FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297488596> ?p ?o ?g. }

• W4297488596 endingPage "191" @default.
• W4297488596 startingPage "184" @default.
• W4297488596 abstract "Background: This study aims to investigate the effects of different direct oral anticoagulants on experimental renal injury induced by temporary infrarenal aortic occlusion. Methods: A total of 35 male Wistar rats (250 to 350 g) were randomly allocated to any of the five groups: sham, ischemia-reperfusion, rivaroxaban, dabigatran, and apixaban groups. Sham group underwent median laparotomy. Ischemia-reperfusion group was given saline gavage for one week. Animals in the other groups received rivaroxaban (3 mg/kg), dabigatran (15 mg/kg), or apixaban (10 mg/kg) daily once for one week via oral gavage. The infrarenal abdominal aorta was clamped for 60 min, and reperfusion was maintained for 120 min in the ischemia-reperfusion, rivaroxaban, dabigatran, and apixaban groups. At the end of reperfusion, kidneys were harvested for biochemical and histopathological analysis. Results: Renal total antioxidant capacity was reduced, and total oxidant status, interleukin-1 beta, and tumor necrosis factor-alpha were elevated in the ischemia-reperfusion group, compared to the sham group (p<0.005). Histological damage scores were also higher in the ischemia-reperfusion group (p<0.005). Administration of direct oral anticoagulants caused an increase of total antioxidant capacity and reduction of total oxidant status, tumor necrosis factor-alpha, and interleukin-1 beta in the rivaroxaban, dabigatran, and apixaban groups compared to the ischemia-reperfusion group (p<0.005). Histological damage scores were lower in the rivaroxaban and dabigatran groups than the ischemia-reperfusion group scores (p<0.005). Conclusion: Direct oral anticoagulants reduce aortic clamping-induced renal tissue oxidation and inflammation. Rivaroxaban and dabigatran attenuate ischemia-reperfusion-related histological damage in kidneys." @default.
• W4297488596 created "2022-09-29" @default.
• W4297488596 creator A5007779029 @default.
• W4297488596 creator A5014398022 @default.
• W4297488596 creator A5031053800 @default.
• W4297488596 creator A5031636269 @default.
• W4297488596 creator A5068992787 @default.
• W4297488596 creator A5070225505 @default.
• W4297488596 creator A5080490732 @default.
• W4297488596 date "2022-04-01" @default.
• W4297488596 modified "2023-09-30" @default.
• W4297488596 title "Direct oral anticoagulant agents attenuate temporary aortic occlusion-induced renal oxidative and inflammatory responses in rats" @default.
• W4297488596 cites W1479868810 @default.
• W4297488596 cites W1963938486 @default.
• W4297488596 cites W2004274286 @default.
• W4297488596 cites W204998232 @default.
• W4297488596 cites W2055947109 @default.
• W4297488596 cites W2066269792 @default.
• W4297488596 cites W2080051897 @default.
• W4297488596 cites W2080937631 @default.
• W4297488596 cites W2106692330 @default.
• W4297488596 cites W2138329655 @default.
• W4297488596 cites W2164965999 @default.
• W4297488596 cites W2170597525 @default.
• W4297488596 cites W2302034839 @default.
• W4297488596 cites W2323877640 @default.
• W4297488596 cites W2342473733 @default.
• W4297488596 cites W2765853891 @default.
• W4297488596 cites W2810245930 @default.
• W4297488596 cites W2883958957 @default.
• W4297488596 cites W2897185026 @default.
• W4297488596 cites W2899449506 @default.
• W4297488596 cites W2935041100 @default.
• W4297488596 cites W2938493336 @default.
• W4297488596 cites W2980770901 @default.
• W4297488596 cites W2998650899 @default.
• W4297488596 cites W3009083611 @default.
• W4297488596 cites W3113586081 @default.
• W4297488596 cites W4247943480 @default.
• W4297488596 doi "https://doi.org/10.5606/tgkdc.dergisi.2022.22831" @default.
• W4297488596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36168569" @default.
• W4297488596 hasPublicationYear "2022" @default.
• W4297488596 type Work @default.
• W4297488596 citedByCount "1" @default.
• W4297488596 countsByYear W42974885962023 @default.
• W4297488596 crossrefType "journal-article" @default.
• W4297488596 hasAuthorship W4297488596A5007779029 @default.
• W4297488596 hasAuthorship W4297488596A5014398022 @default.
• W4297488596 hasAuthorship W4297488596A5031053800 @default.
• W4297488596 hasAuthorship W4297488596A5031636269 @default.
• W4297488596 hasAuthorship W4297488596A5068992787 @default.
• W4297488596 hasAuthorship W4297488596A5070225505 @default.
• W4297488596 hasAuthorship W4297488596A5080490732 @default.
• W4297488596 hasBestOaLocation W42974885961 @default.
• W4297488596 hasConcept C126322002 @default.
• W4297488596 hasConcept C126894567 @default.
• W4297488596 hasConcept C2776301958 @default.
• W4297488596 hasConcept C2778661090 @default.
• W4297488596 hasConcept C2778810321 @default.
• W4297488596 hasConcept C2779161974 @default.
• W4297488596 hasConcept C2780114680 @default.
• W4297488596 hasConcept C2780638905 @default.
• W4297488596 hasConcept C2780721119 @default.
• W4297488596 hasConcept C42219234 @default.
• W4297488596 hasConcept C541997718 @default.
• W4297488596 hasConcept C71924100 @default.
• W4297488596 hasConcept C98274493 @default.
• W4297488596 hasConceptScore W4297488596C126322002 @default.
• W4297488596 hasConceptScore W4297488596C126894567 @default.
• W4297488596 hasConceptScore W4297488596C2776301958 @default.
• W4297488596 hasConceptScore W4297488596C2778661090 @default.
• W4297488596 hasConceptScore W4297488596C2778810321 @default.
• W4297488596 hasConceptScore W4297488596C2779161974 @default.
• W4297488596 hasConceptScore W4297488596C2780114680 @default.
• W4297488596 hasConceptScore W4297488596C2780638905 @default.
• W4297488596 hasConceptScore W4297488596C2780721119 @default.
• W4297488596 hasConceptScore W4297488596C42219234 @default.
• W4297488596 hasConceptScore W4297488596C541997718 @default.
• W4297488596 hasConceptScore W4297488596C71924100 @default.
• W4297488596 hasConceptScore W4297488596C98274493 @default.
• W4297488596 hasIssue "2" @default.
• W4297488596 hasLocation W42974885961 @default.
• W4297488596 hasLocation W42974885962 @default.
• W4297488596 hasLocation W42974885963 @default.
• W4297488596 hasOpenAccess W4297488596 @default.
• W4297488596 hasPrimaryLocation W42974885961 @default.
• W4297488596 hasRelatedWork W1436836526 @default.
• W4297488596 hasRelatedWork W1997499869 @default.
• W4297488596 hasRelatedWork W2030888547 @default.
• W4297488596 hasRelatedWork W2046188252 @default.
• W4297488596 hasRelatedWork W2083901189 @default.
• W4297488596 hasRelatedWork W2093259736 @default.
• W4297488596 hasRelatedWork W2134062404 @default.
• W4297488596 hasRelatedWork W2603244127 @default.
• W4297488596 hasRelatedWork W2789972226 @default.
• W4297488596 hasRelatedWork W3010727983 @default.
• W4297488596 hasVolume "30" @default.
• W4297488596 isParatext "false" @default.

• next