Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297260158> ?p ?o ?g. }
- W4297260158 abstract "Cells shape their extracellular milieu by secreting intracellular products into the environment including extracellular vesicles which are lipid-bilayer limited membrane particles. These vesicles carry out a range of functions, including regulation of coagulation, via multiple contributor mechanisms. Urinary extracellular vesicles are secreted by various cells, lining the urinary space, including the nephron and bladder. They are known to have procoagulant properties, however, the details of this function, beyond tissue factor are not well known. The aim of the study was to access the role of urinary extracellular vesicles in impacting coagulation upon supplementation to plasma. This could indicate their physiological function upon kidney injury or pathology. Supplementation to standard human plasma and plasmas deficient in various coagulation factors was used for this purpose, and calibrated automated thrombogram (CAT®) was the major technique applied. We found that these vesicles contain multiple coagulation-related factors, and their lipid composition affects coagulation activities of plasma upon supplementation. Remarkably, these vesicles can restore thrombin generation in FVII, FVIII, FIX and FXI -deficient plasmas. This study explores the multiple roles of urinary extracellular vesicles in coagulation in in vitro blood coagulation and implies their importance in its regulation by several mechanisms." @default.
- W4297260158 created "2022-09-28" @default.
- W4297260158 creator A5000876912 @default.
- W4297260158 creator A5011289968 @default.
- W4297260158 creator A5026055080 @default.
- W4297260158 creator A5032384107 @default.
- W4297260158 creator A5037647301 @default.
- W4297260158 creator A5039962715 @default.
- W4297260158 creator A5045081403 @default.
- W4297260158 creator A5054501795 @default.
- W4297260158 creator A5067942538 @default.
- W4297260158 date "2022-09-07" @default.
- W4297260158 modified "2023-10-06" @default.
- W4297260158 title "Urinary extracellular vesicles carry multiple activators and regulators of coagulation" @default.
- W4297260158 cites W1175330241 @default.
- W4297260158 cites W128231963 @default.
- W4297260158 cites W1893775 @default.
- W4297260158 cites W1972070926 @default.
- W4297260158 cites W1982171456 @default.
- W4297260158 cites W1982991544 @default.
- W4297260158 cites W1986321004 @default.
- W4297260158 cites W1989392175 @default.
- W4297260158 cites W1991525001 @default.
- W4297260158 cites W1993705798 @default.
- W4297260158 cites W1994240225 @default.
- W4297260158 cites W1999174046 @default.
- W4297260158 cites W2032859887 @default.
- W4297260158 cites W2044815926 @default.
- W4297260158 cites W2049518882 @default.
- W4297260158 cites W2055313665 @default.
- W4297260158 cites W2064317487 @default.
- W4297260158 cites W2073330818 @default.
- W4297260158 cites W2083239894 @default.
- W4297260158 cites W2100927341 @default.
- W4297260158 cites W2105628127 @default.
- W4297260158 cites W2117918930 @default.
- W4297260158 cites W2129428834 @default.
- W4297260158 cites W2135486988 @default.
- W4297260158 cites W2141702039 @default.
- W4297260158 cites W2150623910 @default.
- W4297260158 cites W2152936026 @default.
- W4297260158 cites W2253658769 @default.
- W4297260158 cites W2254471596 @default.
- W4297260158 cites W2318362079 @default.
- W4297260158 cites W2398306859 @default.
- W4297260158 cites W2414139056 @default.
- W4297260158 cites W2415651303 @default.
- W4297260158 cites W2417623897 @default.
- W4297260158 cites W2538423274 @default.
- W4297260158 cites W2554645977 @default.
- W4297260158 cites W2557552778 @default.
- W4297260158 cites W2558696224 @default.
- W4297260158 cites W2947941278 @default.
- W4297260158 cites W4206217670 @default.
- W4297260158 doi "https://doi.org/10.3389/fcell.2022.967482" @default.
- W4297260158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36158187" @default.
- W4297260158 hasPublicationYear "2022" @default.
- W4297260158 type Work @default.
- W4297260158 citedByCount "0" @default.
- W4297260158 crossrefType "journal-article" @default.
- W4297260158 hasAuthorship W4297260158A5000876912 @default.
- W4297260158 hasAuthorship W4297260158A5011289968 @default.
- W4297260158 hasAuthorship W4297260158A5026055080 @default.
- W4297260158 hasAuthorship W4297260158A5032384107 @default.
- W4297260158 hasAuthorship W4297260158A5037647301 @default.
- W4297260158 hasAuthorship W4297260158A5039962715 @default.
- W4297260158 hasAuthorship W4297260158A5045081403 @default.
- W4297260158 hasAuthorship W4297260158A5054501795 @default.
- W4297260158 hasAuthorship W4297260158A5067942538 @default.
- W4297260158 hasBestOaLocation W42972601581 @default.
- W4297260158 hasConcept C104317684 @default.
- W4297260158 hasConcept C126322002 @default.
- W4297260158 hasConcept C130316041 @default.
- W4297260158 hasConcept C145059251 @default.
- W4297260158 hasConcept C185592680 @default.
- W4297260158 hasConcept C186738567 @default.
- W4297260158 hasConcept C203014093 @default.
- W4297260158 hasConcept C20518536 @default.
- W4297260158 hasConcept C2778382381 @default.
- W4297260158 hasConcept C28406088 @default.
- W4297260158 hasConcept C2908689518 @default.
- W4297260158 hasConcept C2992929900 @default.
- W4297260158 hasConcept C41625074 @default.
- W4297260158 hasConcept C54173615 @default.
- W4297260158 hasConcept C55493867 @default.
- W4297260158 hasConcept C71924100 @default.
- W4297260158 hasConcept C86803240 @default.
- W4297260158 hasConcept C95444343 @default.
- W4297260158 hasConceptScore W4297260158C104317684 @default.
- W4297260158 hasConceptScore W4297260158C126322002 @default.
- W4297260158 hasConceptScore W4297260158C130316041 @default.
- W4297260158 hasConceptScore W4297260158C145059251 @default.
- W4297260158 hasConceptScore W4297260158C185592680 @default.
- W4297260158 hasConceptScore W4297260158C186738567 @default.
- W4297260158 hasConceptScore W4297260158C203014093 @default.
- W4297260158 hasConceptScore W4297260158C20518536 @default.
- W4297260158 hasConceptScore W4297260158C2778382381 @default.
- W4297260158 hasConceptScore W4297260158C28406088 @default.
- W4297260158 hasConceptScore W4297260158C2908689518 @default.
- W4297260158 hasConceptScore W4297260158C2992929900 @default.