FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297348575> ?p ?o ?g. }

• W4297348575 endingPage "2325" @default.
• W4297348575 startingPage "2325" @default.
• W4297348575 abstract "(1) This study aimed to investigate whether baseline clinical and Positron Emission Tomography/Computed Tomography (bPET)-derived parameters could help predicting early response to the first two cycles of chemotherapy (Deauville Score at interim PET, DS at iPET) in patients with classical Hodgkin lymphoma (cHL) to identify poor responders (DS ≥ 4) who could benefit from first-line treatment intensification at an earlier time point. (2) cHL patients with a bPET and an iPET imaging study in our Centre’s records (2013−2019), no synchronous/metachronous tumors, no major surgical resection of disease prior to bPET, and treated with two cycles of ABVD chemotherapy before iPET were retrospectively included. Baseline International Prognostic Score for HL (IPS) parameters were collected. Each patient’s bPET total metabolic tumor volume (TMTV) and highest tumoral SUVmax were collected. ROC curves and Youden’s index were used to derive the optimal thresholds of TMTV and SUVmax with regard to the DS (≥4). Chi-square or Fisher’s exact test were used for the univariate analysis. A multivariate analysis was then performed using logistic regression. The type I error rate in the hypothesis testing was set to 5%. (3) A total of 146 patients were included. The optimal threshold to predict a DS ≥ 4 was >177 mL for TMTV and >14.7 for SUVmax (AUC of 0.65 and 0.58, respectively). The univariate analysis showed that only TMTV, SUVmax, advanced disease stage, and age were significantly associated with a DS ≥ 4. A multivariate model was finally derived from TMTV, SUVmax, and age, with an AUC of 0.77. (4) A multivariate model with bPET parameters and age at diagnosis was satisfactorily predictive of poor response at iPET after ABVD induction chemotherapy in cHL patients. More studies are needed to validate these results and further implement DS-predictive factors at baseline in order to prevent poor response and intensify therapeutic strategies a-priori when needed." @default.
• W4297348575 created "2022-09-28" @default.
• W4297348575 creator A5000611970 @default.
• W4297348575 creator A5005359407 @default.
• W4297348575 creator A5005592897 @default.
• W4297348575 creator A5027924771 @default.
• W4297348575 creator A5035043785 @default.
• W4297348575 creator A5048766102 @default.
• W4297348575 date "2022-09-26" @default.
• W4297348575 modified "2023-09-30" @default.
• W4297348575 title "Classical Hodgkin Lymphoma: A Joint Clinical and PET Model to Predict Poor Responders at Interim Assessment" @default.
• W4297348575 cites W2051650384 @default.
• W4297348575 cites W2063563316 @default.
• W4297348575 cites W2084446054 @default.
• W4297348575 cites W2088783247 @default.
• W4297348575 cites W2119147717 @default.
• W4297348575 cites W2131900456 @default.
• W4297348575 cites W2328676772 @default.
• W4297348575 cites W2537218914 @default.
• W4297348575 cites W2598700764 @default.
• W4297348575 cites W2615482883 @default.
• W4297348575 cites W2624324938 @default.
• W4297348575 cites W2802883686 @default.
• W4297348575 cites W2883152284 @default.
• W4297348575 cites W2918956129 @default.
• W4297348575 cites W2996615575 @default.
• W4297348575 cites W2998434467 @default.
• W4297348575 cites W3017958662 @default.
• W4297348575 cites W3043979833 @default.
• W4297348575 cites W3044532926 @default.
• W4297348575 cites W3131237683 @default.
• W4297348575 cites W3181046270 @default.
• W4297348575 cites W3191554766 @default.
• W4297348575 cites W3196243885 @default.
• W4297348575 cites W3204853003 @default.
• W4297348575 cites W4206048061 @default.
• W4297348575 cites W4220781696 @default.
• W4297348575 doi "https://doi.org/10.3390/diagnostics12102325" @default.
• W4297348575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36292014" @default.
• W4297348575 hasPublicationYear "2022" @default.
• W4297348575 type Work @default.
• W4297348575 citedByCount "1" @default.
• W4297348575 countsByYear W42973485752023 @default.
• W4297348575 crossrefType "journal-article" @default.
• W4297348575 hasAuthorship W4297348575A5000611970 @default.
• W4297348575 hasAuthorship W4297348575A5005359407 @default.
• W4297348575 hasAuthorship W4297348575A5005592897 @default.
• W4297348575 hasAuthorship W4297348575A5027924771 @default.
• W4297348575 hasAuthorship W4297348575A5035043785 @default.
• W4297348575 hasAuthorship W4297348575A5048766102 @default.
• W4297348575 hasBestOaLocation W42973485751 @default.
• W4297348575 hasConcept C105795698 @default.
• W4297348575 hasConcept C126322002 @default.
• W4297348575 hasConcept C143998085 @default.
• W4297348575 hasConcept C144301174 @default.
• W4297348575 hasConcept C146357865 @default.
• W4297348575 hasConcept C151730666 @default.
• W4297348575 hasConcept C151956035 @default.
• W4297348575 hasConcept C161584116 @default.
• W4297348575 hasConcept C199163554 @default.
• W4297348575 hasConcept C2775842073 @default.
• W4297348575 hasConcept C2776305933 @default.
• W4297348575 hasConcept C2776694085 @default.
• W4297348575 hasConcept C2776755627 @default.
• W4297348575 hasConcept C2779429289 @default.
• W4297348575 hasConcept C2989005 @default.
• W4297348575 hasConcept C33923547 @default.
• W4297348575 hasConcept C38180746 @default.
• W4297348575 hasConcept C43346845 @default.
• W4297348575 hasConcept C58471807 @default.
• W4297348575 hasConcept C71924100 @default.
• W4297348575 hasConcept C86803240 @default.
• W4297348575 hasConceptScore W4297348575C105795698 @default.
• W4297348575 hasConceptScore W4297348575C126322002 @default.
• W4297348575 hasConceptScore W4297348575C143998085 @default.
• W4297348575 hasConceptScore W4297348575C144301174 @default.
• W4297348575 hasConceptScore W4297348575C146357865 @default.
• W4297348575 hasConceptScore W4297348575C151730666 @default.
• W4297348575 hasConceptScore W4297348575C151956035 @default.
• W4297348575 hasConceptScore W4297348575C161584116 @default.
• W4297348575 hasConceptScore W4297348575C199163554 @default.
• W4297348575 hasConceptScore W4297348575C2775842073 @default.
• W4297348575 hasConceptScore W4297348575C2776305933 @default.
• W4297348575 hasConceptScore W4297348575C2776694085 @default.
• W4297348575 hasConceptScore W4297348575C2776755627 @default.
• W4297348575 hasConceptScore W4297348575C2779429289 @default.
• W4297348575 hasConceptScore W4297348575C2989005 @default.
• W4297348575 hasConceptScore W4297348575C33923547 @default.
• W4297348575 hasConceptScore W4297348575C38180746 @default.
• W4297348575 hasConceptScore W4297348575C43346845 @default.
• W4297348575 hasConceptScore W4297348575C58471807 @default.
• W4297348575 hasConceptScore W4297348575C71924100 @default.
• W4297348575 hasConceptScore W4297348575C86803240 @default.
• W4297348575 hasIssue "10" @default.
• W4297348575 hasLocation W42973485751 @default.
• W4297348575 hasLocation W42973485752 @default.
• W4297348575 hasLocation W42973485753 @default.
• W4297348575 hasLocation W42973485754 @default.

• next