Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297498082> ?p ?o ?g. }
- W4297498082 abstract "Abstract Given the complex nature of ulcerative colitis, combination therapy targeting multiple pathogenic genes and pathways of ulcerative colitis may be required. Unfortunately, current therapeutic strategies are usually based on independent chemical compounds or monoclonal antibodies, and the full potential of combination therapy has not yet been realized for the treatment of ulcerative colitis. Here, we develop a synthetic biology strategy that integrates the naturally existing circulating system of small extracellular vesicles with artificial genetic circuits to reprogram the liver of male mice to self-assemble multiple siRNAs into secretory small extracellular vesicles and facilitate in vivo delivery siRNAs through circulating small extracellular vesicles for the combination therapy of mouse models of ulcerative colitis. Particularly, repeated injection of the multi-targeted genetic circuit designed for simultaneous inhibition of TNF-α, B7-1 and integrin α4 rapidly relieves intestinal inflammation and exerts a synergistic therapeutic effect against ulcerative colitis through suppressing the pro-inflammatory cascade in colonic macrophages, inhibiting the costimulatory signal to T cells and blocking T cell homing to sites of inflammation. More importantly, we design an AAV-driven genetic circuit to induce substantial and lasting inhibition of TNF-α, B7-1 and integrin α4 through only a single injection. Overall, this study establishes a feasible combination therapeutic strategy for ulcerative colitis, which may offer an alternative to conventional biological therapies requiring two or more independent compounds or antibodies." @default.
- W4297498082 created "2022-09-29" @default.
- W4297498082 creator A5001976663 @default.
- W4297498082 creator A5002793170 @default.
- W4297498082 creator A5019902631 @default.
- W4297498082 creator A5022677955 @default.
- W4297498082 creator A5029851973 @default.
- W4297498082 creator A5033289523 @default.
- W4297498082 creator A5035183903 @default.
- W4297498082 creator A5035700332 @default.
- W4297498082 creator A5038415873 @default.
- W4297498082 creator A5069081079 @default.
- W4297498082 creator A5078445909 @default.
- W4297498082 date "2022-09-28" @default.
- W4297498082 modified "2023-10-18" @default.
- W4297498082 title "In vivo self-assembled siRNA as a modality for combination therapy of ulcerative colitis" @default.
- W4297498082 cites W1622884606 @default.
- W4297498082 cites W1970179252 @default.
- W4297498082 cites W1973123086 @default.
- W4297498082 cites W1973359170 @default.
- W4297498082 cites W1980018183 @default.
- W4297498082 cites W1985308079 @default.
- W4297498082 cites W1985970628 @default.
- W4297498082 cites W1990597414 @default.
- W4297498082 cites W1990687490 @default.
- W4297498082 cites W2004176121 @default.
- W4297498082 cites W2008118006 @default.
- W4297498082 cites W2008161734 @default.
- W4297498082 cites W2008289270 @default.
- W4297498082 cites W2009332710 @default.
- W4297498082 cites W2011749939 @default.
- W4297498082 cites W2017857120 @default.
- W4297498082 cites W2024346860 @default.
- W4297498082 cites W2031352506 @default.
- W4297498082 cites W2032435016 @default.
- W4297498082 cites W2032735323 @default.
- W4297498082 cites W2036500213 @default.
- W4297498082 cites W2040237389 @default.
- W4297498082 cites W2052476019 @default.
- W4297498082 cites W2061437791 @default.
- W4297498082 cites W2063731747 @default.
- W4297498082 cites W2064485014 @default.
- W4297498082 cites W2087017620 @default.
- W4297498082 cites W2087559826 @default.
- W4297498082 cites W2090049175 @default.
- W4297498082 cites W2101230909 @default.
- W4297498082 cites W2103747137 @default.
- W4297498082 cites W2112340015 @default.
- W4297498082 cites W2126154166 @default.
- W4297498082 cites W2127517948 @default.
- W4297498082 cites W2131261387 @default.
- W4297498082 cites W2132784721 @default.
- W4297498082 cites W2145914167 @default.
- W4297498082 cites W2153438195 @default.
- W4297498082 cites W2154824668 @default.
- W4297498082 cites W2165655699 @default.
- W4297498082 cites W2167604259 @default.
- W4297498082 cites W2171297959 @default.
- W4297498082 cites W2418481118 @default.
- W4297498082 cites W2420040209 @default.
- W4297498082 cites W2504808189 @default.
- W4297498082 cites W2515435336 @default.
- W4297498082 cites W2583464358 @default.
- W4297498082 cites W2586889461 @default.
- W4297498082 cites W2587850954 @default.
- W4297498082 cites W2600452401 @default.
- W4297498082 cites W2608319246 @default.
- W4297498082 cites W2615184173 @default.
- W4297498082 cites W2620756707 @default.
- W4297498082 cites W2740873010 @default.
- W4297498082 cites W2750610314 @default.
- W4297498082 cites W2758187157 @default.
- W4297498082 cites W2786514708 @default.
- W4297498082 cites W2789720473 @default.
- W4297498082 cites W2809066705 @default.
- W4297498082 cites W2900276526 @default.
- W4297498082 cites W2906727442 @default.
- W4297498082 cites W2913212173 @default.
- W4297498082 cites W2933304441 @default.
- W4297498082 cites W2969587497 @default.
- W4297498082 cites W2981591470 @default.
- W4297498082 cites W3005104290 @default.
- W4297498082 cites W3018603329 @default.
- W4297498082 cites W3023952813 @default.
- W4297498082 cites W3087580838 @default.
- W4297498082 cites W3150842678 @default.
- W4297498082 cites W3175628958 @default.
- W4297498082 cites W3195101435 @default.
- W4297498082 cites W4200370252 @default.
- W4297498082 cites W4211138554 @default.
- W4297498082 cites W4229808289 @default.
- W4297498082 cites W4250089957 @default.
- W4297498082 cites W4251995081 @default.
- W4297498082 cites W4293777482 @default.
- W4297498082 doi "https://doi.org/10.1038/s41467-022-33436-0" @default.
- W4297498082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36171212" @default.
- W4297498082 hasPublicationYear "2022" @default.
- W4297498082 type Work @default.
- W4297498082 citedByCount "5" @default.
- W4297498082 countsByYear W42974980822023 @default.