Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297250079> ?p ?o ?g. }
- W4297250079 endingPage "2300" @default.
- W4297250079 startingPage "2287" @default.
- W4297250079 abstract "Brown adipose tissue (BAT) plays an essential role in non-shivering thermogenesis. The phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) is identified as a lipid transporter that reciprocally transfers phospholipids between intracellular membrane structures. However, the physiological significance of PITPNC1 and its regulatory mechanism remain unclear. Here, we demonstrate that PITPNC1 is a key player in thermogenesis of BAT. While Pitpnc1-/- mice do not differ with wildtype mice in body weight and insulin sensitivity on either chow or high-fat diet, they develop hypothermia when subjected to acute cold exposure at 4°C. The Pitpnc1-/- brown adipocytes exhibit defective β-oxidation and abnormal thermogenesis-related metabolism pathways in mitochondria. The deficiency of lipid mobilization in Pitpnc1-/- brown adipocytes might be the result of excessive accumulation of phosphatidylcholine and a reduction of phosphatidic acid. Our findings have uncovered significant roles of PITPNC1 in mitochondrial phospholipid homeostasis and BAT thermogenesis." @default.
- W4297250079 created "2022-09-28" @default.
- W4297250079 creator A5000680684 @default.
- W4297250079 creator A5016315791 @default.
- W4297250079 creator A5027755683 @default.
- W4297250079 creator A5028141192 @default.
- W4297250079 creator A5046537522 @default.
- W4297250079 creator A5048238501 @default.
- W4297250079 creator A5049145772 @default.
- W4297250079 creator A5050727273 @default.
- W4297250079 creator A5062621356 @default.
- W4297250079 creator A5063433481 @default.
- W4297250079 creator A5070778210 @default.
- W4297250079 creator A5071458554 @default.
- W4297250079 creator A5076073241 @default.
- W4297250079 creator A5083798008 @default.
- W4297250079 creator A5084919650 @default.
- W4297250079 date "2022-09-23" @default.
- W4297250079 modified "2023-09-30" @default.
- W4297250079 title "PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure" @default.
- W4297250079 cites W1558355581 @default.
- W4297250079 cites W1964679889 @default.
- W4297250079 cites W1986611140 @default.
- W4297250079 cites W2007270198 @default.
- W4297250079 cites W2031532144 @default.
- W4297250079 cites W2033907674 @default.
- W4297250079 cites W2051444072 @default.
- W4297250079 cites W2068912594 @default.
- W4297250079 cites W2081249929 @default.
- W4297250079 cites W2086029074 @default.
- W4297250079 cites W2086410640 @default.
- W4297250079 cites W2092771390 @default.
- W4297250079 cites W2103042528 @default.
- W4297250079 cites W2104240077 @default.
- W4297250079 cites W2130819897 @default.
- W4297250079 cites W2302425335 @default.
- W4297250079 cites W2346922085 @default.
- W4297250079 cites W2515608087 @default.
- W4297250079 cites W2548393767 @default.
- W4297250079 cites W2561330046 @default.
- W4297250079 cites W2738310514 @default.
- W4297250079 cites W2773801698 @default.
- W4297250079 cites W2779977530 @default.
- W4297250079 cites W2785234547 @default.
- W4297250079 cites W2796174912 @default.
- W4297250079 cites W2885353413 @default.
- W4297250079 cites W2898820146 @default.
- W4297250079 cites W2908238761 @default.
- W4297250079 cites W2910116104 @default.
- W4297250079 cites W2943053066 @default.
- W4297250079 cites W2947535015 @default.
- W4297250079 cites W2963247935 @default.
- W4297250079 cites W2978687867 @default.
- W4297250079 cites W2981549578 @default.
- W4297250079 cites W3006870977 @default.
- W4297250079 cites W3010715222 @default.
- W4297250079 cites W3012252561 @default.
- W4297250079 cites W3034101399 @default.
- W4297250079 cites W3068639962 @default.
- W4297250079 cites W3087320494 @default.
- W4297250079 cites W3094040275 @default.
- W4297250079 cites W3097110002 @default.
- W4297250079 cites W3115641542 @default.
- W4297250079 cites W3120744005 @default.
- W4297250079 cites W3123533113 @default.
- W4297250079 cites W49578837 @default.
- W4297250079 doi "https://doi.org/10.1007/s11427-022-2157-y" @default.
- W4297250079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36166181" @default.
- W4297250079 hasPublicationYear "2022" @default.
- W4297250079 type Work @default.
- W4297250079 citedByCount "0" @default.
- W4297250079 crossrefType "journal-article" @default.
- W4297250079 hasAuthorship W4297250079A5000680684 @default.
- W4297250079 hasAuthorship W4297250079A5016315791 @default.
- W4297250079 hasAuthorship W4297250079A5027755683 @default.
- W4297250079 hasAuthorship W4297250079A5028141192 @default.
- W4297250079 hasAuthorship W4297250079A5046537522 @default.
- W4297250079 hasAuthorship W4297250079A5048238501 @default.
- W4297250079 hasAuthorship W4297250079A5049145772 @default.
- W4297250079 hasAuthorship W4297250079A5050727273 @default.
- W4297250079 hasAuthorship W4297250079A5062621356 @default.
- W4297250079 hasAuthorship W4297250079A5063433481 @default.
- W4297250079 hasAuthorship W4297250079A5070778210 @default.
- W4297250079 hasAuthorship W4297250079A5071458554 @default.
- W4297250079 hasAuthorship W4297250079A5076073241 @default.
- W4297250079 hasAuthorship W4297250079A5083798008 @default.
- W4297250079 hasAuthorship W4297250079A5084919650 @default.
- W4297250079 hasBestOaLocation W42972500791 @default.
- W4297250079 hasConcept C100564792 @default.
- W4297250079 hasConcept C113323301 @default.
- W4297250079 hasConcept C126322002 @default.
- W4297250079 hasConcept C134018914 @default.
- W4297250079 hasConcept C151279926 @default.
- W4297250079 hasConcept C171089720 @default.
- W4297250079 hasConcept C185592680 @default.
- W4297250079 hasConcept C2776909261 @default.
- W4297250079 hasConcept C2777390192 @default.
- W4297250079 hasConcept C2778918659 @default.