FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297458637> ?p ?o ?g. }

• W4297458637 endingPage "1110" @default.
• W4297458637 startingPage "1110" @default.
• W4297458637 abstract "Importance Self-reported trauma exposure has consistently been found to be a risk factor for major depressive disorder (MDD), and several studies have reported interactions with genetic liability. To date, most studies have examined gene-environment interactions with trauma exposure using genome-wide variants (single-nucleotide variations [SNVs]) or polygenic scores, both typically capturing less than 3% of phenotypic risk variance. Objective To reexamine genome-by-trauma interaction associations using genetic measures using all available genotyped data and thus, maximizing accounted variance. Design, Setting, and Participants The UK Biobank study was conducted from April 2007 to May 1, 2016 (follow-up mental health questionnaire). The current study used available cross-sectional genomic and trauma exposure data from UK Biobank. Participants who completed the mental health questionnaire and had available genetic, trauma experience, depressive symptoms, and/or neuroticism information were included. Data were analyzed from April 1 to August 30, 2021. Exposures Trauma and genome-by-trauma exposure interactions. Main Outcomes and Measures Measures of self-reported depression, neuroticism, and trauma exposure with whole-genome SNV data are available from the UK Biobank study. Here, a mixed-model statistical approach using genetic, trauma exposure, and genome-by-trauma exposure interaction similarity matrices was used to explore sources of variation in depression and neuroticism. Results Analyses were conducted on 148 129 participants (mean [SD] age, 56 [7] years) of which 76 995 were female (52.0%). The study approach estimated the heritability (SE) of MDD to be approximately 0.160 (0.016). Subtypes of self-reported trauma exposure (catastrophic, adult, childhood, and full trauma) accounted for a significant proportion of the variance of MDD, with heritability (SE) ranging from 0.056 (0.013) to 0.176 (0.025). The proportion of MDD risk variance accounted for by significant genome-by-trauma interaction revealed estimates (SD) ranging from 0.074 (0.006) to 0.201 (0.009). Results from sex-specific analyses found genome-by-trauma interaction variance estimates approximately 5-fold greater for MDD in male participants (0.441 [0.018]) than in female participants (0.086 [0.009]). Conclusions and Relevance This cross-sectional study used an approach combining all genome-wide SNV data when exploring genome-by-trauma interactions in individuals with MDD; findings suggest that such interactions were associated with depression manifestation. Genome-by-trauma interaction accounts for greater trait variance in male individuals, which points to potential differences in depression etiology between the sexes. The methodology used in this study can be extrapolated to other environmental factors to identify modifiable risk environments and at-risk groups to target with interventions." @default.
• W4297458637 created "2022-09-29" @default.
• W4297458637 creator A5001226865 @default.
• W4297458637 creator A5006934895 @default.
• W4297458637 creator A5074925624 @default.
• W4297458637 creator A5080112384 @default.
• W4297458637 creator A5085171662 @default.
• W4297458637 creator A5089422952 @default.
• W4297458637 date "2022-11-01" @default.
• W4297458637 modified "2023-09-30" @default.
• W4297458637 title "Genome-by-Trauma Exposure Interactions in Adults With Depression in the UK Biobank" @default.
• W4297458637 cites W1855058198 @default.
• W4297458637 cites W1980991473 @default.
• W4297458637 cites W1984971990 @default.
• W4297458637 cites W1997338841 @default.
• W4297458637 cites W2033151532 @default.
• W4297458637 cites W2086799994 @default.
• W4297458637 cites W2098667423 @default.
• W4297458637 cites W2108344016 @default.
• W4297458637 cites W2114879270 @default.
• W4297458637 cites W2118826874 @default.
• W4297458637 cites W2149016179 @default.
• W4297458637 cites W2150164117 @default.
• W4297458637 cites W2153876142 @default.
• W4297458637 cites W2155785248 @default.
