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- W4297374014 endingPage "111410" @default.
- W4297374014 startingPage "111410" @default.
- W4297374014 abstract "Microbial communities execute metabolic pathways to drive global nutrient cycles. Within a community, functionally specialized strains can perform different yet complementary steps within a linear pathway, a phenomenon termed metabolic division of labor (MDOL). However, little is known about how such metabolic behaviors shape microbial communities. Here, we derive a theoretical framework to define the assembly of a community that degrades an organic compound through MDOL. The framework indicates that to ensure community stability, the strains performing the initial steps should hold a growth advantage (m) over the private benefit (n) of the strain performing the last step. The steady-state frequency of the last strain is then determined by the quotient of n and m. Our experiments show that the framework accurately predicts the assembly of our synthetic consortia that degrade naphthalene through MDOL. Our results provide insights for designing and managing stable microbial systems for metabolic pathway optimization." @default.
- W4297374014 created "2022-09-28" @default.
- W4297374014 creator A5006917061 @default.
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- W4297374014 date "2022-09-01" @default.
- W4297374014 modified "2023-10-13" @default.
- W4297374014 title "Even allocation of benefits stabilizes microbial community engaged in metabolic division of labor" @default.
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