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• W4297342020 abstract "Abstract MHC-E restricted CD8 T cells show promise in vaccine settings, but their development and specificity remains poorly understood. Here we focus on a CD8 T cell population reactive to a self-peptide (FL9) bound to mouse MHC-E (Qa-1b) that is presented in response to loss of the MHC I processing enzyme ERAAP, termed QFL T cells. We find that mature QFL thymocytes are predominantly CD8αβ +CD4-, show signs of agonist selection, and give rise to both CD8αα and CD8αβ intraepithelial lymphocytes (IEL), as well as memory phenotype CD8αβ T cells. QFL T cells require the MHC I subunit β-2 microglobulin (β2m), but do not require Qa1 b or classical MHC I for positive selection. However, QFL thymocytes do require Qa1 b for agonist selection and full functionality. Our data highlight the relaxed requirements for positive selection of an MHC-E restricted T cell population and suggest a CD8αβ +CD4-pathway for development of CD8αα IELs." @default.
• W4297342020 created "2022-09-28" @default.
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• W4297342020 date "2022-09-27" @default.
• W4297342020 modified "2023-09-27" @default.
• W4297342020 title "The promiscuous development of an unconventional Qa1^b-restricted T cell population" @default.
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• W4297342020 doi "https://doi.org/10.1101/2022.09.26.509583" @default.
• W4297342020 hasPublicationYear "2022" @default.
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