Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297361119> ?p ?o ?g. }
- W4297361119 endingPage "100064" @default.
- W4297361119 startingPage "100064" @default.
- W4297361119 abstract "Physiological inflammation has been shown to promote bone regeneration; however, prolonged inflammation impedes the osteogenesis and bone repair process. To overcome the latter we aimed to develop a dual drug delivering nanofibrous scaffold to promote osteogenic differentiation of mesenchymal stromal cells (MSCs) and modulate the pro-inflammatory response of macrophages. The polycaprolactone (PCL)-collagen nanofibrous delivery system incorporating dexamethasone and simvastatin was fabricated by electrospinning process. The morphological analysis and mRNA, as well as protein expression of proinflammatory and anti-inflammatory cytokines in human monocytes (U937 cells), demonstrated the immunocompatibility effect of dual drug-releasing nanofibrous scaffolds. Nitric oxide estimation also demonstrated the anti-inflammatory effect of dual drug releasing scaffolds. The scaffolds demonstrated the osteogenic differentiation of adipose-derived MSCs by enhancing the alkaline phosphatase (ALP) activity and mineral deposition after 17 days of cell culture. The increased expression of Runt-related transcription factor-2 (RUNX-2) and osteocalcin at mRNA and protein levels supported the osteogenic potential of dual drug-loaded fibrous scaffolds. Hence, the results indicate that our fabricated nanofibrous scaffolds exhibit immunomodulatory properties and could be employed for bone regeneration applications after further in-vivo validation." @default.
- W4297361119 created "2022-09-28" @default.
- W4297361119 creator A5000780114 @default.
- W4297361119 creator A5004088853 @default.
- W4297361119 creator A5020704309 @default.
- W4297361119 creator A5045201975 @default.
- W4297361119 creator A5083078553 @default.
- W4297361119 date "2022-12-01" @default.
- W4297361119 modified "2023-10-01" @default.
- W4297361119 title "Polycaprolactone-collagen nanofibers loaded with dexamethasone and simvastatin as an osteoinductive and immunocompatible scaffold for bone regeneration applications" @default.
- W4297361119 cites W1846286668 @default.
- W4297361119 cites W1953179980 @default.
- W4297361119 cites W1967951605 @default.
- W4297361119 cites W1977959012 @default.
- W4297361119 cites W2002192590 @default.
- W4297361119 cites W2002602405 @default.
- W4297361119 cites W2019225336 @default.
- W4297361119 cites W2032853317 @default.
- W4297361119 cites W2042278836 @default.
- W4297361119 cites W2052969825 @default.
- W4297361119 cites W2066646366 @default.
- W4297361119 cites W2072739496 @default.
- W4297361119 cites W2081896745 @default.
- W4297361119 cites W2086530747 @default.
- W4297361119 cites W2087353148 @default.
- W4297361119 cites W2132935720 @default.
- W4297361119 cites W2140380746 @default.
- W4297361119 cites W2277745662 @default.
- W4297361119 cites W2335363879 @default.
- W4297361119 cites W2395619974 @default.
- W4297361119 cites W2468938755 @default.
- W4297361119 cites W2491549472 @default.
- W4297361119 cites W2518963324 @default.
- W4297361119 cites W2546587401 @default.
- W4297361119 cites W2578851460 @default.
- W4297361119 cites W2606775210 @default.
- W4297361119 cites W2727312753 @default.
- W4297361119 cites W2755257305 @default.
- W4297361119 cites W2764103451 @default.
- W4297361119 cites W2782804285 @default.
- W4297361119 cites W2898917077 @default.
- W4297361119 cites W2912264155 @default.
- W4297361119 cites W2913701849 @default.
- W4297361119 cites W2914156600 @default.
- W4297361119 cites W2923078799 @default.
- W4297361119 cites W2977293821 @default.
- W4297361119 cites W2982895754 @default.
- W4297361119 cites W3003780370 @default.
- W4297361119 cites W3014848260 @default.
- W4297361119 cites W3028459802 @default.
- W4297361119 cites W3097568860 @default.
- W4297361119 cites W3113909000 @default.
- W4297361119 cites W3168981793 @default.
- W4297361119 doi "https://doi.org/10.1016/j.bbiosy.2022.100064" @default.
- W4297361119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36824372" @default.
- W4297361119 hasPublicationYear "2022" @default.
- W4297361119 type Work @default.
- W4297361119 citedByCount "1" @default.
- W4297361119 countsByYear W42973611192023 @default.
- W4297361119 crossrefType "journal-article" @default.
- W4297361119 hasAuthorship W4297361119A5000780114 @default.
- W4297361119 hasAuthorship W4297361119A5004088853 @default.
- W4297361119 hasAuthorship W4297361119A5020704309 @default.
- W4297361119 hasAuthorship W4297361119A5045201975 @default.
- W4297361119 hasAuthorship W4297361119A5083078553 @default.
- W4297361119 hasBestOaLocation W42973611191 @default.
- W4297361119 hasConcept C131075544 @default.
- W4297361119 hasConcept C136229726 @default.
- W4297361119 hasConcept C160160445 @default.
- W4297361119 hasConcept C164027704 @default.
- W4297361119 hasConcept C16930146 @default.
- W4297361119 hasConcept C171056886 @default.
- W4297361119 hasConcept C171250308 @default.
- W4297361119 hasConcept C178790620 @default.
- W4297361119 hasConcept C181199279 @default.
- W4297361119 hasConcept C185592680 @default.
- W4297361119 hasConcept C192562407 @default.
- W4297361119 hasConcept C198826908 @default.
- W4297361119 hasConcept C203014093 @default.
- W4297361119 hasConcept C2776329913 @default.
- W4297361119 hasConcept C2776914184 @default.
- W4297361119 hasConcept C2779868350 @default.
- W4297361119 hasConcept C502942594 @default.
- W4297361119 hasConcept C521977710 @default.
- W4297361119 hasConcept C55493867 @default.
- W4297361119 hasConcept C71924100 @default.
- W4297361119 hasConcept C86803240 @default.
- W4297361119 hasConcept C89429830 @default.
- W4297361119 hasConcept C91129048 @default.
- W4297361119 hasConcept C95444343 @default.
- W4297361119 hasConcept C98274493 @default.
- W4297361119 hasConceptScore W4297361119C131075544 @default.
- W4297361119 hasConceptScore W4297361119C136229726 @default.
- W4297361119 hasConceptScore W4297361119C160160445 @default.
- W4297361119 hasConceptScore W4297361119C164027704 @default.
- W4297361119 hasConceptScore W4297361119C16930146 @default.
- W4297361119 hasConceptScore W4297361119C171056886 @default.
- W4297361119 hasConceptScore W4297361119C171250308 @default.