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- W4297458198 abstract "The evolution of endothermy was instrumental to the diversification of birds and mammals, but the energetic demands of maintaining high body temperature could offset the advantages of endothermy in some environments. We hypothesized that reductions in body temperature help high-altitude natives overcome the metabolic challenges of cold and hypoxia in their native environment. Deer mice (Peromyscus maniculatus) from high-altitude and low-altitude populations were bred in captivity to the second generation and were acclimated as adults to warm normoxia or cold hypoxia. Subcutaneous temperature (Tsub, used as a proxy for body temperature) and cardiovascular function were then measured throughout the diel cycle using biotelemetry. Cold hypoxia increased metabolic demands, as reflected by increased food consumption and heart rate (associated with reduced vagal tone). These increased metabolic demands were offset by plastic reductions in Tsub (approx. 2°C) in response to cold hypoxia, and highlanders had lower Tsub (approx. 1°C) than lowlanders in both environmental treatments. Empirical and theoretical evidence suggested that these reductions could together reduce metabolic demands by approximately 10-30%. Therefore, plastic and evolved reductions in body temperature can help mammals overcome the metabolic challenges at high altitude and may be a valuable energy-saving strategy in some non-hibernating endotherms in extreme environments." @default.
- W4297458198 created "2022-09-29" @default.
- W4297458198 creator A5063564535 @default.
- W4297458198 creator A5074069112 @default.
- W4297458198 date "2022-09-28" @default.
- W4297458198 modified "2023-10-08" @default.
- W4297458198 title "Evolved reductions in body temperature and the metabolic costs of thermoregulation in deer mice native to high altitude" @default.
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- W4297458198 doi "https://doi.org/10.1098/rspb.2022.1553" @default.
- W4297458198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36168757" @default.
- W4297458198 hasPublicationYear "2022" @default.
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