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- W4297251514 abstract "Malaria remains the leading cause of parasitic death in the world. Artemisinin resistance is an emerging threat indicating an imminent need for novel combination therapy. Given the key role of mass drug administration, it is pivotal that the safety of anti-malarial drugs is investigated thoroughly prior to widespread use. Cardiotoxicity, most prominently arrhythmic risk, has been a concern for anti-malarial drugs. We clarify the likely underlying mechanisms by which anti-malarial drugs predispose to arrhythmias. These relate to disruption of (1) action potential upstroke due to effects on the sodium currents, (2) action potential repolarisation due to effects on the potassium currents, (3) cellular calcium homeostasis, (4) mitochondrial function and reactive oxygen species production and (5) cardiac fibrosis. Together, these alterations promote arrhythmic triggers and substrates. Understanding these mechanisms is essential to assess the safety of these drugs, stratify patients based on arrhythmic risk and guide future anti-malarial drug development." @default.
- W4297251514 created "2022-09-28" @default.
- W4297251514 creator A5026758655 @default.
- W4297251514 creator A5061606928 @default.
- W4297251514 creator A5074565083 @default.
- W4297251514 creator A5074877506 @default.
- W4297251514 creator A5090125948 @default.
- W4297251514 date "2022-10-20" @default.
- W4297251514 modified "2023-10-16" @default.
- W4297251514 title "Anti‐malarial drugs: Mechanisms underlying their proarrhythmic effects" @default.
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