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• W4297486087 endingPage "12346" @default.
• W4297486087 startingPage "12346" @default.
• W4297486087 abstract "Cyanobacteria of the Nostoc genus belong to the most prolific sources of bioactive metabolites. In our previous study on Nostoc edaphicum strain CCNP1411, the occurrence of cyanopeptolins and nostocyclopeptides was documented. In the current work, the production of anabaenopeptins (APs) by the strain was studied using genetic and chemical methods. Compatibility between the analysis of the apt gene cluster and the structure of the identified APs was found. Three of the APs, including two new variants, were isolated as pure compounds and tested against four serine proteases and carboxypeptidase A (CPA). The in vitro enzymatic assays showed a typical activity of this class of cyanopeptides, i.e., the most pronounced effects were observed in the case of CPA. The activity of the detected compounds against important metabolic enzymes confirms the pharmaceutical potential of anabaenopeptins." @default.
• W4297486087 created "2022-09-29" @default.
• W4297486087 creator A5002076589 @default.
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• W4297486087 creator A5050171487 @default.
• W4297486087 creator A5060642903 @default.
• W4297486087 date "2022-09-28" @default.
• W4297486087 modified "2023-10-03" @default.
• W4297486087 title "Anabaenopeptins from Nostoc edaphicum CCNP1411" @default.
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• W4297486087 doi "https://doi.org/10.3390/ijerph191912346" @default.
• W4297486087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36231642" @default.
• W4297486087 hasPublicationYear "2022" @default.

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