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• W4297369898 abstract "Background Alcohol use disorders (AUDs) leading to liver disease is major concern over other spectrum of disorder. Excessive alcohol consumption resulting in leaky gut syndrome is attributed to alcohol-induced liver injury through portal translocation of bacterial endotoxin. Susceptibility to alcoholic liver disease (ALD) in AUD patients could be dependent upon genes responsible for inflammation and alcohol metabolism. The pattern recognition receptor CD14 gene is a major player in endotoxin-mediated inflammation and susceptibility to ALD. This study investigated the genetic association of CD14 polymorphisms and other mechanisms relevant to altered inflammatory responses leading to ALD. Methods Patients with alcohol use disorder with ALD (n = 128) and without liver disease (ALC, n = 184) and controls without alcohol use disorder (NALC, n = 152) from North India were enrolled. The CD4 gene polymorphisms in the North Indian population were evaluated by RFLP and sequencing. Secretory CD14 (sCD14), LBP, TLR4, MD2, TNFα, IL1b, IFNγ, IL6, IL10, and IL4 levels in serum were measured by ELISA among groups. The influence of polymorphisms on CD14 gene promoter activity and circulatory bacterial DNA level was determined. Results The CD14 gene promoter and exonic region SNPs were found to be monomorphic, except for SNP rs2569190 for the North Indian population. The genetic association of SNP rs2569190(C/T) with the risk of developing ALD was found significant for TT genotype [OR TT , 95% CI = 2.19, 1.16–4.13 for ALD vs. ALC and OR, 2.09, 1.18–3.72 for ALD vs. NALC]. An increased sCD14 level was observed in AUD patients compared to NALC control. Increased levels of LBP, TLR4, TNFα, IL1β, IFNγ, and IL6 and reduced levels of MD2, IL10, and IL4 were observed among the ALD patients compared to the other two control groups. Elevated levels of pro-inflammatory and reduced levels of anti-inflammatory cytokines were observed in the risk genotype TT groups of ALD patients and the ALC group compared to NALC. Promoter activity was observed in the intronic region flanking SNPs and risk genotype can influence reporter activity, indicating CD14 gene expression. Conclusion Enhanced CD14 expression associated with inflammatory responses increases susceptibility to ALD in the TT genotype of AUD patients." @default.
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• W4297369898 date "2022-09-27" @default.
• W4297369898 modified "2023-10-02" @default.
• W4297369898 title "Pattern recognition receptor CD14 gene polymorphisms in alcohol use disorder patients and its Influence on liver disease susceptibility" @default.
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• W4297369898 cites W1504603444 @default.
• W4297369898 cites W1540456190 @default.
• W4297369898 cites W1582455747 @default.
• W4297369898 cites W185724496 @default.
• W4297369898 cites W1874222778 @default.
• W4297369898 cites W1975786557 @default.
• W4297369898 cites W1976737945 @default.
• W4297369898 cites W1977213133 @default.
• W4297369898 cites W1978337792 @default.
• W4297369898 cites W1982345842 @default.
• W4297369898 cites W1987793574 @default.
• W4297369898 cites W1990153938 @default.
• W4297369898 cites W1993738044 @default.
• W4297369898 cites W1999426232 @default.
• W4297369898 cites W2012295343 @default.
• W4297369898 cites W2016849191 @default.
• W4297369898 cites W2019295440 @default.
• W4297369898 cites W2019937507 @default.
• W4297369898 cites W2021192988 @default.
• W4297369898 cites W2028810695 @default.
• W4297369898 cites W2032479841 @default.
• W4297369898 cites W2035086157 @default.
• W4297369898 cites W2036103787 @default.
• W4297369898 cites W2036932408 @default.
• W4297369898 cites W2038697192 @default.
• W4297369898 cites W2045787858 @default.
• W4297369898 cites W2055452745 @default.
• W4297369898 cites W2062498772 @default.
• W4297369898 cites W2066703560 @default.
• W4297369898 cites W2067394045 @default.
• W4297369898 cites W2074673544 @default.
• W4297369898 cites W2087867048 @default.
• W4297369898 cites W2088834687 @default.
• W4297369898 cites W2089097077 @default.
• W4297369898 cites W2096166085 @default.
• W4297369898 cites W2101199845 @default.
• W4297369898 cites W2103125300 @default.
• W4297369898 cites W2103741698 @default.
• W4297369898 cites W2111782917 @default.
• W4297369898 cites W2127934565 @default.
• W4297369898 cites W2128548864 @default.
• W4297369898 cites W2136330017 @default.
• W4297369898 cites W2139825247 @default.
• W4297369898 cites W2148528998 @default.
• W4297369898 cites W2149915109 @default.
• W4297369898 cites W2151608099 @default.
• W4297369898 cites W2151956996 @default.
• W4297369898 cites W2162664755 @default.
• W4297369898 cites W2170785661 @default.
• W4297369898 cites W2176189882 @default.
• W4297369898 cites W2253819322 @default.
• W4297369898 cites W2331943050 @default.
• W4297369898 cites W2396158073 @default.
• W4297369898 cites W2551497671 @default.
• W4297369898 cites W2597816263 @default.
• W4297369898 cites W2749553700 @default.
• W4297369898 cites W2766266133 @default.
• W4297369898 cites W2782155444 @default.
• W4297369898 cites W2910641447 @default.
• W4297369898 cites W2917931584 @default.
• W4297369898 cites W3092849554 @default.
• W4297369898 cites W3092861045 @default.
• W4297369898 cites W3098081708 @default.
• W4297369898 cites W3108323500 @default.
• W4297369898 cites W4244290649 @default.
• W4297369898 doi "https://doi.org/10.3389/fimmu.2022.975027" @default.
• W4297369898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36238273" @default.
• W4297369898 hasPublicationYear "2022" @default.
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