Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297265428> ?p ?o ?g. }
- W4297265428 abstract "Oncogenic reprogramming of cellular metabolism is a hallmark of many cancers, but our mechanistic understanding of how such dysregulation is linked to tumor behavior remains poor. In this study, we have identified dihydroceramide desaturase (DES1)-which catalyzes the last step in de novo sphingolipid synthesis-as necessary for the acquisition of anchorage-independent survival (AIS), a key cancer enabling biology, and establish DES1 as a downstream effector of HER2-driven glucose uptake and metabolism. We further show that DES1 is sufficient to drive AIS and in vitro tumorigenicity and that increased DES1 levels-found in a third of HER2+ breast cancers-are associated with worse survival outcomes. Taken together, our findings reveal a novel pro-tumor role for DES1 as a transducer of HER2-driven glucose metabolic signals and provide evidence that targeting DES1 is an effective approach for overcoming AIS. Results further suggest that DES1 may have utility as a biomarker of aggressive and metastasis-prone HER2+ breast cancer." @default.
- W4297265428 created "2022-09-28" @default.
- W4297265428 creator A5006616875 @default.
- W4297265428 creator A5009289220 @default.
- W4297265428 creator A5016928652 @default.
- W4297265428 creator A5019601615 @default.
- W4297265428 creator A5020029085 @default.
- W4297265428 creator A5030163803 @default.
- W4297265428 creator A5043932620 @default.
- W4297265428 creator A5071229085 @default.
- W4297265428 creator A5074299056 @default.
- W4297265428 creator A5076394795 @default.
- W4297265428 creator A5078129300 @default.
- W4297265428 creator A5087865872 @default.
- W4297265428 date "2022-09-27" @default.
- W4297265428 modified "2023-10-03" @default.
- W4297265428 title "Dihydroceramide desaturase 1 ( <scp>DES1</scp> ) promotes anchorage‐independent survival downstream of <scp>HER2</scp> ‐driven glucose uptake and metabolism" @default.
- W4297265428 cites W163997156 @default.
- W4297265428 cites W1812553909 @default.
- W4297265428 cites W1908864745 @default.
- W4297265428 cites W1966705891 @default.
- W4297265428 cites W1970543690 @default.
- W4297265428 cites W1971072266 @default.
- W4297265428 cites W1972779095 @default.
- W4297265428 cites W1973260880 @default.
- W4297265428 cites W1974884407 @default.
- W4297265428 cites W1982408819 @default.
- W4297265428 cites W1983821491 @default.
- W4297265428 cites W1990562295 @default.
- W4297265428 cites W1992215701 @default.
- W4297265428 cites W1994683536 @default.
- W4297265428 cites W2000099744 @default.
- W4297265428 cites W2010767979 @default.
- W4297265428 cites W2015736508 @default.
- W4297265428 cites W2017564052 @default.
- W4297265428 cites W2017729786 @default.
- W4297265428 cites W2018743749 @default.
- W4297265428 cites W2020372547 @default.
- W4297265428 cites W2021828703 @default.
- W4297265428 cites W2023595695 @default.
- W4297265428 cites W2024817554 @default.
- W4297265428 cites W2031211461 @default.
- W4297265428 cites W2036009804 @default.
- W4297265428 cites W2036143010 @default.
- W4297265428 cites W2039078304 @default.
- W4297265428 cites W2039403501 @default.
- W4297265428 cites W2044922611 @default.
- W4297265428 cites W2049108649 @default.
- W4297265428 cites W2050892074 @default.
- W4297265428 cites W2052138740 @default.
- W4297265428 cites W2060612001 @default.
- W4297265428 cites W2063570387 @default.
- W4297265428 cites W2068444709 @default.
- W4297265428 cites W2074971941 @default.
- W4297265428 cites W2093805100 @default.
- W4297265428 cites W2099019742 @default.
- W4297265428 cites W2099503517 @default.
- W4297265428 cites W2100628426 @default.
- W4297265428 cites W2115507762 @default.
- W4297265428 cites W2124035362 @default.
- W4297265428 cites W2128236448 @default.
- W4297265428 cites W2129758120 @default.
- W4297265428 cites W2132207276 @default.
- W4297265428 cites W2137022580 @default.
- W4297265428 cites W2137227557 @default.
- W4297265428 cites W2140818088 @default.
- W4297265428 cites W2144508508 @default.
- W4297265428 cites W2146674923 @default.
- W4297265428 cites W2158904485 @default.
- W4297265428 cites W2169193975 @default.
- W4297265428 cites W2171273410 @default.
- W4297265428 cites W2227108499 @default.
- W4297265428 cites W2255975777 @default.
- W4297265428 cites W2406417533 @default.
- W4297265428 cites W2463600666 @default.
- W4297265428 cites W2517194940 @default.
- W4297265428 cites W2518834230 @default.
- W4297265428 cites W2587946754 @default.
- W4297265428 cites W2607721315 @default.
- W4297265428 cites W2737785069 @default.
- W4297265428 cites W2768617092 @default.
- W4297265428 cites W2769383666 @default.
- W4297265428 cites W2791796087 @default.
- W4297265428 cites W2794890034 @default.
- W4297265428 cites W2885875075 @default.
- W4297265428 cites W2892089429 @default.
- W4297265428 cites W2906118074 @default.
- W4297265428 cites W2960921967 @default.
- W4297265428 cites W3005666960 @default.
- W4297265428 cites W3089372933 @default.
- W4297265428 cites W3130107892 @default.
- W4297265428 cites W3138749955 @default.
- W4297265428 cites W3160009538 @default.
- W4297265428 cites W3160481384 @default.
- W4297265428 cites W3169314664 @default.
- W4297265428 doi "https://doi.org/10.1096/fj.202200748r" @default.
- W4297265428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36165222" @default.
- W4297265428 hasPublicationYear "2022" @default.
- W4297265428 type Work @default.
- W4297265428 citedByCount "2" @default.