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• W4297424887 abstract "ABSTRACT Objective To assess the presence of brain and systemic inflammation in subjects newly diagnosed with Parkinson’s disease (PD). Background Evidence for a pathophysiologic role of inflammation in PD is growing. However, several key gaps remain as to the role of inflammation in PD, including the extent of immune activation at early stages, potential effects of PD treatments on inflammation, and whether pro-inflammatory signals are associated with clinical features and/or predict more rapid progression. Methods We enrolled subjects with de novo PD (n=58) and age-matched controls (n=62). Subjects underwent clinical assessments, including the Movement Disorder Society-United Parkinson’s Disease rating scale (MDS-UPDRS). Comprehensive cognitive assessment meeting MDS Level II criteria for mild cognitive impairment (MCI) testing was performed. Blood was obtained for flow cytometry and cytokine/chemokine analyses. Subjects underwent imaging with 18 F-DPA-714, a translocator protein 18kd (TSPO) ligand, and lumbar puncture if eligible and consented. Results Baseline demographics and medical history were comparable between groups. PD subjects showed significant differences in University of Pennsylvania Smell Identification Test, Schwab and England Activities of Daily Living, Scales for Outcomes in PD autonomic dysfunction, and MDS-UPDRS scores. Cognitive testing demonstrated significant differences in cognitive composite, executive function, and visuospatial domain scores at baseline. PET imaging showed increased 18 F-DPA-714 signal in PD subjects. 18 F-DPA-714 signal correlated with several cognitive measures and some chemokines. Conclusions 18 F-DPA-714 imaging demonstrated increased central inflammation in de novo PD subjects compared to controls. Longitudinal follow-up will be important to determine whether the presence of inflammation predicts cognitive decline." @default.
• W4297424887 created "2022-09-28" @default.
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• W4297424887 date "2022-09-23" @default.
• W4297424887 modified "2023-09-30" @default.
• W4297424887 title "Brain and systemic inflammation in <i>de novo</i> Parkinson’s disease" @default.
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• W4297424887 doi "https://doi.org/10.1101/2022.09.21.22280194" @default.
• W4297424887 hasPublicationYear "2022" @default.
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