• W4297243668 cites W2251137032 @default.
• W4297243668 doi "https://doi.org/10.1093/braincomms/fcac240" @default.
• W4297243668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36262370" @default.
• W4297243668 hasPublicationYear "2022" @default.
• W4297243668 type Work @default.
• W4297243668 citedByCount "3" @default.
• W4297243668 countsByYear W42972436682023 @default.
• W4297243668 crossrefType "journal-article" @default.
• W4297243668 hasAuthorship W4297243668A5018886788 @default.
• W4297243668 hasAuthorship W4297243668A5031384782 @default.
• W4297243668 hasAuthorship W4297243668A5035244736 @default.
• W4297243668 hasAuthorship W4297243668A5039205073 @default.
• W4297243668 hasAuthorship W4297243668A5051466856 @default.
• W4297243668 hasAuthorship W4297243668A5062439343 @default.
• W4297243668 hasAuthorship W4297243668A5063216533 @default.
• W4297243668 hasAuthorship W4297243668A5080723052 @default.
• W4297243668 hasAuthorship W4297243668A5083587874 @default.
• W4297243668 hasAuthorship W4297243668A5088588339 @default.
• W4297243668 hasBestOaLocation W42972436682 @default.
• W4297243668 hasConcept C118487528 @default.
• W4297243668 hasConcept C126322002 @default.
• W4297243668 hasConcept C141071460 @default.
• W4297243668 hasConcept C2777405951 @default.
• W4297243668 hasConcept C2779651940 @default.
• W4297243668 hasConcept C2780066322 @default.
• W4297243668 hasConcept C2780664492 @default.
• W4297243668 hasConcept C2780813603 @default.
• W4297243668 hasConcept C2780837183 @default.
• W4297243668 hasConcept C2780954326 @default.
• W4297243668 hasConcept C42219234 @default.
• W4297243668 hasConcept C44575665 @default.
• W4297243668 hasConcept C71924100 @default.
• W4297243668 hasConceptScore W4297243668C118487528 @default.
• W4297243668 hasConceptScore W4297243668C126322002 @default.
• W4297243668 hasConceptScore W4297243668C141071460 @default.
• W4297243668 hasConceptScore W4297243668C2777405951 @default.
• W4297243668 hasConceptScore W4297243668C2779651940 @default.
• W4297243668 hasConceptScore W4297243668C2780066322 @default.
• W4297243668 hasConceptScore W4297243668C2780664492 @default.
• W4297243668 hasConceptScore W4297243668C2780813603 @default.
• W4297243668 hasConceptScore W4297243668C2780837183 @default.
• W4297243668 hasConceptScore W4297243668C2780954326 @default.
• W4297243668 hasConceptScore W4297243668C42219234 @default.
• W4297243668 hasConceptScore W4297243668C44575665 @default.
• W4297243668 hasConceptScore W4297243668C71924100 @default.
• W4297243668 hasIssue "5" @default.
• W4297243668 hasLocation W42972436681 @default.
• W4297243668 hasLocation W42972436682 @default.
• W4297243668 hasLocation W42972436683 @default.
• W4297243668 hasLocation W42972436684 @default.
• W4297243668 hasOpenAccess W4297243668 @default.

• next