Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297496620> ?p ?o ?g. }
- W4297496620 endingPage "1966.e10" @default.
- W4297496620 startingPage "1953" @default.
- W4297496620 abstract "A major challenge in adoptive T cell immunotherapy is the discovery of natural T cell receptors (TCRs) with high activity and specificity to tumor antigens. Engineering synthetic TCRs for increased tumor antigen recognition is complicated by the risk of introducing cross-reactivity and by the poor correlation that can exist between binding affinity and activity of TCRs in response to antigen (peptide-MHC). Here, we developed TCR-Engine, a method combining genome editing, computational design, and deep sequencing to engineer the functional activity and specificity of TCRs on the surface of a human T cell line at high throughput. We applied TCR-Engine to successfully engineer synthetic TCRs for increased potency and specificity to a clinically relevant tumor-associated antigen (MAGE-A3) and validated their translational potential through multiple in vitro and in vivo assessments of safety and efficacy. Thus, TCR-Engine represents a valuable technology for engineering of safe and potent synthetic TCRs for immunotherapy applications." @default.
- W4297496620 created "2022-09-29" @default.
- W4297496620 creator A5011771076 @default.
- W4297496620 creator A5015318430 @default.
- W4297496620 creator A5017754496 @default.
- W4297496620 creator A5034706637 @default.
- W4297496620 creator A5036433120 @default.
- W4297496620 creator A5038309538 @default.
- W4297496620 creator A5050294297 @default.
- W4297496620 creator A5052563437 @default.
- W4297496620 creator A5053602616 @default.
- W4297496620 creator A5060105697 @default.
- W4297496620 creator A5068350308 @default.
- W4297496620 creator A5072818273 @default.
- W4297496620 creator A5079106817 @default.
- W4297496620 creator A5087536689 @default.
- W4297496620 date "2022-10-01" @default.
- W4297496620 modified "2023-10-14" @default.
- W4297496620 title "High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity" @default.
- W4297496620 cites W1531789930 @default.
- W4297496620 cites W1656802595 @default.
- W4297496620 cites W1877911682 @default.
- W4297496620 cites W1981964848 @default.
- W4297496620 cites W1983143892 @default.
- W4297496620 cites W1992253391 @default.
- W4297496620 cites W2005274005 @default.
- W4297496620 cites W2020312840 @default.
- W4297496620 cites W2023400295 @default.
- W4297496620 cites W2036632122 @default.
- W4297496620 cites W2048784307 @default.
- W4297496620 cites W2050302632 @default.
- W4297496620 cites W2068767807 @default.
- W4297496620 cites W2070748533 @default.
- W4297496620 cites W2091567124 @default.
- W4297496620 cites W2094652659 @default.
- W4297496620 cites W2098852858 @default.
- W4297496620 cites W2099580557 @default.
- W4297496620 cites W2106582884 @default.
- W4297496620 cites W2116117984 @default.
- W4297496620 cites W2119077423 @default.
- W4297496620 cites W2121315503 @default.
- W4297496620 cites W2125079066 @default.
- W4297496620 cites W2132826139 @default.
- W4297496620 cites W2143626441 @default.
- W4297496620 cites W2159819161 @default.
- W4297496620 cites W2165119413 @default.
- W4297496620 cites W2166213184 @default.
- W4297496620 cites W2177830250 @default.
- W4297496620 cites W2229738114 @default.
- W4297496620 cites W2404396229 @default.
- W4297496620 cites W2530338180 @default.
- W4297496620 cites W2737196618 @default.
- W4297496620 cites W2759958021 @default.
- W4297496620 cites W2767331838 @default.
- W4297496620 cites W2768265551 @default.
- W4297496620 cites W2771306389 @default.
- W4297496620 cites W2778215749 @default.
- W4297496620 cites W2788334670 @default.
- W4297496620 cites W2789710996 @default.
- W4297496620 cites W2818540548 @default.
- W4297496620 cites W2884809460 @default.
- W4297496620 cites W2901331779 @default.
- W4297496620 cites W2916483558 @default.
- W4297496620 cites W2949459510 @default.
- W4297496620 cites W2952354682 @default.
- W4297496620 cites W2981395002 @default.
- W4297496620 cites W2984577051 @default.
- W4297496620 cites W2990304685 @default.
- W4297496620 cites W3004461655 @default.
- W4297496620 cites W3010464142 @default.
- W4297496620 cites W3012355104 @default.
- W4297496620 cites W3021105697 @default.
- W4297496620 cites W4223964264 @default.
- W4297496620 doi "https://doi.org/10.1016/j.immuni.2022.09.004" @default.
- W4297496620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36174557" @default.
- W4297496620 hasPublicationYear "2022" @default.
- W4297496620 type Work @default.
- W4297496620 citedByCount "13" @default.
- W4297496620 countsByYear W42974966202022 @default.
- W4297496620 countsByYear W42974966202023 @default.
- W4297496620 crossrefType "journal-article" @default.
- W4297496620 hasAuthorship W4297496620A5011771076 @default.
- W4297496620 hasAuthorship W4297496620A5015318430 @default.
- W4297496620 hasAuthorship W4297496620A5017754496 @default.
- W4297496620 hasAuthorship W4297496620A5034706637 @default.
- W4297496620 hasAuthorship W4297496620A5036433120 @default.
- W4297496620 hasAuthorship W4297496620A5038309538 @default.
- W4297496620 hasAuthorship W4297496620A5050294297 @default.
- W4297496620 hasAuthorship W4297496620A5052563437 @default.
- W4297496620 hasAuthorship W4297496620A5053602616 @default.
- W4297496620 hasAuthorship W4297496620A5060105697 @default.
- W4297496620 hasAuthorship W4297496620A5068350308 @default.
- W4297496620 hasAuthorship W4297496620A5072818273 @default.
- W4297496620 hasAuthorship W4297496620A5079106817 @default.
- W4297496620 hasAuthorship W4297496620A5087536689 @default.
- W4297496620 hasBestOaLocation W42974966201 @default.
- W4297496620 hasConcept C147483822 @default.
- W4297496620 hasConcept C19317047 @default.