FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297389715> ?p ?o ?g. }

• W4297389715 endingPage "847.e8" @default.
• W4297389715 startingPage "847.e1" @default.
• W4297389715 abstract "Although autologous hematopoietic cell transplantation (HCT) is an established therapy for patients with relapsed acute promyelocytic leukemia (APL) after returning to complete remission (CR), the role of allogeneic HCT remains unclear for treating relapsed APL. This study aimed to investigate allogeneic HCT outcomes in patients with relapsed APL, focusing particularly on those who underwent transplantation in non-CR and those who had relapsed after prior autologous HCT. We retrospectively analyzed Japanese nationwide transplantation registry data of patients with relapsed APL age ≥16 years who underwent allogeneic HCT between 2006 and 2020. A total of 195 patients were eligible for this analysis, including 69 who underwent transplantation in non-CR and 55 who relapsed after prior autologous HCT. The median duration of follow-up for survivors was 5.4 years. Multivariate analysis revealed that both non-CR at transplantation (hazard ratio [HR], 1.74; 95% confidence interval [CI], 1.12 to 2.71; P = .014) and prior autologous HCT (HR, 2.10; 95% CI, 1.28 to 3.44; P = .013) were associated with higher risks of overall mortality. The 5-year overall survival (OS) rates for patients who underwent transplantation in CR and non-CR were 58% and 39%, respectively (P = .085), if they did not have a history of prior autologous HCT. In the patients who had relapsed after prior autologous HCT, the 5-year OS rate was 47% for those who underwent allogeneic HCT in CR and 6% for those who did so in non-CR (P = .001). Allogeneic HCT still provides an opportunity for long-term survival for certain patients with relapsed APL for whom autologous HCT is unlikely to be effective. The dismal outcome of those with prior autologous HCT who underwent allogeneic HCT in non-CR poses a significant therapeutic challenge." @default.
• W4297389715 created "2022-09-28" @default.
• W4297389715 creator A5001196940 @default.
• W4297389715 creator A5005166350 @default.
• W4297389715 creator A5007951151 @default.
• W4297389715 creator A5011163782 @default.
• W4297389715 creator A5015601730 @default.
• W4297389715 creator A5020985742 @default.
• W4297389715 creator A5023529619 @default.
• W4297389715 creator A5024134742 @default.
• W4297389715 creator A5033486602 @default.
• W4297389715 creator A5037325986 @default.
• W4297389715 creator A5046989635 @default.
• W4297389715 creator A5047575606 @default.
• W4297389715 creator A5049556471 @default.
• W4297389715 creator A5049803192 @default.
• W4297389715 creator A5057323751 @default.
• W4297389715 creator A5067604014 @default.
• W4297389715 creator A5077166961 @default.
• W4297389715 creator A5082245729 @default.
• W4297389715 date "2022-12-01" @default.
• W4297389715 modified "2023-09-24" @default.
• W4297389715 title "Allogeneic Hematopoietic Cell Transplantation for Patients with Relapsed Acute Promyelocytic Leukemia" @default.
• W4297389715 cites W1931891535 @default.
• W4297389715 cites W1948328750 @default.
• W4297389715 cites W1992276338 @default.
• W4297389715 cites W1996652585 @default.
• W4297389715 cites W2005604237 @default.
• W4297389715 cites W2019187521 @default.
• W4297389715 cites W2020786155 @default.
• W4297389715 cites W2045926255 @default.
• W4297389715 cites W2060038105 @default.
• W4297389715 cites W2066710634 @default.
• W4297389715 cites W2071930065 @default.
• W4297389715 cites W2076668534 @default.
• W4297389715 cites W2081818298 @default.
• W4297389715 cites W2128291738 @default.
• W4297389715 cites W2128812336 @default.
• W4297389715 cites W2129338773 @default.
• W4297389715 cites W2142467765 @default.
• W4297389715 cites W2153610769 @default.
• W4297389715 cites W2166406669 @default.
• W4297389715 cites W2337302783 @default.
• W4297389715 cites W2529417758 @default.
• W4297389715 cites W2559537906 @default.
• W4297389715 cites W2561289538 @default.
• W4297389715 cites W2726522927 @default.
• W4297389715 cites W2740686538 @default.
• W4297389715 cites W2810726249 @default.
• W4297389715 cites W2887149281 @default.
• W4297389715 cites W2918095490 @default.
• W4297389715 cites W2981222254 @default.
• W4297389715 cites W3006103213 @default.
• W4297389715 cites W3102220928 @default.
• W4297389715 cites W3113084685 @default.
• W4297389715 cites W3135869910 @default.
• W4297389715 cites W3207605146 @default.
• W4297389715 doi "https://doi.org/10.1016/j.jtct.2022.09.021" @default.
• W4297389715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36179987" @default.
• W4297389715 hasPublicationYear "2022" @default.
• W4297389715 type Work @default.
• W4297389715 citedByCount "2" @default.
• W4297389715 countsByYear W42973897152023 @default.
• W4297389715 crossrefType "journal-article" @default.
• W4297389715 hasAuthorship W4297389715A5001196940 @default.
• W4297389715 hasAuthorship W4297389715A5005166350 @default.
• W4297389715 hasAuthorship W4297389715A5007951151 @default.
• W4297389715 hasAuthorship W4297389715A5011163782 @default.
• W4297389715 hasAuthorship W4297389715A5015601730 @default.
• W4297389715 hasAuthorship W4297389715A5020985742 @default.
• W4297389715 hasAuthorship W4297389715A5023529619 @default.
• W4297389715 hasAuthorship W4297389715A5024134742 @default.
• W4297389715 hasAuthorship W4297389715A5033486602 @default.
• W4297389715 hasAuthorship W4297389715A5037325986 @default.
• W4297389715 hasAuthorship W4297389715A5046989635 @default.
• W4297389715 hasAuthorship W4297389715A5047575606 @default.
• W4297389715 hasAuthorship W4297389715A5049556471 @default.
• W4297389715 hasAuthorship W4297389715A5049803192 @default.
• W4297389715 hasAuthorship W4297389715A5057323751 @default.
• W4297389715 hasAuthorship W4297389715A5067604014 @default.
• W4297389715 hasAuthorship W4297389715A5077166961 @default.
• W4297389715 hasAuthorship W4297389715A5082245729 @default.
• W4297389715 hasConcept C104317684 @default.
• W4297389715 hasConcept C109159458 @default.
• W4297389715 hasConcept C126322002 @default.
• W4297389715 hasConcept C141071460 @default.
• W4297389715 hasConcept C185592680 @default.
• W4297389715 hasConcept C207103383 @default.
• W4297389715 hasConcept C2776601000 @default.
• W4297389715 hasConcept C2776694085 @default.
• W4297389715 hasConcept C2777408962 @default.
• W4297389715 hasConcept C2780775027 @default.
• W4297389715 hasConcept C2781121885 @default.
• W4297389715 hasConcept C28328180 @default.
• W4297389715 hasConcept C2911091166 @default.
• W4297389715 hasConcept C2993713153 @default.
• W4297389715 hasConcept C38180746 @default.
• W4297389715 hasConcept C44249647 @default.

• next