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- W4297445765 abstract "Abstract Background: We hypothesized that the measured expiratory time constant (TauE) could be a bedside parameter for the evaluation of positive end-expiratory pressure (PEEP) settings in mechanically ventilated COVID-19 patients during pressure-controlled ventilation (PCV). Methods : A prospective study was conducted including consecutively admitted adults (n = 16) with COVID-19-related ARDS requiring mechanical ventilation. A PEEP titration using PCV with a fixed driving pressure of 14 cmH2O was performed and TauE recorded at each PEEP level (0 to 18 cmH2O) in prone (n = 29) or supine (n = 24) positions. The PEEP setting with the highest TauE (TauEMAX) was considered to represent the best tradeoff between recruitment and overdistention. Results : Two groups of patterns were observed in the TauE plots: recruitable (R) (75%) and nonrecruitable (NR) (25%). In the R group, the optimal PEEP and PEEP ranges were 8±3 cmH2O and 6-10 cmH2O for the prone position and 9±3 cmH2O and 7-12 cmH2O for the supine position. In the NR group, the optimal PEEP and PEEP ranges were 4±4 cmH2O and 1-8 cmH2O for the prone position and 5±3 cmH2O and 1-7 cmH2O for the supine position, respectively. The R group showed significantly higher optimal PEEP (p<0.004) and PEEP ranges (p<0.001) than the NR group. Forty-five percent of measurements resulted in the most optimal PEEP being significantly different between the positions (p < 0.01). Conclusions : TauE may be a novel method to assess PEEP levels. There was wide variation in patient responses to PEEP, which indicates the need for personalized evaluation." @default.
- W4297445765 created "2022-09-28" @default.
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- W4297445765 date "2022-09-16" @default.
- W4297445765 modified "2023-10-18" @default.
- W4297445765 title "Time constant to determine PEEP levels in mechanically ventilated COVID-19 ARDS: a feasibility study" @default.
- W4297445765 doi "https://doi.org/10.21203/rs.3.rs-2023535/v1" @default.
- W4297445765 hasPublicationYear "2022" @default.
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