Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297265871> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W4297265871 endingPage "21" @default.
- W4297265871 startingPage "13" @default.
- W4297265871 abstract "CRISPR/Cas9 is a powerful gene-editing technology. Extensive scientific data exist that the CRISPR/Cas9 system can target small, non-coding, active RNA molecules, including microRNAs (miRNAs). miRNAs have been recognized as key regulators of different cell biological processes, such as the modulation of fibrosis and cardiac hypertrophy, as well as the regulation of cardiomyocytes. Also, it has been demonstrated that miRNAs strongly affect organ evolution, and that the concentration of miRNAs can involve the differentiation, development, and function of different organs. In addition, the current findings clearly indicate that miRNAs can select and control their targets based on their concentrations. CRISPR/Cas9 genome-editing technology is a stronger system for stopping miRNAs than previous methods, including antisense inhibitors. CRISPR/Cas9 tools can be used to eliminate small areas of DNA and determine miRNA in cases where similar groups of miRNAs are in the same strand. Herein, besides other emerging strategies, we critically summarize the recent investigations linking miRNA-targeted therapeutics and CRISPR/Cas9 system to clarify and combine different delivery platforms and cell-fate engineering of miRNAs function and miRNA-based therapeutic intervention in cardiac development, function, and disease. Based on our findings from the literature, it appears that the use of the CRISPR/Cas technology provides new perspectives for understanding the molecular mechanism of cardiovascular disease and can be effective in treating and controlling cardiac development, function, and disease in the future." @default.
- W4297265871 created "2022-09-28" @default.
- W4297265871 creator A5005342588 @default.
- W4297265871 creator A5066441392 @default.
- W4297265871 date "2023-03-01" @default.
- W4297265871 modified "2023-10-17" @default.
- W4297265871 title "CRISPR/Cas9 Tool for MicroRNAs Editing in Cardiac Development, Function, and Disease" @default.
- W4297265871 doi "https://doi.org/10.2174/2211536611666220922092601" @default.
- W4297265871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36154577" @default.
- W4297265871 hasPublicationYear "2023" @default.
- W4297265871 type Work @default.
- W4297265871 citedByCount "0" @default.
- W4297265871 crossrefType "journal-article" @default.
- W4297265871 hasAuthorship W4297265871A5005342588 @default.
- W4297265871 hasAuthorship W4297265871A5066441392 @default.
- W4297265871 hasConcept C104317684 @default.
- W4297265871 hasConcept C132455925 @default.
- W4297265871 hasConcept C14036430 @default.
- W4297265871 hasConcept C144501496 @default.
- W4297265871 hasConcept C145059251 @default.
- W4297265871 hasConcept C54355233 @default.
- W4297265871 hasConcept C60644358 @default.
- W4297265871 hasConcept C70721500 @default.
- W4297265871 hasConcept C86803240 @default.
- W4297265871 hasConcept C98108389 @default.
- W4297265871 hasConceptScore W4297265871C104317684 @default.
- W4297265871 hasConceptScore W4297265871C132455925 @default.
- W4297265871 hasConceptScore W4297265871C14036430 @default.
- W4297265871 hasConceptScore W4297265871C144501496 @default.
- W4297265871 hasConceptScore W4297265871C145059251 @default.
- W4297265871 hasConceptScore W4297265871C54355233 @default.
- W4297265871 hasConceptScore W4297265871C60644358 @default.
- W4297265871 hasConceptScore W4297265871C70721500 @default.
- W4297265871 hasConceptScore W4297265871C86803240 @default.
- W4297265871 hasConceptScore W4297265871C98108389 @default.
- W4297265871 hasIssue "1" @default.
- W4297265871 hasLocation W42972658711 @default.
- W4297265871 hasLocation W42972658712 @default.
- W4297265871 hasOpenAccess W4297265871 @default.
- W4297265871 hasPrimaryLocation W42972658711 @default.
- W4297265871 hasRelatedWork W2516842346 @default.
- W4297265871 hasRelatedWork W2527347512 @default.
- W4297265871 hasRelatedWork W2742734776 @default.
- W4297265871 hasRelatedWork W2770152187 @default.
- W4297265871 hasRelatedWork W2900771990 @default.
- W4297265871 hasRelatedWork W2943124855 @default.
- W4297265871 hasRelatedWork W2953290252 @default.
- W4297265871 hasRelatedWork W3030388918 @default.
- W4297265871 hasRelatedWork W3120857162 @default.
- W4297265871 hasRelatedWork W4281757975 @default.
- W4297265871 hasVolume "12" @default.
- W4297265871 isParatext "false" @default.
- W4297265871 isRetracted "false" @default.
- W4297265871 workType "article" @default.