Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297264900> ?p ?o ?g. }
- W4297264900 endingPage "1680" @default.
- W4297264900 startingPage "1666" @default.
- W4297264900 abstract "Two-component systems are ubiquitous signaling mechanisms in bacteria that enable intracellular changes from extracellular cues. These bacterial regulatory systems couple external stimuli to control genetic expression via an autophosphorylation cascade that transduces membrane signals to intracellular locations, thereby allowing bacteria to rapidly adapt to the changing environmental conditions. Well known to control basic cellular processes, it is evident that two-component systems also exercise control over virulence traits, such as motility, secretion systems, and stress responses that impact the complex cascade of networks that alter virulence traits. In the gastrointestinal system, cues for activation of virulence-related two-component systems include metal ions, host-derived metabolites, and gut conditions. The diversity and origin of these cues suggest that the host can exert control over enteric pathogenicity via regulation in the gastrointestinal system. With the rise in multi-drug resistant pathogens, the potential control of pathogenicity with host cues via two-component systems presents a potential alternative to antimicrobials. Though the signaling mechanism itself is well studied, to date there is no systematic review compiling the host-associated cues of two-component systems and virulence traits. This review highlights the direct link between the host gastrointestinal environment and pathogenicity by focusing on two-component systems that are associated with the genetic expression of virulence traits, and that are activated by host-derived cues. The direct link between the host gastrointestinal environment, metabolites, and pathogenicity established in this review both underscores the importance of host-derived cues on bacterial activity and presents an enticing therapeutic target in the fight against antimicrobial resistant pathogens." @default.
- W4297264900 created "2022-09-28" @default.
- W4297264900 creator A5041290178 @default.
- W4297264900 creator A5074286388 @default.
- W4297264900 creator A5087020653 @default.
- W4297264900 date "2022-09-24" @default.
- W4297264900 modified "2023-10-14" @default.
- W4297264900 title "Two-component systems regulate bacterial virulence in response to the host gastrointestinal environment and metabolic cues" @default.
- W4297264900 cites W1487657646 @default.
- W4297264900 cites W1568314805 @default.
- W4297264900 cites W1873112834 @default.
- W4297264900 cites W188879721 @default.
- W4297264900 cites W1946667821 @default.
- W4297264900 cites W1965201359 @default.
- W4297264900 cites W1965844459 @default.
- W4297264900 cites W1969230553 @default.
- W4297264900 cites W1981044688 @default.
- W4297264900 cites W1982056870 @default.
- W4297264900 cites W1988859590 @default.
- W4297264900 cites W1995650385 @default.
- W4297264900 cites W1996719360 @default.
- W4297264900 cites W1997961331 @default.
- W4297264900 cites W2000936082 @default.
- W4297264900 cites W2002375686 @default.
- W4297264900 cites W2006909053 @default.
- W4297264900 cites W2012046093 @default.
- W4297264900 cites W2022415795 @default.
- W4297264900 cites W2026658658 @default.
- W4297264900 cites W2035294907 @default.
- W4297264900 cites W2038021887 @default.
- W4297264900 cites W2047118056 @default.
- W4297264900 cites W2047436386 @default.
- W4297264900 cites W2049821596 @default.
- W4297264900 cites W2054740358 @default.
- W4297264900 cites W2066911604 @default.
- W4297264900 cites W2067834484 @default.
- W4297264900 cites W2081505040 @default.
- W4297264900 cites W2083598245 @default.
- W4297264900 cites W2092941764 @default.
- W4297264900 cites W2096658890 @default.
- W4297264900 cites W2097578275 @default.
- W4297264900 cites W2099264294 @default.
- W4297264900 cites W2102800490 @default.
- W4297264900 cites W2106438061 @default.
- W4297264900 cites W2108705527 @default.
- W4297264900 cites W2114710486 @default.
- W4297264900 cites W2120317655 @default.
- W4297264900 cites W2123152720 @default.
- W4297264900 cites W2125413553 @default.
- W4297264900 cites W2135190897 @default.
- W4297264900 cites W2139638142 @default.
- W4297264900 cites W2157979510 @default.
- W4297264900 cites W2164367233 @default.
- W4297264900 cites W2167194719 @default.
- W4297264900 cites W2168738417 @default.
- W4297264900 cites W2169887727 @default.
- W4297264900 cites W2171374540 @default.
- W4297264900 cites W2179580359 @default.
- W4297264900 cites W2290920145 @default.
- W4297264900 cites W2419207644 @default.
- W4297264900 cites W2498485322 @default.
- W4297264900 cites W2512569592 @default.
- W4297264900 cites W2573553863 @default.
- W4297264900 cites W2610719260 @default.
- W4297264900 cites W2725622653 @default.
- W4297264900 cites W2764155647 @default.
- W4297264900 cites W2768814185 @default.
- W4297264900 cites W2770562910 @default.
- W4297264900 cites W2790746275 @default.
- W4297264900 cites W2793407886 @default.
- W4297264900 cites W2793726343 @default.
- W4297264900 cites W2808070375 @default.
- W4297264900 cites W2808263118 @default.
- W4297264900 cites W2811416510 @default.
- W4297264900 cites W2851397147 @default.
- W4297264900 cites W2891829946 @default.
- W4297264900 cites W2893248012 @default.
- W4297264900 cites W2905552001 @default.
- W4297264900 cites W2948289264 @default.
- W4297264900 cites W2951236357 @default.
- W4297264900 cites W2992779442 @default.
- W4297264900 cites W2995167752 @default.
- W4297264900 cites W3003814453 @default.
- W4297264900 cites W3004884346 @default.
- W4297264900 cites W3013885638 @default.
- W4297264900 cites W3017324533 @default.
- W4297264900 cites W3024360179 @default.
- W4297264900 cites W3024802608 @default.
- W4297264900 cites W3033687039 @default.
- W4297264900 cites W3036182457 @default.
- W4297264900 cites W3042407920 @default.
- W4297264900 cites W3092133354 @default.
- W4297264900 cites W3105956856 @default.
- W4297264900 cites W3108645272 @default.
- W4297264900 cites W3121980983 @default.
- W4297264900 cites W3135899488 @default.
- W4297264900 cites W3136605687 @default.
- W4297264900 cites W3138299437 @default.