Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297441271> ?p ?o ?g. }
- W4297441271 endingPage "3515" @default.
- W4297441271 startingPage "3504" @default.
- W4297441271 abstract "Protein nanocages have emerged as an important engineering platform for biotechnological and biomedical applications. Among naturally occurring protein cages, encapsulin nanocompartments have recently gained prominence due to their favorable physico-chemical properties, ease of shell modification, and highly efficient and selective intrinsic protein packaging capabilities. Here, we expand encapsulin function by designing and characterizing encapsulins for concurrent RNA and protein encapsulation in vivo. Our strategy is based on modifying encapsulin shells with nucleic acid-binding peptides without disrupting the native protein packaging mechanism. We show that our engineered encapsulins reliably self-assemble in vivo, are capable of efficient size-selective in vivo RNA packaging, can simultaneously load multiple functional RNAs, and can be used for concurrent in vivo packaging of RNA and protein. Our engineered encapsulation platform has potential for codelivery of therapeutic RNAs and proteins to elicit synergistic effects and as a modular tool for other biotechnological applications." @default.
- W4297441271 created "2022-09-28" @default.
- W4297441271 creator A5016464843 @default.
- W4297441271 creator A5022307929 @default.
- W4297441271 date "2022-09-28" @default.
- W4297441271 modified "2023-10-16" @default.
- W4297441271 title "Engineered Protein Nanocages for Concurrent RNA and Protein Packaging In Vivo" @default.
- W4297441271 cites W1502474321 @default.
- W4297441271 cites W1747602556 @default.
- W4297441271 cites W1952915322 @default.
- W4297441271 cites W1964146045 @default.
- W4297441271 cites W1983390804 @default.
- W4297441271 cites W2025563408 @default.
- W4297441271 cites W2033787987 @default.
- W4297441271 cites W2043305798 @default.
- W4297441271 cites W2046182783 @default.
- W4297441271 cites W2050933887 @default.
- W4297441271 cites W2055414401 @default.
- W4297441271 cites W2075383643 @default.
- W4297441271 cites W2080070405 @default.
- W4297441271 cites W2092706417 @default.
- W4297441271 cites W2099753372 @default.
- W4297441271 cites W2110117963 @default.
- W4297441271 cites W2147537878 @default.
- W4297441271 cites W2162802735 @default.
- W4297441271 cites W2284750113 @default.
- W4297441271 cites W2314607611 @default.
- W4297441271 cites W2322790863 @default.
- W4297441271 cites W2402487971 @default.
- W4297441271 cites W2402587203 @default.
- W4297441271 cites W2419067390 @default.
- W4297441271 cites W2461920483 @default.
- W4297441271 cites W2467743933 @default.
- W4297441271 cites W2491008760 @default.
- W4297441271 cites W2558264208 @default.
- W4297441271 cites W2559077904 @default.
- W4297441271 cites W2574449912 @default.
- W4297441271 cites W2581295262 @default.
- W4297441271 cites W2589560199 @default.
- W4297441271 cites W2593304916 @default.
- W4297441271 cites W2594133976 @default.
- W4297441271 cites W2605029885 @default.
- W4297441271 cites W2630192492 @default.
- W4297441271 cites W2739366153 @default.
- W4297441271 cites W2741659744 @default.
- W4297441271 cites W2762090103 @default.
- W4297441271 cites W2776200197 @default.
- W4297441271 cites W2780466662 @default.
- W4297441271 cites W2799957688 @default.
- W4297441271 cites W2799961143 @default.
- W4297441271 cites W2802233281 @default.
- W4297441271 cites W2802978170 @default.
- W4297441271 cites W2803212691 @default.
- W4297441271 cites W2805226653 @default.
- W4297441271 cites W2887243151 @default.
- W4297441271 cites W2895155188 @default.
- W4297441271 cites W2899489314 @default.
- W4297441271 cites W2918342704 @default.
- W4297441271 cites W2947812559 @default.
- W4297441271 cites W2952923211 @default.
- W4297441271 cites W2954897812 @default.
- W4297441271 cites W2960879452 @default.
- W4297441271 cites W2962608495 @default.
- W4297441271 cites W2985264717 @default.
- W4297441271 cites W2996035724 @default.
- W4297441271 cites W2997202910 @default.
- W4297441271 cites W3003747672 @default.
- W4297441271 cites W3004266179 @default.
- W4297441271 cites W3005566802 @default.
- W4297441271 cites W3020287176 @default.
- W4297441271 cites W3030200736 @default.
- W4297441271 cites W3038956139 @default.
- W4297441271 cites W3042827389 @default.
- W4297441271 cites W3095932762 @default.
- W4297441271 cites W3097051295 @default.
- W4297441271 cites W3099070211 @default.
- W4297441271 cites W3107142905 @default.
- W4297441271 cites W3132217836 @default.
- W4297441271 cites W3135564133 @default.
- W4297441271 cites W3138711941 @default.
- W4297441271 cites W3139196242 @default.
- W4297441271 cites W3140202536 @default.
- W4297441271 cites W3152922933 @default.
- W4297441271 cites W3158191005 @default.
- W4297441271 cites W3166788152 @default.
- W4297441271 cites W3171076461 @default.
- W4297441271 cites W3192984354 @default.
- W4297441271 cites W3194946949 @default.
- W4297441271 cites W3195823702 @default.
- W4297441271 cites W3197558278 @default.
- W4297441271 cites W3200176065 @default.
- W4297441271 cites W3201039571 @default.
- W4297441271 cites W3202833114 @default.
- W4297441271 cites W3204862058 @default.
- W4297441271 cites W3207334479 @default.
- W4297441271 cites W3212179177 @default.
- W4297441271 cites W3212361174 @default.
- W4297441271 cites W4205147552 @default.