FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297540329> ?p ?o ?g. }

• W4297540329 abstract "Cryptotanshinone (CT), a natural compound derived from Salvia miltiorrhiza Bunge that is also known as the traditional Chinese medicine Danshen, exhibits antitumor activity in various cancers. However, it remains unclear whether CT has a potential therapeutic benefit against ovarian cancers. The aim of this study was to test the efficacy of CT in ovarian cancer cells in vitro and using a xenograft model in NSG mice orthotopically implanted with HEY A8 human ovarian cancer cells and to explore the molecular mechanism(s) underlying CT’s antitumor effects. We found that CT inhibited the proliferation, migration, and invasion of OVCAR3 and HEY A8 cells, while sensitizing the cell responses to the chemotherapy drugs paclitaxel and cisplatin. CT also suppressed ovarian tumor growth and metastasis in immunocompromised mice orthotopically inoculated with HEY A8 cells. Mechanistically, CT degraded the protein encoded by the oncogene c-Myc by promoting its ubiquitination and disrupting the interaction with its partner protein Max. CT also attenuated signaling via the nuclear focal adhesion kinase (FAK) pathway and degraded FAK protein in both cell lines. Knockdown of c-Myc using lentiviral CRISPR/Cas9 nickase resulted in reduction of FAK expression, which phenocopies the effects of CT and the c-Myc/Max inhibitor 10058-F4. Taken together, our studies demonstrate that CT inhibits primary ovarian tumor growth and metastasis by degrading c-Myc and FAK and attenuating the FAK signaling pathway." @default.
• W4297540329 created "2022-09-29" @default.
• W4297540329 creator A5000432967 @default.
• W4297540329 creator A5007473902 @default.
• W4297540329 creator A5016604916 @default.
• W4297540329 creator A5024774099 @default.
• W4297540329 creator A5031096137 @default.
• W4297540329 creator A5036752654 @default.
• W4297540329 creator A5055875257 @default.
• W4297540329 creator A5057874628 @default.
• W4297540329 creator A5063245694 @default.
• W4297540329 creator A5065485631 @default.
• W4297540329 creator A5072994598 @default.
• W4297540329 creator A5082198449 @default.
• W4297540329 date "2022-09-28" @default.
• W4297540329 modified "2023-10-16" @default.
• W4297540329 title "Cryptotanshinone inhibits ovarian tumor growth and metastasis by degrading c-Myc and attenuating the FAK signaling pathway" @default.
• W4297540329 cites W1116726549 @default.
• W4297540329 cites W1955689398 @default.
• W4297540329 cites W1979641354 @default.
• W4297540329 cites W2011133384 @default.
• W4297540329 cites W2022205031 @default.
• W4297540329 cites W2024037712 @default.
• W4297540329 cites W2044423100 @default.
• W4297540329 cites W2104538433 @default.
• W4297540329 cites W2104828754 @default.
• W4297540329 cites W2114380849 @default.
• W4297540329 cites W2120930686 @default.
• W4297540329 cites W2283420536 @default.
• W4297540329 cites W2289975095 @default.
• W4297540329 cites W2298294785 @default.
• W4297540329 cites W2335098315 @default.
• W4297540329 cites W2603128961 @default.
• W4297540329 cites W2605856867 @default.
• W4297540329 cites W2609435824 @default.
• W4297540329 cites W2625336001 @default.
• W4297540329 cites W2626027566 @default.
• W4297540329 cites W2767139158 @default.
• W4297540329 cites W2792084754 @default.
• W4297540329 cites W2801965936 @default.
• W4297540329 cites W2804613528 @default.
• W4297540329 cites W2884110043 @default.
• W4297540329 cites W2887528920 @default.
• W4297540329 cites W2888098447 @default.
• W4297540329 cites W2891693347 @default.
• W4297540329 cites W2901306165 @default.
• W4297540329 cites W2901669535 @default.
• W4297540329 cites W2907102050 @default.
• W4297540329 cites W2910236521 @default.
• W4297540329 cites W2938524649 @default.
• W4297540329 cites W2966445105 @default.
• W4297540329 cites W2972861119 @default.
• W4297540329 cites W2990664312 @default.
• W4297540329 cites W3010470146 @default.
• W4297540329 cites W3011990562 @default.
• W4297540329 cites W3020074246 @default.
• W4297540329 cites W4224982817 @default.
• W4297540329 doi "https://doi.org/10.3389/fcell.2022.959518" @default.
• W4297540329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36247016" @default.
• W4297540329 hasPublicationYear "2022" @default.
• W4297540329 type Work @default.
• W4297540329 citedByCount "1" @default.
• W4297540329 countsByYear W42975403292023 @default.
• W4297540329 crossrefType "journal-article" @default.
• W4297540329 hasAuthorship W4297540329A5000432967 @default.
• W4297540329 hasAuthorship W4297540329A5007473902 @default.
• W4297540329 hasAuthorship W4297540329A5016604916 @default.
• W4297540329 hasAuthorship W4297540329A5024774099 @default.
• W4297540329 hasAuthorship W4297540329A5031096137 @default.
• W4297540329 hasAuthorship W4297540329A5036752654 @default.
• W4297540329 hasAuthorship W4297540329A5055875257 @default.
• W4297540329 hasAuthorship W4297540329A5057874628 @default.
• W4297540329 hasAuthorship W4297540329A5063245694 @default.
• W4297540329 hasAuthorship W4297540329A5065485631 @default.
• W4297540329 hasAuthorship W4297540329A5072994598 @default.
• W4297540329 hasAuthorship W4297540329A5082198449 @default.
• W4297540329 hasBestOaLocation W42975403291 @default.
• W4297540329 hasConcept C121608353 @default.
• W4297540329 hasConcept C126322002 @default.
• W4297540329 hasConcept C142724271 @default.
• W4297540329 hasConcept C151166631 @default.
• W4297540329 hasConcept C173396325 @default.
• W4297540329 hasConcept C185592680 @default.
• W4297540329 hasConcept C188947578 @default.
• W4297540329 hasConcept C204787440 @default.
• W4297540329 hasConcept C2776332195 @default.
• W4297540329 hasConcept C2777292972 @default.
• W4297540329 hasConcept C2779013556 @default.
• W4297540329 hasConcept C2780427987 @default.
• W4297540329 hasConcept C2781018059 @default.
• W4297540329 hasConcept C29537977 @default.
• W4297540329 hasConcept C502942594 @default.
• W4297540329 hasConcept C54355233 @default.
• W4297540329 hasConcept C62112901 @default.
• W4297540329 hasConcept C62478195 @default.
• W4297540329 hasConcept C71924100 @default.
• W4297540329 hasConcept C81885089 @default.
• W4297540329 hasConcept C86803240 @default.
• W4297540329 hasConcept C95444343 @default.
• W4297540329 hasConceptScore W4297540329C121608353 @default.

• next