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• W4297516845 abstract "Abstract Background There is currently no clear consensus on screening techniques to evaluate the presence or severity of Fontan-associated liver disease (FALD). Cardiac MRI (CMR) is used routinely for post-Fontan surveillance, but CMR-derived measures that relate to the severity of FALD are not yet defined. Methods This was a cross-sectional single-center study of post-Fontan patients who underwent a CMR. CMR exams were re-analyzed by a single pediatric cardiologist. Surrogates of FALD included Gamma-Glutamyl Transferase (GGT), Fibrosis-4 laboratory score (FIB-4), and imaging findings. Findings consistent with cirrhosis on liver ultrasound included increased liver echogenicity and/or nodularity. Statistical analyses were performed to investigate potential relationships between CMR parameters and markers of FALD. Results Sixty-one patients were included. A larger inferior vena cava cross-sectional area (IVC-CSA) indexed to height was significantly associated with a higher FIB-4 score (Spearman’s ρ = 0.28, P = 0.04), a higher GGT level (Spearman’s ρ = 0.40, p = 0.02), and findings consistent with cirrhosis on liver ultrasound (OR 1.17, 95% CI: (1.01, 1.35), p = 0.04). None of the other CMR parameters were associated with markers of FALD. A larger indexed IVC-CSA was associated with higher systemic ventricle end-diastolic pressure (EDP) on cardiac catheterization (Spearman’s ρ = 0.39, p = 0.018) as well as older age (Spearman’s ρ = 0.46, p = < 0.001). Conclusions Indexed IVC-CSA was the only CMR parameter that was associated with markers of FALD. This measure has the potential to serve as an additional non-invasive tool to improve screening strategies for FALD." @default.
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• W4297516845 date "2022-09-28" @default.
• W4297516845 modified "2023-09-28" @default.
• W4297516845 title "Cardiac MRI Derived Inferior Vena Cava Cross-Sectional Area Correlates with Measures of Fontan Associated Liver Disease" @default.
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• W4297516845 doi "https://doi.org/10.21203/rs.3.rs-2102272/v1" @default.
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