Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297496688> ?p ?o ?g. }
- W4297496688 abstract "Small bowel adenocarcinoma (SBA) is a gastrointestinal malignancy with low incidence but poor prognosis, and its pathogenesis is still unclear. This study aimed to explore potential disease-causing biomarkers of SBA. The gene expression datasets of SBA and normal samples were downloaded from the Gene Expression Omnibus database. First, differential gene expression analysis and weighted gene coexpression network analysis (WGCNA) were performed. Common genes (CGs) were obtained by intersection of differentially expressed genes (DEGs) and optimal modal genes of WGCNA. Subsequently, a protein‒protein interaction network was established to screen hub genes, and target genes were obtained by Lasso regression analysis of hub genes. An SBA risk prediction model was established based on target genes. The prediction accuracy of the model was evaluated by the area under the receiver operating characteristic curve (AUC). The levels of immune cell infiltration and activation of immune pathways were compared between SBA and normal samples using the ggpubr and reshape2 packages. A total of 1058 DEGs were identified. WGCNA showed that the signature gene in the brown module was significantly associated with SBA (p = 7E-17), and 469 CGs were obtained. Four target genes (APOA4, APOB, COL1A2, FN1) were identified and showed excellent prediction of SBA risk (AUC = 0.965). In addition, active dendritic cells and macrophages showed higher infiltration levels in SBA. Meanwhile, the APC_co_stimulation pathway and parainflammation pathway were strongly active in SBA. Four target genes (APOA4, APOB, COL1A2, FN1) may be involved in the pathogenesis of small bowel adenocarcinoma." @default.
- W4297496688 created "2022-09-29" @default.
- W4297496688 creator A5008072822 @default.
- W4297496688 creator A5033411069 @default.
- W4297496688 creator A5055861378 @default.
- W4297496688 creator A5067169649 @default.
- W4297496688 creator A5068720992 @default.
- W4297496688 creator A5070023882 @default.
- W4297496688 date "2022-09-28" @default.
- W4297496688 modified "2023-10-16" @default.
- W4297496688 title "Potential biomarkers and immune characteristics of small bowel adenocarcinoma" @default.
- W4297496688 cites W1471130860 @default.
- W4297496688 cites W1594306308 @default.
- W4297496688 cites W1946244962 @default.
- W4297496688 cites W1966327575 @default.
- W4297496688 cites W1969907849 @default.
- W4297496688 cites W1981890674 @default.
- W4297496688 cites W1982016639 @default.
- W4297496688 cites W1986387333 @default.
- W4297496688 cites W1991364339 @default.
- W4297496688 cites W1995612576 @default.
- W4297496688 cites W1999355517 @default.
- W4297496688 cites W2018045523 @default.
- W4297496688 cites W2030841613 @default.
- W4297496688 cites W2037468852 @default.
- W4297496688 cites W2040236626 @default.
- W4297496688 cites W2042209114 @default.
- W4297496688 cites W2043885338 @default.
- W4297496688 cites W2055436838 @default.
- W4297496688 cites W2057015734 @default.
- W4297496688 cites W2057322086 @default.
- W4297496688 cites W2088899354 @default.
- W4297496688 cites W2096173332 @default.
- W4297496688 cites W2096839583 @default.
- W4297496688 cites W2103912979 @default.
- W4297496688 cites W2117990720 @default.
- W4297496688 cites W2119684825 @default.
- W4297496688 cites W2124264736 @default.
- W4297496688 cites W2131085679 @default.
- W4297496688 cites W2134629862 @default.
- W4297496688 cites W2145126338 @default.
- W4297496688 cites W2145469603 @default.
- W4297496688 cites W2146512944 @default.
- W4297496688 cites W2148821594 @default.
- W4297496688 cites W2153234291 @default.
- W4297496688 cites W2155227852 @default.
- W4297496688 cites W2158217645 @default.
- W4297496688 cites W2159675211 @default.
- W4297496688 cites W2159986837 @default.
- W4297496688 cites W2170989872 @default.
- W4297496688 cites W2280845138 @default.
- W4297496688 cites W2302353269 @default.
- W4297496688 cites W2319281231 @default.
- W4297496688 cites W2341128841 @default.
- W4297496688 cites W2345356016 @default.
- W4297496688 cites W2437183361 @default.
- W4297496688 cites W2566802298 @default.
- W4297496688 cites W2580353800 @default.
- W4297496688 cites W2606004439 @default.
- W4297496688 cites W2625048728 @default.
- W4297496688 cites W2725421867 @default.
- W4297496688 cites W2746394609 @default.
- W4297496688 cites W2767546566 @default.
- W4297496688 cites W2769473760 @default.
- W4297496688 cites W2791209543 @default.
- W4297496688 cites W2923047521 @default.
- W4297496688 cites W2945047808 @default.
- W4297496688 cites W2952005535 @default.
- W4297496688 cites W2956156682 @default.
- W4297496688 cites W2969705573 @default.
- W4297496688 cites W2970644901 @default.
- W4297496688 cites W2999134910 @default.
- W4297496688 cites W3019200929 @default.
- W4297496688 cites W3027028023 @default.
- W4297496688 cites W3031699448 @default.
- W4297496688 cites W3033046864 @default.
- W4297496688 cites W3034178771 @default.
- W4297496688 cites W3042701674 @default.
- W4297496688 cites W3084640077 @default.
- W4297496688 cites W3119005666 @default.
- W4297496688 cites W3134456260 @default.
- W4297496688 cites W3162910911 @default.
- W4297496688 cites W332390835 @default.
- W4297496688 cites W4210247828 @default.
- W4297496688 cites W4213021761 @default.
- W4297496688 cites W4214867596 @default.
- W4297496688 cites W4236509122 @default.
- W4297496688 doi "https://doi.org/10.1038/s41598-022-20599-5" @default.
- W4297496688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36171259" @default.
- W4297496688 hasPublicationYear "2022" @default.
- W4297496688 type Work @default.
- W4297496688 citedByCount "4" @default.
- W4297496688 countsByYear W42974966882023 @default.
- W4297496688 crossrefType "journal-article" @default.
- W4297496688 hasAuthorship W4297496688A5008072822 @default.
- W4297496688 hasAuthorship W4297496688A5033411069 @default.
- W4297496688 hasAuthorship W4297496688A5055861378 @default.
- W4297496688 hasAuthorship W4297496688A5067169649 @default.
- W4297496688 hasAuthorship W4297496688A5068720992 @default.
- W4297496688 hasAuthorship W4297496688A5070023882 @default.