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- W4297261570 endingPage "108443" @default.
- W4297261570 startingPage "108443" @default.
- W4297261570 abstract "Histone H3 Lys4 (H3K4) methylation is catalyzed by the Histone-Lysine N-Methyltransferase 2 (KMT2) protein family, and its members are required for gene expression control. In vertebrates, the KMT2s function in large multisubunit complexes known as COMPASS or COMPASS-like complexes (COMplex of Proteins ASsociated with Set1). The activity of these complexes is critical for proper development, and mutation-induced defects in their functioning have frequently been found in human cancers. Moreover, inherited or de novo mutations in KMT2 genes are among the etiological factors in neurodevelopmental disorders such as Kabuki and Kleefstra syndromes. The canonical role of KMT2s is to catalyze H3K4 methylation, which results in a permissive chromatin environment that drives gene expression. However, current findings described in this review demonstrate that these enzymes can regulate processes that are not dependent on methylation: noncatalytic functions of KMT2s include DNA damage response, cell division, and metabolic activities. Moreover, these enzymes may also methylate non-histone substrates and play a methylation-dependent function in the DNA damage response. In this review, we present an overview of the new, noncanonical activities of KMT2 complexes in a variety of cellular processes. These discoveries may have crucial implications for understanding the functions of these methyltransferases in developmental processes, disease, and epigenome-targeting therapeutic strategies in the future." @default.
- W4297261570 created "2022-09-28" @default.
- W4297261570 creator A5006040821 @default.
- W4297261570 creator A5033026135 @default.
- W4297261570 creator A5041138419 @default.
- W4297261570 date "2022-07-01" @default.
- W4297261570 modified "2023-10-01" @default.
- W4297261570 title "Histone–lysine N-methyltransferase 2 (KMT2) complexes – a new perspective" @default.
- W4297261570 cites W1528147088 @default.
- W4297261570 cites W1575147957 @default.
- W4297261570 cites W1583158213 @default.
- W4297261570 cites W1773532024 @default.
- W4297261570 cites W1792586648 @default.
- W4297261570 cites W1824828567 @default.
- W4297261570 cites W1840855988 @default.
- W4297261570 cites W1848866248 @default.
- W4297261570 cites W1912537483 @default.
- W4297261570 cites W1921500083 @default.
- W4297261570 cites W1948730391 @default.
- W4297261570 cites W1965270682 @default.
- W4297261570 cites W1965343063 @default.
- W4297261570 cites W1969671007 @default.
- W4297261570 cites W1970578083 @default.
- W4297261570 cites W1971015258 @default.
- W4297261570 cites W1972343220 @default.
- W4297261570 cites W1974796017 @default.
- W4297261570 cites W1975554088 @default.
- W4297261570 cites W1981069958 @default.
- W4297261570 cites W1982716235 @default.
- W4297261570 cites W1985171686 @default.
- W4297261570 cites W1985515480 @default.
- W4297261570 cites W1986157458 @default.
- W4297261570 cites W1987086578 @default.
- W4297261570 cites W1989388273 @default.
- W4297261570 cites W1991487490 @default.
- W4297261570 cites W1992048312 @default.
- W4297261570 cites W1992662525 @default.
- W4297261570 cites W1992964343 @default.
- W4297261570 cites W1994441122 @default.
- W4297261570 cites W1996224069 @default.
- W4297261570 cites W1996315419 @default.
- W4297261570 cites W1998871958 @default.
- W4297261570 cites W2000474359 @default.
- W4297261570 cites W2003053220 @default.
- W4297261570 cites W2003391080 @default.
- W4297261570 cites W2005909602 @default.
- W4297261570 cites W2006463715 @default.
- W4297261570 cites W2007684630 @default.
- W4297261570 cites W2009304445 @default.
- W4297261570 cites W2010400539 @default.
- W4297261570 cites W2012079366 @default.
- W4297261570 cites W2012606436 @default.
- W4297261570 cites W2013585481 @default.
- W4297261570 cites W2015477868 @default.
- W4297261570 cites W2016058704 @default.
- W4297261570 cites W2016148607 @default.
- W4297261570 cites W2017694656 @default.
- W4297261570 cites W2021910285 @default.
- W4297261570 cites W2022936129 @default.
- W4297261570 cites W2024584416 @default.
- W4297261570 cites W2027216468 @default.
- W4297261570 cites W2031373255 @default.
- W4297261570 cites W203170764 @default.
- W4297261570 cites W2031824350 @default.
- W4297261570 cites W2037215281 @default.
- W4297261570 cites W2037374227 @default.
- W4297261570 cites W2038235796 @default.
- W4297261570 cites W2039904177 @default.
- W4297261570 cites W2040675004 @default.
- W4297261570 cites W2041594420 @default.
- W4297261570 cites W2042254090 @default.
- W4297261570 cites W2048442759 @default.
- W4297261570 cites W2052744416 @default.
- W4297261570 cites W2053964757 @default.
- W4297261570 cites W2054205113 @default.
- W4297261570 cites W2055548320 @default.
- W4297261570 cites W2058330915 @default.
- W4297261570 cites W2058584815 @default.
- W4297261570 cites W2067606904 @default.
- W4297261570 cites W2071965536 @default.
- W4297261570 cites W2072194885 @default.
- W4297261570 cites W2074917365 @default.
- W4297261570 cites W2075052598 @default.
- W4297261570 cites W2077109220 @default.
- W4297261570 cites W2082592723 @default.
- W4297261570 cites W2085183573 @default.
- W4297261570 cites W2086039500 @default.
- W4297261570 cites W2092912586 @default.
- W4297261570 cites W2093407919 @default.
- W4297261570 cites W2094799740 @default.
- W4297261570 cites W2094808650 @default.
- W4297261570 cites W2096011465 @default.
- W4297261570 cites W2096380982 @default.
- W4297261570 cites W2098952156 @default.
- W4297261570 cites W2100663971 @default.
- W4297261570 cites W2101291429 @default.
- W4297261570 cites W2106134616 @default.
- W4297261570 cites W2108453860 @default.