FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297259467> ?p ?o ?g. }

• W4297259467 endingPage "8327" @default.
• W4297259467 startingPage "8308" @default.
• W4297259467 abstract "Parental care is critical for successful reproduction in mammals. Recent work has implicated the hormone prolactin in regulating male parental behavior, similar to its established role in females. Male laboratory mice show a mating-induced suppression of infanticide (normally observed in virgins) and onset of paternal behavior 2 weeks after mating. Using this model, we sought to investigate how prolactin acts in the forebrain to regulate paternal behavior. First, using c-fos immunoreactivity in prolactin receptor (Prlr) Prlr -IRES-Cre-tdtomato reporter mouse sires, we show that the circuitry activated during paternal interactions contains prolactin-responsive neurons in multiple sites, including the medial preoptic nucleus, bed nucleus of the stria terminalis, and medial amygdala. Next, we deleted Prlr from three prominent cell types found in these regions: glutamatergic, GABAergic, and CaMKIIα. Prlr deletion from CaMKIIα, but not glutamatergic or GABAergic cells, had a profound effect on paternal behavior as none of these KO males completed the pup-retrieval task. Prolactin was increased during mating, but not in response to pups, suggesting that the mating-induced secretion of prolactin is important for establishing the switch from infanticidal to paternal behavior. Pharmacological blockade of prolactin secretion at mating, however, had no effect on paternal behavior. In contrast, suppressing prolactin secretion at the time of pup exposure resulted in failure to retrieve pups, with exogenous prolactin administration rescuing this behavior. Together, our data show that paternal behavior in sires is dependent on basal levels of circulating prolactin acting at the time of interaction with pups, mediated through Prlr on CaMKIIα-expressing neurons. SIGNIFICANCE STATEMENT Parental care is critical for offspring survival. Compared with maternal care, however, the neurobiology of paternal care is less well understood. Here we show that the hormone prolactin, which is most well known for its female-specific role in lactation, has a role in the male brain to promote paternal behavior. In the absence of prolactin signaling specifically during interactions with pups, father mice fail to show normal retrieval behavior of pups. These data demonstrate that prolactin has a similar action in both males and females to promote parental care." @default.
• W4297259467 created "2022-09-28" @default.
• W4297259467 creator A5013110682 @default.
• W4297259467 creator A5080443061 @default.
• W4297259467 creator A5088585334 @default.
• W4297259467 date "2022-09-26" @default.
• W4297259467 modified "2023-10-14" @default.
• W4297259467 title "Prolactin Action Is Necessary for Parental Behavior in Male Mice" @default.
• W4297259467 cites W1556243325 @default.
• W4297259467 cites W1681773783 @default.
• W4297259467 cites W1968228842 @default.
• W4297259467 cites W1971500326 @default.
• W4297259467 cites W1985418863 @default.
• W4297259467 cites W2001363904 @default.
• W4297259467 cites W2002793647 @default.
• W4297259467 cites W2003284649 @default.
• W4297259467 cites W2010495392 @default.
• W4297259467 cites W2012697144 @default.
• W4297259467 cites W2019946631 @default.
• W4297259467 cites W2028303884 @default.
• W4297259467 cites W2029904277 @default.
• W4297259467 cites W2029922574 @default.
• W4297259467 cites W2031091121 @default.
• W4297259467 cites W2044806898 @default.
• W4297259467 cites W2061072142 @default.
• W4297259467 cites W2070626104 @default.
• W4297259467 cites W2079204610 @default.
• W4297259467 cites W2087453951 @default.
• W4297259467 cites W2104135721 @default.
• W4297259467 cites W2121311726 @default.
• W4297259467 cites W2122767257 @default.
• W4297259467 cites W2137478811 @default.
• W4297259467 cites W2144999736 @default.
• W4297259467 cites W2272805724 @default.
• W4297259467 cites W2346578806 @default.
• W4297259467 cites W2518153053 @default.
• W4297259467 cites W2551929191 @default.
• W4297259467 cites W2560473817 @default.
• W4297259467 cites W2606912748 @default.
• W4297259467 cites W2756432299 @default.
• W4297259467 cites W2883010495 @default.
• W4297259467 cites W2888880619 @default.
• W4297259467 cites W2914152754 @default.
• W4297259467 cites W2939736542 @default.
• W4297259467 cites W2964778500 @default.
• W4297259467 cites W2993720375 @default.
• W4297259467 cites W2996095329 @default.
• W4297259467 cites W3003464706 @default.
• W4297259467 cites W3010051826 @default.
• W4297259467 cites W3040142746 @default.
• W4297259467 cites W3047498213 @default.
• W4297259467 cites W3082755125 @default.
• W4297259467 cites W3120929488 @default.
• W4297259467 cites W3187803157 @default.
• W4297259467 cites W3196616240 @default.
• W4297259467 cites W827881036 @default.
• W4297259467 doi "https://doi.org/10.1523/jneurosci.0558-22.2022" @default.
• W4297259467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36163141" @default.
• W4297259467 hasPublicationYear "2022" @default.
• W4297259467 type Work @default.
• W4297259467 citedByCount "8" @default.
• W4297259467 countsByYear W42972594672023 @default.
• W4297259467 crossrefType "journal-article" @default.
• W4297259467 hasAuthorship W4297259467A5013110682 @default.
• W4297259467 hasAuthorship W4297259467A5080443061 @default.
• W4297259467 hasAuthorship W4297259467A5088585334 @default.
• W4297259467 hasBestOaLocation W42972594671 @default.
• W4297259467 hasConcept C126322002 @default.
• W4297259467 hasConcept C134018914 @default.
• W4297259467 hasConcept C170493617 @default.
• W4297259467 hasConcept C2779064019 @default.
• W4297259467 hasConcept C2779144063 @default.
• W4297259467 hasConcept C2780648746 @default.
• W4297259467 hasConcept C2781031661 @default.
• W4297259467 hasConcept C514575182 @default.
• W4297259467 hasConcept C54355233 @default.
• W4297259467 hasConcept C61174792 @default.
• W4297259467 hasConcept C71315377 @default.
• W4297259467 hasConcept C71924100 @default.
• W4297259467 hasConcept C86803240 @default.
• W4297259467 hasConceptScore W4297259467C126322002 @default.
• W4297259467 hasConceptScore W4297259467C134018914 @default.
• W4297259467 hasConceptScore W4297259467C170493617 @default.
• W4297259467 hasConceptScore W4297259467C2779064019 @default.
• W4297259467 hasConceptScore W4297259467C2779144063 @default.
• W4297259467 hasConceptScore W4297259467C2780648746 @default.
• W4297259467 hasConceptScore W4297259467C2781031661 @default.
• W4297259467 hasConceptScore W4297259467C514575182 @default.
• W4297259467 hasConceptScore W4297259467C54355233 @default.
• W4297259467 hasConceptScore W4297259467C61174792 @default.
• W4297259467 hasConceptScore W4297259467C71315377 @default.
• W4297259467 hasConceptScore W4297259467C71924100 @default.
• W4297259467 hasConceptScore W4297259467C86803240 @default.
• W4297259467 hasFunder F4320335369 @default.
• W4297259467 hasIssue "44" @default.
• W4297259467 hasLocation W42972594671 @default.
• W4297259467 hasLocation W42972594672 @default.
• W4297259467 hasLocation W42972594673 @default.

• next