FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297445594> ?p ?o ?g. }

• W4297445594 abstract "Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease that leads to the death of motor and cortical neurons. The clinical manifestations of ALS are heterogenous, and efficacious treatments to significantly slow the progression of the disease are lacking. Cortical hyper-excitability is observed pre-symptomatically across disease-causative genetic variants, as well as in the early stages of sporadic ALS, and typically precedes motor neuron involvement and overt neurodegeneration. The causes of cortical hyper-excitability are not yet fully understood but is mainly agreed to be an early event. The identification of the nucleotide repeat expansion (GGGGCC) n in the C9ORF72 gene has provided evidence that ALS and another neurodegenerative disease, frontotemporal dementia (FTD), are part of a disease spectrum with common genetic origins. ALS and FTD are diseases in which synaptic dysfunction is reported throughout disease onset and stages of progression. It has become apparent that ALS/FTD-causative genes, such as C9ORF72 , may have roles in maintaining the normal physiology of the synapse, as mutations in these genes often manifest in synaptic dysfunction. Here we review the dysfunctions of the central nervous system synapses associated with the nucleotide repeat expansion in C9ORF72 observed in patients, organismal, and cellular models of ALS and FTD." @default.
• W4297445594 created "2022-09-28" @default.
• W4297445594 creator A5004249732 @default.
• W4297445594 creator A5012545482 @default.
• W4297445594 creator A5024532660 @default.
• W4297445594 creator A5078857071 @default.
• W4297445594 date "2022-09-16" @default.
• W4297445594 modified "2023-10-10" @default.
• W4297445594 title "Breakdown of the central synapses in C9orf72-linked ALS/FTD" @default.
• W4297445594 cites W1452644309 @default.
• W4297445594 cites W1587505135 @default.
• W4297445594 cites W1590729586 @default.
• W4297445594 cites W1607372012 @default.
• W4297445594 cites W1737847196 @default.
• W4297445594 cites W1796096082 @default.
• W4297445594 cites W1797572428 @default.
• W4297445594 cites W1833846911 @default.
• W4297445594 cites W1943940733 @default.
• W4297445594 cites W1968692604 @default.
• W4297445594 cites W1971639674 @default.
• W4297445594 cites W1979886157 @default.
• W4297445594 cites W1986986092 @default.
• W4297445594 cites W1988787781 @default.
• W4297445594 cites W1988931872 @default.
• W4297445594 cites W1996576454 @default.
• W4297445594 cites W2007356342 @default.
• W4297445594 cites W2009558810 @default.
• W4297445594 cites W2011209444 @default.
• W4297445594 cites W2013488820 @default.
• W4297445594 cites W2014898107 @default.
• W4297445594 cites W2031132507 @default.
• W4297445594 cites W2032269048 @default.
• W4297445594 cites W2046433440 @default.
• W4297445594 cites W2048764230 @default.
• W4297445594 cites W2049342904 @default.
• W4297445594 cites W2049866432 @default.
• W4297445594 cites W2050066016 @default.
• W4297445594 cites W2054542675 @default.
• W4297445594 cites W2058313056 @default.
• W4297445594 cites W2060127255 @default.
• W4297445594 cites W2060799374 @default.
• W4297445594 cites W2063996210 @default.
• W4297445594 cites W2065219073 @default.
• W4297445594 cites W2065432433 @default.
• W4297445594 cites W2068742937 @default.
• W4297445594 cites W2071471772 @default.
• W4297445594 cites W2079457709 @default.
• W4297445594 cites W2085204538 @default.
• W4297445594 cites W2087465947 @default.
• W4297445594 cites W2088483634 @default.
• W4297445594 cites W2096386031 @default.
• W4297445594 cites W2099036911 @default.
• W4297445594 cites W2099956943 @default.
• W4297445594 cites W2114872355 @default.
• W4297445594 cites W2115900486 @default.
• W4297445594 cites W2117890656 @default.
• W4297445594 cites W2123613114 @default.
• W4297445594 cites W2124979734 @default.
• W4297445594 cites W2135718342 @default.
• W4297445594 cites W2137434543 @default.
• W4297445594 cites W2139087276 @default.
• W4297445594 cites W2144993965 @default.
• W4297445594 cites W2150523249 @default.
• W4297445594 cites W2153760714 @default.
• W4297445594 cites W2154945114 @default.
• W4297445594 cites W2164522863 @default.
• W4297445594 cites W2187620259 @default.
• W4297445594 cites W2195925510 @default.
• W4297445594 cites W2340195634 @default.
• W4297445594 cites W2346276182 @default.
• W4297445594 cites W2407224737 @default.
• W4297445594 cites W2419624019 @default.
• W4297445594 cites W2460778061 @default.
• W4297445594 cites W2469933906 @default.
• W4297445594 cites W2511373877 @default.
• W4297445594 cites W2520605819 @default.
• W4297445594 cites W2520899139 @default.
• W4297445594 cites W2522741011 @default.
• W4297445594 cites W2529841186 @default.
• W4297445594 cites W2530167760 @default.
• W4297445594 cites W2556818673 @default.
• W4297445594 cites W2557973650 @default.
• W4297445594 cites W2586257265 @default.
• W4297445594 cites W2586663476 @default.
• W4297445594 cites W2592387132 @default.
• W4297445594 cites W2620577788 @default.
• W4297445594 cites W2738673892 @default.
• W4297445594 cites W2740621742 @default.
• W4297445594 cites W2745961577 @default.
• W4297445594 cites W2776270597 @default.
• W4297445594 cites W2782124946 @default.
• W4297445594 cites W2785267239 @default.
• W4297445594 cites W2785309619 @default.
• W4297445594 cites W2787234767 @default.
• W4297445594 cites W2790884408 @default.
• W4297445594 cites W2797627650 @default.
• W4297445594 cites W2883733625 @default.
• W4297445594 cites W2885472413 @default.
• W4297445594 cites W2887838825 @default.
• W4297445594 cites W2898137459 @default.

• next