FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297265221> ?p ?o ?g. }

• W4297265221 abstract "Ubiquitin-specific protease 1 (USP1) is a deubiquitinase involved in DNA damage repair by modulating the ubiquitination of major regulators, such as PCNA and FANCD2. Because USP1 is highly expressed in many cancers, dysregulation of USP1 contributes to cancer therapy. However, the role of USP1 and the mechanisms underlying chemotherapy remain unclear. In this study, we found high USP1 expression in tumor tissues and that it correlated with poor prognosis in RCC. Mechanistically, USP1 enhanced survivin stabilization by removing ubiquitin. Pharmacological inhibitors (ML23 and pimozide) and siRNA targeting USP1 induced downregulation of survivin expression. In addition, ML323 upregulated DR5 expression by decreasing miR-216a-5p expression at the post-transcriptional level, and miR-216a-5p mimics suppressed the upregulation of DR5 by ML323. Inhibition of USP1 sensitized cancer cells. Overexpression of survivin or knockdown of DR5 markedly prevented the co-treatment with ML323 and TRAIL-induced apoptosis. These results of in vitro were proved in a mouse xenograft model, in which combined treatment significantly reduced tumor size and induced survivin downregulation and DR5 upregulation. Furthermore, USP1 and survivin protein expression showed a positive correlation, whereas miR-216a-5p and DR5 were inversely correlated in RCC tumor tissues. Taken together, our results suggest two target substrates of USP1 and demonstrate the involvement of survivin and DR5 in USP1-targeted chemotherapy." @default.
• W4297265221 created "2022-09-28" @default.
• W4297265221 creator A5009523901 @default.
• W4297265221 creator A5015727351 @default.
• W4297265221 creator A5023127914 @default.
• W4297265221 creator A5023771868 @default.
• W4297265221 creator A5024663468 @default.
• W4297265221 creator A5030896525 @default.
• W4297265221 creator A5039461201 @default.
• W4297265221 creator A5059995518 @default.
• W4297265221 creator A5070894256 @default.
• W4297265221 date "2022-09-24" @default.
• W4297265221 modified "2023-10-17" @default.
• W4297265221 title "Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5" @default.
• W4297265221 cites W1966400302 @default.
• W4297265221 cites W1967402966 @default.
• W4297265221 cites W1970826261 @default.
• W4297265221 cites W1970920944 @default.
• W4297265221 cites W1975437957 @default.
• W4297265221 cites W2000017794 @default.
• W4297265221 cites W2040838836 @default.
• W4297265221 cites W2060459012 @default.
• W4297265221 cites W2079056345 @default.
• W4297265221 cites W2118225942 @default.
• W4297265221 cites W2123322767 @default.
• W4297265221 cites W2134558237 @default.
• W4297265221 cites W2139364069 @default.
• W4297265221 cites W2142280549 @default.
• W4297265221 cites W2144114582 @default.
• W4297265221 cites W2149812033 @default.
• W4297265221 cites W2205130032 @default.
• W4297265221 cites W2281048538 @default.
• W4297265221 cites W2299883270 @default.
• W4297265221 cites W2548092770 @default.
• W4297265221 cites W2593445153 @default.
• W4297265221 cites W2735050451 @default.
• W4297265221 cites W2740262425 @default.
• W4297265221 cites W2886124451 @default.
• W4297265221 cites W2897017008 @default.
• W4297265221 cites W2899510892 @default.
• W4297265221 cites W2904294837 @default.
• W4297265221 cites W2910730704 @default.
• W4297265221 cites W2921528227 @default.
• W4297265221 cites W2944784952 @default.
• W4297265221 cites W2995533802 @default.
• W4297265221 cites W2997902000 @default.
• W4297265221 cites W3023872997 @default.
• W4297265221 cites W3093531500 @default.
• W4297265221 cites W3113117088 @default.
• W4297265221 cites W4200319753 @default.
• W4297265221 cites W4214719462 @default.
• W4297265221 doi "https://doi.org/10.1038/s41419-022-05271-0" @default.
• W4297265221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36153316" @default.
• W4297265221 hasPublicationYear "2022" @default.
• W4297265221 type Work @default.
• W4297265221 citedByCount "6" @default.
• W4297265221 countsByYear W42972652212023 @default.
• W4297265221 crossrefType "journal-article" @default.
• W4297265221 hasAuthorship W4297265221A5009523901 @default.
• W4297265221 hasAuthorship W4297265221A5015727351 @default.
• W4297265221 hasAuthorship W4297265221A5023127914 @default.
• W4297265221 hasAuthorship W4297265221A5023771868 @default.
• W4297265221 hasAuthorship W4297265221A5024663468 @default.
• W4297265221 hasAuthorship W4297265221A5030896525 @default.
• W4297265221 hasAuthorship W4297265221A5039461201 @default.
• W4297265221 hasAuthorship W4297265221A5059995518 @default.
• W4297265221 hasAuthorship W4297265221A5070894256 @default.
• W4297265221 hasBestOaLocation W42972652211 @default.
• W4297265221 hasConcept C104317684 @default.
• W4297265221 hasConcept C121608353 @default.
• W4297265221 hasConcept C127561419 @default.
• W4297265221 hasConcept C153911025 @default.
• W4297265221 hasConcept C173396325 @default.
• W4297265221 hasConcept C185592680 @default.
• W4297265221 hasConcept C190283241 @default.
• W4297265221 hasConcept C25602115 @default.
• W4297265221 hasConcept C2775975398 @default.
• W4297265221 hasConcept C502942594 @default.
• W4297265221 hasConcept C54355233 @default.
• W4297265221 hasConcept C55493867 @default.
• W4297265221 hasConcept C86803240 @default.
• W4297265221 hasConcept C96232424 @default.
• W4297265221 hasConceptScore W4297265221C104317684 @default.
• W4297265221 hasConceptScore W4297265221C121608353 @default.
• W4297265221 hasConceptScore W4297265221C127561419 @default.
• W4297265221 hasConceptScore W4297265221C153911025 @default.
• W4297265221 hasConceptScore W4297265221C173396325 @default.
• W4297265221 hasConceptScore W4297265221C185592680 @default.
• W4297265221 hasConceptScore W4297265221C190283241 @default.
• W4297265221 hasConceptScore W4297265221C25602115 @default.
• W4297265221 hasConceptScore W4297265221C2775975398 @default.
• W4297265221 hasConceptScore W4297265221C502942594 @default.
• W4297265221 hasConceptScore W4297265221C54355233 @default.
• W4297265221 hasConceptScore W4297265221C55493867 @default.
• W4297265221 hasConceptScore W4297265221C86803240 @default.
• W4297265221 hasConceptScore W4297265221C96232424 @default.
• W4297265221 hasFunder F4320322120 @default.
• W4297265221 hasIssue "9" @default.
• W4297265221 hasLocation W42972652211 @default.
• W4297265221 hasLocation W42972652212 @default.

• next