FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297533651> ?p ?o ?g. }

• W4297533651 endingPage "104283" @default.
• W4297533651 startingPage "104283" @default.
• W4297533651 abstract "BackgroundOpioid use disorder (OUD) is a chronic relapsing psychiatric disorder. An unconditioned stimulus (US)-triggers a memory reconsolidation updating procedure (MRUP) that has been developed and demonstrated its effectiveness in decreasing relapse to cocaine and heroin in preclinical models. However, utilizations of abused drugs as the US to initiate MRUP can be problematic. We therefore designed a translational rat study and human study to evaluate the efficacy of a novel methadone-initiated MRUP.MethodsIn the rodent study, male rats underwent heroin self-administration training for 10 consecutive days, and were randomly assigned to receive saline or methadone at 10 min, 1 h or 6 h before extinction training after 28-day withdrawal. The primary outcome was operant heroin seeking after reinstatement. In the human experimental study, male OUD patients were randomly assigned to get MRUP at 10 min or 6 h after methadone or methadone alone. The primary outcomes included experimental cue-induced heroin craving change, sustained abstinence and retention in the study at post intervention and the 5 monthly follow-up assessments. The secondary outcomes were changes in physiological responses including experimental cue-induced blood pressure and heart rate.FindingsMethadone exposure but not saline exposure at 10 min or 1 h before extinction decreased heroin-induced reinstatement of heroin seeking after 28-day of withdrawal in rats (F (8,80) = 8.26, p < 0.001). In the human study, when the MRUP was performed 10 min, but not 6 h after methadone dosing, the MRUP promoted sustained abstinence from heroin throughout 5 monthly follow-up assessments compared to giving methadone alone without MRUP (Hazard Ratio [95%CI] of 0.43 [0.22, 0.83], p = 0.01). The MRUP at 10 min, but not at 6 h after dosing also decreased experimental cue-induced heroin craving and blood pressure increases during the 6-month study duration (group × months × cue types, F (12, 63·3) = 2.41, p = 0.01).InterpretationThe approach of MRUP within about 1 to 6 h after a methadone dose potently improved several key outcomes of OUD patients during methadone maintenance treatment, and could be a potentially novel treatment to prevent opioid relapse.FundingNational Natural Science Foundation of China (NO. U1802283, 81761128036, 82001400, 82001404 and 31671143) and Chinese National Programs for Brain Science and Brain-like Intelligence Technology (NO. 2021ZD0200800)" @default.
• W4297533651 created "2022-09-29" @default.
• W4297533651 creator A5001198088 @default.
• W4297533651 creator A5001451215 @default.
• W4297533651 creator A5005240419 @default.
• W4297533651 creator A5006414413 @default.
• W4297533651 creator A5011122234 @default.
• W4297533651 creator A5019587222 @default.
• W4297533651 creator A5022593632 @default.
• W4297533651 creator A5030426436 @default.
• W4297533651 creator A5044729432 @default.
• W4297533651 creator A5057835697 @default.
• W4297533651 creator A5062209756 @default.
• W4297533651 creator A5071214414 @default.
• W4297533651 creator A5075105689 @default.
• W4297533651 creator A5076306729 @default.
• W4297533651 creator A5077179362 @default.
• W4297533651 creator A5079620519 @default.
• W4297533651 creator A5085270437 @default.
• W4297533651 creator A5085717088 @default.
• W4297533651 creator A5086445322 @default.
• W4297533651 date "2022-11-01" @default.
• W4297533651 modified "2023-10-12" @default.
• W4297533651 title "The effect of a methadone-initiated memory reconsolidation updating procedure in opioid use disorder: A translational study" @default.
• W4297533651 cites W1651861647 @default.
• W4297533651 cites W1892150242 @default.
• W4297533651 cites W1964032526 @default.
• W4297533651 cites W1970885260 @default.
• W4297533651 cites W1982125373 @default.
• W4297533651 cites W1985739085 @default.
