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- W4297394911 abstract "Acinetobacter baumannii causes multi-system diseases in both nosocomial settings and a pre-disposed general population. The bacterium is not only desiccation-resistant but also notoriously resistant to multiple antibiotics and drugs of last resort including carbapenem, colistin, and sulbactam. The World Health Organization has categorized carbapenem-resistant A. baumannii at the top of its critical pathogen list in a bid to direct urgent countermeasure development. Several early-stage vaccines have shown a range of efficacies in healthy mice, but no vaccine candidates have advanced into clinical trials. Herein, we report our findings that both an ionizing γ-radiation-inactivated and a non-ionizing ultraviolet C-inactivated whole-cell vaccine candidate protects neutropenic mice from pulmonary challenge with virulent AB5075, a particularly pathogenic isolate. In addition, we demonstrate that a humoral response is sufficient for this protection via the passive immunization of neutropenic mice." @default.
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- W4297394911 date "2022-09-27" @default.
- W4297394911 modified "2023-09-30" @default.
- W4297394911 title "Whole-cell vaccine candidates induce a protective response against virulent Acinetobacter baumannii" @default.
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- W4297394911 doi "https://doi.org/10.3389/fimmu.2022.941010" @default.
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