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- W4297340515 abstract "ABSTRACT To make adaptive decisions, we build an internal model of associative relationships in the environment and use it to predict specific forthcoming outcomes. Detailed stimulus-outcome memories are a core feature of such cognitive maps, yet little is known of the neuronal systems that support their encoding. We used fiber photometry, cell-type and pathway-specific optogenetic manipulation, Pavlovian cue-reward conditioning, and a decision-making test in male and female rats, to reveal that ventral tegmental area dopamine (VTADA) projections to the basolateral amygdala (BLA) drive the encoding of stimulus-outcome memories. Dopamine is released in the BLA during stimulus-outcome pairing and VTA DA →BLA activity is necessary and sufficient to link the identifying features of a reward to a predictive cue, but does not mediate general value or reinforcement. These data reveal a dopaminergic pathway for the learning that supports adaptive decision making and help understand how VTA DA neurons achieve their emerging multifaceted role in learning." @default.
- W4297340515 created "2022-09-28" @default.
- W4297340515 creator A5012887903 @default.
- W4297340515 creator A5030239433 @default.
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- W4297340515 date "2022-09-27" @default.
- W4297340515 modified "2023-10-15" @default.
- W4297340515 title "Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories" @default.
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