Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297369287> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4297369287 abstract "The Zika virus has been found in individual cases but has not been confirmed as the cause of in the large number of cases of microcephaly in Brazil in 2015-6. Indeed, disparities between the incidence of Zika and microcephaly across geographic locations has led to questions about the virus's role. Here we consider whether the insecticide pyriproxyfen used in Brazilian drinking water might be the primary cause or a cofactor. Pyriproxifen is a juvenile hormone analog which has been shown to correspond in mammals to a number of fat soluble regulatory molecules including retinoic acid, a metabolite of vitamin A, with which it has cross-reactivity and whose application during development has been shown to cause microcephaly. Methoprene, another juvenile hormone analog approved as an insecticide in the 1970s has been shown to cause developmental disorders in mammals. Isotretinoin is another retinoid causing microcephaly via activation of the retinoid X receptor in developing fetuses. We review tests of pyriproxyfen by the manufacturer Sumitomo, which actually found some evidence for this effect, including low brain mass and arhinencephaly in exposed rat pups. Pyriproxyfen use in Brazil is unprecedented, never having been applied to a water supply on a large scale. Claims that its geographical pattern of use rule it out as a cause have not been documented or confirmed. On the other hand, the very few microcephaly cases reported in Colombia and the wide discrepancies of incidence in different states across Brazil despite large numbers of Zika cases undermine the claim that Zika is the cause. Given this combination of potential molecular mechanism, toxicological and epidemiological evidence we strongly recommend that the use of pyriproxyfen in Brazil be suspended until the potential causal link to microcephaly is investigated further." @default.
- W4297369287 created "2022-09-28" @default.
- W4297369287 creator A5021298223 @default.
- W4297369287 creator A5034827139 @default.
- W4297369287 creator A5037101148 @default.
- W4297369287 creator A5050293424 @default.
- W4297369287 creator A5079381603 @default.
- W4297369287 date "2017-03-07" @default.
- W4297369287 modified "2023-09-23" @default.
- W4297369287 title "The Case for Pyriproxyfen as a Potential Cause for Microcephaly; From Biology to Epidemiology" @default.
- W4297369287 doi "https://doi.org/10.48550/arxiv.1703.03765" @default.
- W4297369287 hasPublicationYear "2017" @default.
- W4297369287 type Work @default.
- W4297369287 citedByCount "0" @default.
- W4297369287 crossrefType "posted-content" @default.
- W4297369287 hasAuthorship W4297369287A5021298223 @default.
- W4297369287 hasAuthorship W4297369287A5034827139 @default.
- W4297369287 hasAuthorship W4297369287A5037101148 @default.
- W4297369287 hasAuthorship W4297369287A5050293424 @default.
- W4297369287 hasAuthorship W4297369287A5079381603 @default.
- W4297369287 hasBestOaLocation W42973692871 @default.
- W4297369287 hasConcept C120665830 @default.
- W4297369287 hasConcept C121332964 @default.
- W4297369287 hasConcept C134018914 @default.
- W4297369287 hasConcept C173758957 @default.
- W4297369287 hasConcept C18903297 @default.
- W4297369287 hasConcept C2522874641 @default.
- W4297369287 hasConcept C2776395126 @default.
- W4297369287 hasConcept C2777053367 @default.
- W4297369287 hasConcept C2777564371 @default.
- W4297369287 hasConcept C2780348099 @default.
- W4297369287 hasConcept C54355233 @default.
- W4297369287 hasConcept C61511704 @default.
- W4297369287 hasConcept C71220013 @default.
- W4297369287 hasConcept C71315377 @default.
- W4297369287 hasConcept C86803240 @default.
- W4297369287 hasConceptScore W4297369287C120665830 @default.
- W4297369287 hasConceptScore W4297369287C121332964 @default.
- W4297369287 hasConceptScore W4297369287C134018914 @default.
- W4297369287 hasConceptScore W4297369287C173758957 @default.
- W4297369287 hasConceptScore W4297369287C18903297 @default.
- W4297369287 hasConceptScore W4297369287C2522874641 @default.
- W4297369287 hasConceptScore W4297369287C2776395126 @default.
- W4297369287 hasConceptScore W4297369287C2777053367 @default.
- W4297369287 hasConceptScore W4297369287C2777564371 @default.
- W4297369287 hasConceptScore W4297369287C2780348099 @default.
- W4297369287 hasConceptScore W4297369287C54355233 @default.
- W4297369287 hasConceptScore W4297369287C61511704 @default.
- W4297369287 hasConceptScore W4297369287C71220013 @default.
- W4297369287 hasConceptScore W4297369287C71315377 @default.
- W4297369287 hasConceptScore W4297369287C86803240 @default.
- W4297369287 hasLocation W42973692871 @default.
- W4297369287 hasLocation W42973692872 @default.
- W4297369287 hasOpenAccess W4297369287 @default.
- W4297369287 hasPrimaryLocation W42973692871 @default.
- W4297369287 hasRelatedWork W2034526088 @default.
- W4297369287 hasRelatedWork W2340409514 @default.
- W4297369287 hasRelatedWork W2469424112 @default.
- W4297369287 hasRelatedWork W2595031697 @default.
- W4297369287 hasRelatedWork W2949538517 @default.
- W4297369287 hasRelatedWork W2953239226 @default.
- W4297369287 hasRelatedWork W3031581507 @default.
- W4297369287 hasRelatedWork W3049204918 @default.
- W4297369287 hasRelatedWork W4300505601 @default.
- W4297369287 hasRelatedWork W4300871767 @default.
- W4297369287 isParatext "false" @default.
- W4297369287 isRetracted "false" @default.
- W4297369287 workType "article" @default.