• W4297458637 cites W2167638767 @default.
• W4297458637 cites W2170197613 @default.
• W4297458637 cites W2174683342 @default.
• W4297458637 cites W2188707104 @default.
• W4297458637 cites W2283684210 @default.
• W4297458637 cites W2299694795 @default.
• W4297458637 cites W2323517150 @default.
• W4297458637 cites W2472243732 @default.
• W4297458637 cites W2504011626 @default.
• W4297458637 cites W2534627208 @default.
• W4297458637 cites W2587307063 @default.
• W4297458637 cites W2598022332 @default.
• W4297458637 cites W2625101985 @default.
• W4297458637 cites W2625632191 @default.
• W4297458637 cites W2735059498 @default.
• W4297458637 cites W2738082385 @default.
• W4297458637 cites W2740637836 @default.
• W4297458637 cites W2758725377 @default.
• W4297458637 cites W2903051174 @default.
• W4297458637 cites W2904951921 @default.
• W4297458637 cites W2911487850 @default.
• W4297458637 cites W2952071100 @default.
• W4297458637 cites W2952784561 @default.
• W4297458637 cites W2988793804 @default.
• W4297458637 cites W3004083863 @default.
• W4297458637 cites W3016610742 @default.
• W4297458637 cites W3114167483 @default.
• W4297458637 cites W3117291333 @default.
• W4297458637 cites W3144245521 @default.
• W4297458637 cites W3160881125 @default.
• W4297458637 cites W3187043744 @default.
• W4297458637 cites W3198791306 @default.
• W4297458637 cites W4239105050 @default.
• W4297458637 cites W4241294122 @default.
• W4297458637 cites W4245125537 @default.
• W4297458637 cites W4248926393 @default.
• W4297458637 cites W4252109423 @default.
• W4297458637 cites W4289545966 @default.
• W4297458637 doi "https://doi.org/10.1001/jamapsychiatry.2022.2983" @default.
• W4297458637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36169986" @default.
• W4297458637 hasPublicationYear "2022" @default.
• W4297458637 type Work @default.
• W4297458637 citedByCount "4" @default.
• W4297458637 countsByYear W42974586372023 @default.
• W4297458637 crossrefType "journal-article" @default.
• W4297458637 hasAuthorship W4297458637A5001226865 @default.
• W4297458637 hasAuthorship W4297458637A5006934895 @default.
• W4297458637 hasAuthorship W4297458637A5074925624 @default.
• W4297458637 hasAuthorship W4297458637A5080112384 @default.
• W4297458637 hasAuthorship W4297458637A5085171662 @default.
• W4297458637 hasAuthorship W4297458637A5089422952 @default.
• W4297458637 hasBestOaLocation W42974586371 @default.
• W4297458637 hasConcept C116567970 @default.
• W4297458637 hasConcept C118552586 @default.
• W4297458637 hasConcept C134362201 @default.
• W4297458637 hasConcept C139719470 @default.
• W4297458637 hasConcept C15744967 @default.
• W4297458637 hasConcept C161890455 @default.
• W4297458637 hasConcept C162324750 @default.
• W4297458637 hasConcept C169594400 @default.
• W4297458637 hasConcept C187288502 @default.
• W4297458637 hasConcept C2776867660 @default.
• W4297458637 hasConcept C2780051608 @default.
• W4297458637 hasConcept C2780733359 @default.
• W4297458637 hasConcept C54355233 @default.
• W4297458637 hasConcept C70410870 @default.
• W4297458637 hasConcept C71924100 @default.
• W4297458637 hasConcept C77805123 @default.
• W4297458637 hasConcept C86803240 @default.
• W4297458637 hasConcept C94612546 @default.
• W4297458637 hasConceptScore W4297458637C116567970 @default.
• W4297458637 hasConceptScore W4297458637C118552586 @default.
• W4297458637 hasConceptScore W4297458637C134362201 @default.

• next