FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297260103> ?p ?o ?g. }

• W4297260103 endingPage "268" @default.
• W4297260103 startingPage "258" @default.
• W4297260103 abstract "The membrane-based purinergic 7 receptor (P2X 7 R) is expressed on activated microglia and the target of the radioligand [ 11 C]SMW139 for in vivo assessment of neuroinflammation. This study investigated the contribution of radiolabelled metabolites which potentially affect its quantification. Ex vivo high-performance liquid chromatography with a radio detector (radioHPLC) was used to evaluate the parent and radiometabolite fractions of [ 11 C]SMW139 in the brain and plasma of eleven mice. Twelve healthy humans underwent 90-min [ 11 C]SMW139 brain PET with arterial blood sampling and radiometabolite analysis. The volume of distribution was estimated by using one- and two- tissue compartment (TCM) modeling with single ( V T ) and dual ( V Tp ) input functions. RadioHPLC showed three major groups of radiometabolite peaks with increasing concentrations in the plasma of all mice and humans. Two radiometabolite peaks were also visible in mice brain homogenates and therefore considered for dual input modeling in humans. 2TCM with single input function provided V T estimates with a wide range (0.10–10.74) and high coefficient of variation (COV: 159.9%), whereas dual input function model showed a narrow range of V Tp estimates (0.04–0.24; COV: 33.3%). In conclusion, compartment modeling with correction for brain-penetrant radiometabolites improves the in vivo quantification of [ 11 C]SMW139 binding to P2X 7 R in the human brain." @default.
• W4297260103 created "2022-09-28" @default.
• W4297260103 creator A5003445744 @default.
• W4297260103 creator A5019976313 @default.
• W4297260103 creator A5026942684 @default.
• W4297260103 creator A5028878666 @default.
• W4297260103 creator A5037191547 @default.
• W4297260103 creator A5037765698 @default.
• W4297260103 creator A5049341241 @default.
• W4297260103 creator A5051194718 @default.
• W4297260103 creator A5055059044 @default.
• W4297260103 creator A5059258714 @default.
• W4297260103 creator A5061317213 @default.
• W4297260103 creator A5063074613 @default.
• W4297260103 creator A5067273656 @default.
• W4297260103 creator A5069359372 @default.
• W4297260103 creator A5081327813 @default.
• W4297260103 creator A5087888043 @default.
• W4297260103 date "2022-09-26" @default.
• W4297260103 modified "2023-10-01" @default.
• W4297260103 title "Quantification of the purinergic P2X₇ receptor with [¹¹C]SMW139 improves through correction for brain-penetrating radiometabolites" @default.
• W4297260103 cites W1863821458 @default.
• W4297260103 cites W1978289394 @default.
• W4297260103 cites W1993080270 @default.
• W4297260103 cites W1996153970 @default.
• W4297260103 cites W2004293194 @default.
• W4297260103 cites W2009870816 @default.
• W4297260103 cites W2015911399 @default.
• W4297260103 cites W2026717773 @default.
• W4297260103 cites W2039240477 @default.
• W4297260103 cites W2042590605 @default.
• W4297260103 cites W2045262404 @default.
• W4297260103 cites W2055204341 @default.
• W4297260103 cites W2112278807 @default.
• W4297260103 cites W2136444917 @default.
• W4297260103 cites W2138666077 @default.
• W4297260103 cites W2142635246 @default.
• W4297260103 cites W2145625835 @default.
• W4297260103 cites W2158232675 @default.
• W4297260103 cites W2183481716 @default.
• W4297260103 cites W2802395419 @default.
• W4297260103 cites W2805624515 @default.
• W4297260103 cites W2890627020 @default.
• W4297260103 cites W2898738702 @default.
• W4297260103 cites W2910358403 @default.
• W4297260103 cites W2951592748 @default.
• W4297260103 cites W2955521516 @default.
• W4297260103 cites W2975242678 @default.
• W4297260103 cites W2977625058 @default.
• W4297260103 cites W2984962205 @default.
• W4297260103 cites W3092761713 @default.
• W4297260103 cites W4281866074 @default.
• W4297260103 doi "https://doi.org/10.1177/0271678x221126830" @default.
• W4297260103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36163685" @default.
• W4297260103 hasPublicationYear "2022" @default.
• W4297260103 type Work @default.
• W4297260103 citedByCount "0" @default.
• W4297260103 crossrefType "journal-article" @default.
• W4297260103 hasAuthorship W4297260103A5003445744 @default.
• W4297260103 hasAuthorship W4297260103A5019976313 @default.
• W4297260103 hasAuthorship W4297260103A5026942684 @default.
• W4297260103 hasAuthorship W4297260103A5028878666 @default.
• W4297260103 hasAuthorship W4297260103A5037191547 @default.
• W4297260103 hasAuthorship W4297260103A5037765698 @default.
• W4297260103 hasAuthorship W4297260103A5049341241 @default.
• W4297260103 hasAuthorship W4297260103A5051194718 @default.
• W4297260103 hasAuthorship W4297260103A5055059044 @default.
• W4297260103 hasAuthorship W4297260103A5059258714 @default.
• W4297260103 hasAuthorship W4297260103A5061317213 @default.
• W4297260103 hasAuthorship W4297260103A5063074613 @default.
• W4297260103 hasAuthorship W4297260103A5067273656 @default.
• W4297260103 hasAuthorship W4297260103A5069359372 @default.
• W4297260103 hasAuthorship W4297260103A5081327813 @default.
• W4297260103 hasAuthorship W4297260103A5087888043 @default.
• W4297260103 hasBestOaLocation W42972601031 @default.
• W4297260103 hasConcept C12554922 @default.
• W4297260103 hasConcept C126322002 @default.
• W4297260103 hasConcept C150903083 @default.
• W4297260103 hasConcept C169760540 @default.
• W4297260103 hasConcept C170493617 @default.
• W4297260103 hasConcept C185592680 @default.
• W4297260103 hasConcept C202751555 @default.
• W4297260103 hasConcept C207001950 @default.
• W4297260103 hasConcept C26291073 @default.
• W4297260103 hasConcept C2776914184 @default.
• W4297260103 hasConcept C2777670902 @default.
• W4297260103 hasConcept C55493867 @default.
• W4297260103 hasConcept C57306754 @default.
• W4297260103 hasConcept C60592354 @default.
• W4297260103 hasConcept C67847695 @default.
• W4297260103 hasConcept C71924100 @default.
• W4297260103 hasConcept C86803240 @default.
• W4297260103 hasConcept C87753298 @default.
• W4297260103 hasConceptScore W4297260103C12554922 @default.
• W4297260103 hasConceptScore W4297260103C126322002 @default.
• W4297260103 hasConceptScore W4297260103C150903083 @default.
• W4297260103 hasConceptScore W4297260103C169760540 @default.
• W4297260103 hasConceptScore W4297260103C170493617 @default.

• next