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- W4297516468 abstract "Abstract Circulating tumor DNA detection using Next-Generation Sequencing (NGS) data of plasma DNA is promising for cancer identification and characterization. However, the tumor signal in the blood is often low and difficult to distinguish from errors. We present DREAMS ( D eep Rea d-level M odelling of S equencing-errors) for estimating error rates of individual read positions. Using DREAMS, we developed statistical methods for variant calling (DREAMS- vc ) and cancer detection (DREAMS- cc ). For evaluation, we generated deep targeted NGS data of matching tumor and plasma DNA from 85 colorectal cancer patients. The DREAMS approach performed better than state-of-the-art methods for variant calling and cancer detection." @default.
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- W4297516468 date "2022-09-28" @default.
- W4297516468 modified "2023-09-27" @default.
- W4297516468 title "DREAMS: Deep Read-level Error Model for Sequencing data applied to low-frequency variant calling and circulating tumor DNA detection" @default.
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- W4297516468 doi "https://doi.org/10.1101/2022.09.27.509150" @default.
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