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• W4297342023 abstract "Continuous manufacturing has become a realistic option in the pharmaceutical industry. As such, process design becomes more complicated where this new option is actively investigated. This paper discusses the continuous manufacturing of solid drug products from the process systems engineering perspectives. After summarizing the merits and the challenges of continuous manufacturing, we introduce several research examples in the authors’ research group. Firstly, economic performance and product quality were compared with conventional batch manufacturing. Experimental studies were then performed to obtain practical knowledge of continuous manufacturing. Lastly, a comprehensive process design framework was proposed, using superstructure and activity modeling approaches. In conclusion, appropriate cooperation between simulations and experiments plays a key role in decision-making, including selection between batch and continuous manufacturing." @default.
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• W4297342023 date "2022-08-10" @default.
• W4297342023 modified "2023-10-02" @default.
• W4297342023 title "Continuous Manufacturing of Solid Drug Products — from Process Systems Engineering Perspectives" @default.
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• W4297342023 doi "https://doi.org/10.4164/sptj.59.388" @default.
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