FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297546456> ?p ?o ?g. }

• W4297546456 abstract "Meningitis due to the fungal pathogen Cryptococcus neoformans is estimated to cause nearly 200,000 deaths annually, mostly in resource-limited regions. We previously identified cryptococcal protein antigens which, when delivered in glucan particles, afford vaccine-mediated protection against an otherwise lethal infection. Many of these proteins exhibit significant homology to other similar cryptococcal proteins leading us to hypothesize that protection may be augmented by immunologic cross-reactivity to multiple members of a protein family. To examine the significance of protein cross-reactivity in vaccination, we utilized strains of Cryptococcus that are genetically deficient in select antigens, yet are still lethal in mice. Vaccination with a protein without homologs (e.g., Mep1 and Lhc1) protected against challenge with wild-type Cryptococcus , but not against a deletion strain lacking that protein. Contrastingly, vaccination with a single chitin deacetylase (Cda) protein protected against the corresponding deletion strain, presumably due to host recognition of one or more other family members still expressed in this strain. Vaccination with a single Cda protein induced cross-reactive antibody and interferon-gamma (IFNγ) immune responses to other Cda protein family members. Paradoxically, we saw no evidence of cross-protection within the carboxypeptidase family of proteins. Factors such as in vivo protein expression and the degree of homology across the family could inform the extent to which vaccine-mediated immunity is amplified. Together, these data suggest a role for prioritizing protein families in fungal vaccine design: increasing the number of immune targets generated by a single antigen may improve efficacy while diminishing the risk of vaccine-resistant strains arising from gene mutations." @default.
• W4297546456 created "2022-09-29" @default.
• W4297546456 creator A5044668670 @default.
• W4297546456 creator A5045642913 @default.
• W4297546456 creator A5054141043 @default.
• W4297546456 creator A5056742280 @default.
• W4297546456 creator A5061159041 @default.
• W4297546456 creator A5065799573 @default.
• W4297546456 creator A5081023775 @default.
• W4297546456 creator A5082676196 @default.
• W4297546456 date "2022-09-28" @default.
• W4297546456 modified "2023-10-18" @default.
• W4297546456 title "Cross-reactivity between vaccine antigens from the chitin deacetylase protein family improves survival in a mouse model of cryptococcosis" @default.
• W4297546456 cites W1923209545 @default.
• W4297546456 cites W1935097178 @default.
• W4297546456 cites W1994282287 @default.
• W4297546456 cites W2005361432 @default.
• W4297546456 cites W2006091616 @default.
• W4297546456 cites W2020541351 @default.
• W4297546456 cites W2031561912 @default.
• W4297546456 cites W2054253853 @default.
• W4297546456 cites W2055043387 @default.
• W4297546456 cites W2079401244 @default.
• W4297546456 cites W2080537082 @default.
• W4297546456 cites W2082120419 @default.
• W4297546456 cites W2097554202 @default.
• W4297546456 cites W2108576174 @default.
• W4297546456 cites W2111082083 @default.
• W4297546456 cites W2112005645 @default.
• W4297546456 cites W2123941872 @default.
• W4297546456 cites W2132926880 @default.
• W4297546456 cites W2138465665 @default.
• W4297546456 cites W2192071399 @default.
• W4297546456 cites W2219979778 @default.
• W4297546456 cites W2357298441 @default.
• W4297546456 cites W2611697423 @default.
• W4297546456 cites W2766903030 @default.
• W4297546456 cites W2768674794 @default.
• W4297546456 cites W2768821520 @default.
• W4297546456 cites W2770616161 @default.
• W4297546456 cites W2784422635 @default.
• W4297546456 cites W2801445501 @default.
• W4297546456 cites W2899440123 @default.
• W4297546456 cites W2963979690 @default.
• W4297546456 cites W2968154944 @default.
• W4297546456 cites W2985361774 @default.
• W4297546456 cites W2990051085 @default.
• W4297546456 cites W2990975336 @default.
• W4297546456 cites W2995375854 @default.
• W4297546456 cites W3003251053 @default.
• W4297546456 cites W3005109537 @default.
• W4297546456 cites W3044266761 @default.
• W4297546456 cites W3134624653 @default.
• W4297546456 cites W4220985215 @default.
• W4297546456 cites W4225832450 @default.
• W4297546456 doi "https://doi.org/10.3389/fimmu.2022.1015586" @default.
• W4297546456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36248898" @default.
• W4297546456 hasPublicationYear "2022" @default.
• W4297546456 type Work @default.
• W4297546456 citedByCount "2" @default.
• W4297546456 countsByYear W42975464562023 @default.
• W4297546456 crossrefType "journal-article" @default.
• W4297546456 hasAuthorship W4297546456A5044668670 @default.
• W4297546456 hasAuthorship W4297546456A5045642913 @default.
• W4297546456 hasAuthorship W4297546456A5054141043 @default.
• W4297546456 hasAuthorship W4297546456A5056742280 @default.
• W4297546456 hasAuthorship W4297546456A5061159041 @default.
• W4297546456 hasAuthorship W4297546456A5065799573 @default.
• W4297546456 hasAuthorship W4297546456A5081023775 @default.
• W4297546456 hasAuthorship W4297546456A5082676196 @default.
• W4297546456 hasBestOaLocation W42975464561 @default.
• W4297546456 hasConcept C147483822 @default.
• W4297546456 hasConcept C159047783 @default.
• W4297546456 hasConcept C203014093 @default.
• W4297546456 hasConcept C22070199 @default.
• W4297546456 hasConcept C2777893358 @default.
• W4297546456 hasConcept C2778952914 @default.
• W4297546456 hasConcept C2779413141 @default.
• W4297546456 hasConcept C86803240 @default.
• W4297546456 hasConcept C8891405 @default.
• W4297546456 hasConcept C89423630 @default.
• W4297546456 hasConceptScore W4297546456C147483822 @default.
• W4297546456 hasConceptScore W4297546456C159047783 @default.
• W4297546456 hasConceptScore W4297546456C203014093 @default.
• W4297546456 hasConceptScore W4297546456C22070199 @default.
• W4297546456 hasConceptScore W4297546456C2777893358 @default.
• W4297546456 hasConceptScore W4297546456C2778952914 @default.
• W4297546456 hasConceptScore W4297546456C2779413141 @default.
• W4297546456 hasConceptScore W4297546456C86803240 @default.
• W4297546456 hasConceptScore W4297546456C8891405 @default.
• W4297546456 hasConceptScore W4297546456C89423630 @default.
• W4297546456 hasFunder F4320337355 @default.
• W4297546456 hasLocation W42975464561 @default.
• W4297546456 hasLocation W42975464562 @default.
• W4297546456 hasLocation W42975464563 @default.
• W4297546456 hasOpenAccess W4297546456 @default.
• W4297546456 hasPrimaryLocation W42975464561 @default.
• W4297546456 hasRelatedWork W1817460788 @default.
• W4297546456 hasRelatedWork W1959967360 @default.
• W4297546456 hasRelatedWork W2114534320 @default.

• next