• W4297533651 cites W2023652011 @default.
• W4297533651 cites W2045379279 @default.
• W4297533651 cites W2060160772 @default.
• W4297533651 cites W2077594514 @default.
• W4297533651 cites W2100172973 @default.
• W4297533651 cites W2107980868 @default.
• W4297533651 cites W2111198740 @default.
• W4297533651 cites W2143638847 @default.
• W4297533651 cites W2149717129 @default.
• W4297533651 cites W2169255825 @default.
• W4297533651 cites W2169803233 @default.
• W4297533651 cites W2520921948 @default.
• W4297533651 cites W2567120090 @default.
• W4297533651 cites W2583992339 @default.
• W4297533651 cites W2584977567 @default.
• W4297533651 cites W2612356851 @default.
• W4297533651 cites W2766341392 @default.
• W4297533651 cites W2891453476 @default.
• W4297533651 cites W2962781147 @default.
• W4297533651 cites W2970683278 @default.
• W4297533651 cites W3092359548 @default.
• W4297533651 cites W4200332480 @default.
• W4297533651 cites W4226063380 @default.
• W4297533651 cites W4231478450 @default.
• W4297533651 cites W867384215 @default.
• W4297533651 doi "https://doi.org/10.1016/j.ebiom.2022.104283" @default.
• W4297533651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36182773" @default.
• W4297533651 hasPublicationYear "2022" @default.
• W4297533651 type Work @default.
• W4297533651 citedByCount "2" @default.
• W4297533651 countsByYear W42975336512023 @default.
• W4297533651 crossrefType "journal-article" @default.
• W4297533651 hasAuthorship W4297533651A5001198088 @default.
• W4297533651 hasAuthorship W4297533651A5001451215 @default.
• W4297533651 hasAuthorship W4297533651A5005240419 @default.
• W4297533651 hasAuthorship W4297533651A5006414413 @default.
• W4297533651 hasAuthorship W4297533651A5011122234 @default.
• W4297533651 hasAuthorship W4297533651A5019587222 @default.
• W4297533651 hasAuthorship W4297533651A5022593632 @default.
• W4297533651 hasAuthorship W4297533651A5030426436 @default.
• W4297533651 hasAuthorship W4297533651A5044729432 @default.
• W4297533651 hasAuthorship W4297533651A5057835697 @default.
• W4297533651 hasAuthorship W4297533651A5062209756 @default.
• W4297533651 hasAuthorship W4297533651A5071214414 @default.
• W4297533651 hasAuthorship W4297533651A5075105689 @default.
• W4297533651 hasAuthorship W4297533651A5076306729 @default.
• W4297533651 hasAuthorship W4297533651A5077179362 @default.
• W4297533651 hasAuthorship W4297533651A5079620519 @default.
• W4297533651 hasAuthorship W4297533651A5085270437 @default.
• W4297533651 hasAuthorship W4297533651A5085717088 @default.
• W4297533651 hasAuthorship W4297533651A5086445322 @default.
• W4297533651 hasBestOaLocation W42975336511 @default.
• W4297533651 hasConcept C101991246 @default.
• W4297533651 hasConcept C118552586 @default.
• W4297533651 hasConcept C126322002 @default.
• W4297533651 hasConcept C151730666 @default.
• W4297533651 hasConcept C15744967 @default.
• W4297533651 hasConcept C170493617 @default.
• W4297533651 hasConcept C2777288759 @default.
• W4297533651 hasConcept C2777397205 @default.
• W4297533651 hasConcept C2778555786 @default.
• W4297533651 hasConcept C2778767360 @default.
• W4297533651 hasConcept C2778903061 @default.
• W4297533651 hasConcept C2778903686 @default.
• W4297533651 hasConcept C2779418921 @default.
• W4297533651 hasConcept C2779541405 @default.
• W4297533651 hasConcept C2780035454 @default.
• W4297533651 hasConcept C2780687700 @default.

• next