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- W4297539712 abstract "Treatment-resistant schizophrenia (TRS) is an important and unresolved problem in biological and clinical psychiatry. Approximately 30% of cases of schizophrenia (Sch) are TRS, which may be due to the fact that some patients with TRS may suffer from pathogenetically non-dopamine Sch, in the development of which neuroinflammation is supposed to play an important role. The purpose of this narrative review is an attempt to summarize the data characterizing the patterns of production of pro-inflammatory and anti-inflammatory cytokines during the development of therapeutic resistance to APs and their pathogenetic and prognostic significance of cytokine imbalance as TRS biomarkers. This narrative review demonstrates that the problem of evaluating the contribution of pro-inflammatory and anti-inflammatory cytokines to maintaining or changing the cytokine balance can become a new key in unlocking the mystery of non-dopamine Sch and developing new therapeutic strategies for the treatment of TRS and psychosis in the setting of acute and chronic neuroinflammation. In addition, the inconsistency of the results of previous studies on the role of pro-inflammatory and anti-inflammatory cytokines indicates that the TRS biomarker, most likely, is not the serum level of one or more cytokines, but the cytokine balance. We have confirmed the hypothesis that cytokine imbalance is one of the most important TRS biomarkers. This hypothesis is partially supported by the variable response to immunomodulators in patients with TRS, which were prescribed without taking into account the cytokine balance of the relation between serum levels of the most important pro-inflammatory and anti-inflammatory cytokines for TRS." @default.
- W4297539712 created "2022-09-29" @default.
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- W4297539712 date "2022-09-26" @default.
- W4297539712 modified "2023-10-12" @default.
- W4297539712 title "Cytokine Imbalance as a Biomarker of Treatment-Resistant Schizophrenia" @default.
- W4297539712 cites W1639640383 @default.
- W4297539712 cites W1963479676 @default.
- W4297539712 cites W1975042923 @default.
- W4297539712 cites W1979240455 @default.
- W4297539712 cites W2029754105 @default.
- W4297539712 cites W2035477056 @default.
- W4297539712 cites W2035859458 @default.
- W4297539712 cites W2036194983 @default.
- W4297539712 cites W2042755650 @default.
- W4297539712 cites W2045493616 @default.
- W4297539712 cites W2050463389 @default.
- W4297539712 cites W2063361808 @default.
- W4297539712 cites W2071475389 @default.
- W4297539712 cites W2072146393 @default.
- W4297539712 cites W2080339547 @default.
- W4297539712 cites W2082000302 @default.
- W4297539712 cites W2082535880 @default.
- W4297539712 cites W2101226830 @default.
- W4297539712 cites W2113251205 @default.
- W4297539712 cites W2116449427 @default.
- W4297539712 cites W2119971225 @default.
- W4297539712 cites W2120079964 @default.
- W4297539712 cites W2127064468 @default.
- W4297539712 cites W2132748057 @default.
- W4297539712 cites W2133541253 @default.
- W4297539712 cites W2149288810 @default.
- W4297539712 cites W2157369969 @default.
- W4297539712 cites W2169079754 @default.
- W4297539712 cites W2171149822 @default.
- W4297539712 cites W2210219816 @default.
- W4297539712 cites W2215158374 @default.
- W4297539712 cites W2286207305 @default.
- W4297539712 cites W2315601431 @default.
- W4297539712 cites W2399060753 @default.
- W4297539712 cites W2461671056 @default.
- W4297539712 cites W2520656017 @default.
- W4297539712 cites W2533216010 @default.
- W4297539712 cites W2557675632 @default.
- W4297539712 cites W2560668196 @default.
- W4297539712 cites W2560754155 @default.
- W4297539712 cites W2571503386 @default.
- W4297539712 cites W2594608863 @default.
- W4297539712 cites W2595474555 @default.
- W4297539712 cites W2606423725 @default.
- W4297539712 cites W2619899589 @default.
- W4297539712 cites W2757858730 @default.
- W4297539712 cites W2764269715 @default.
- W4297539712 cites W2765141817 @default.
- W4297539712 cites W2765264947 @default.
- W4297539712 cites W2766082103 @default.
- W4297539712 cites W2766457141 @default.
- W4297539712 cites W2777753808 @default.
- W4297539712 cites W2781447571 @default.
- W4297539712 cites W2787334626 @default.
- W4297539712 cites W2793585472 @default.
- W4297539712 cites W2802824384 @default.
- W4297539712 cites W2808075767 @default.
- W4297539712 cites W2883107930 @default.
- W4297539712 cites W2883285706 @default.
- W4297539712 cites W2885738092 @default.
- W4297539712 cites W2885929360 @default.
- W4297539712 cites W2888647009 @default.
- W4297539712 cites W2889106553 @default.
- W4297539712 cites W2890821010 @default.
- W4297539712 cites W2894955961 @default.
- W4297539712 cites W2901892312 @default.
- W4297539712 cites W2902611913 @default.
- W4297539712 cites W2902847649 @default.
- W4297539712 cites W2905939579 @default.
- W4297539712 cites W2909658493 @default.
- W4297539712 cites W2913362810 @default.
- W4297539712 cites W2914873709 @default.
- W4297539712 cites W2915832920 @default.
- W4297539712 cites W2918793347 @default.
- W4297539712 cites W2921960509 @default.
- W4297539712 cites W2923483102 @default.
- W4297539712 cites W2933448082 @default.
- W4297539712 cites W2939625028 @default.
- W4297539712 cites W2944331050 @default.
- W4297539712 cites W2946933805 @default.
- W4297539712 cites W2958779309 @default.
- W4297539712 cites W2964622385 @default.
- W4297539712 cites W2966662913 @default.