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• W4297493963 endingPage "340449" @default.
• W4297493963 startingPage "340449" @default.
• W4297493963 abstract "Pseudomonas aeruginosa (P. aeruginosa) is one of the most common bacteria in nosocomial infection. Here, a novel fluorescence biosensor based on double-stranded DNA branch migration-induced hybridization chain reaction (HCR) and DNAzyme feedback circuit was constructed for sensitive detection of P. aeruginosa. The binding of P. aeruginosa with its aptamer on a DNA three-way junction structure initiated the double-stranded DNA branch migration to form two DNA Y junction structures. One DNA Y junction structure opened the fluorescence-labelled DNA hairpins and triggered the HCR. The other DNA Y junction structure formed a double-stranded DNAzyme and cleaved the specific ribonucleotide site, producing new triggering probes to start the next cycle of the double-stranded DNA branch migration. Ultimately, a large number of DNA Y junction structures were produced, which greatly promoted signal amplification. Under optimized conditions, the proposed biosensor detected a wide linearity range of 102-107 CFU mL-1, and the limit of detection was 37 CFU mL-1 (S/N = 3). The recovery test results indicated that the biosensor has promising clinical application potential. Because of the simultaneous initiation of the HCR and the DNAzyme feedback circuit through the double-stranded DNA branch migration, the constructed biosensor provided an ideal platform for pathogenic bacteria detection without protein enzymes and complex signal amplification procedures." @default.
• W4297493963 created "2022-09-29" @default.
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• W4297493963 date "2022-11-01" @default.
• W4297493963 modified "2023-10-03" @default.
• W4297493963 title "A novel fluorescence biosensor based on double-stranded DNA branch migration-induced HCR and DNAzyme feedback circuit for sensitive detection of Pseudomonas aeruginosa (clean version)" @default.
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• W4297493963 doi "https://doi.org/10.1016/j.aca.2022.340449" @default.
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