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- W4297683549 abstract "Newborns and infants have distinct and developing respiratory, hematologic, cardiovascular, renal, and central nervous system physiologies. This directly influences developmental pharmacology as well as pharmacokinetics and pharmacodynamics of anesthetics. In anesthetized infants, respiratory system anatomy leads to differences in respiratory function, functional residual capacity (FRC), tidal volume, and other ventilatory functions. Cellular and structural changes in the heart also impact cardiac output, compliance of the left ventricle, and blood pressure ranges. Systemic blood pressure plays a role in autoregulation of cerebral blood flow (CBF), which is coupled to the cerebral metabolic rate of oxygen consumption (CMRO2) in children. Additionally, a lower glomerular filtration rate (GFR) and tubular function in newborns can be of significance during events such as intraoperative evaporative fluid losses. Keeping these physiologic differences in mind, anesthesiologists primarily focus on rates and amounts of IV and inhaled anesthetics that reach an effect site and leave an effect site. These pharmacokinetic processes are regulated by the drug’s volume of distribution, distribution clearance, protein binding, and elimination clearance." @default.
- W4297683549 created "2022-09-30" @default.
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- W4297683549 date "2022-01-01" @default.
- W4297683549 modified "2023-09-26" @default.
- W4297683549 title "Developmental Physiology and Pharmacology" @default.
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- W4297683549 doi "https://doi.org/10.1016/b978-0-323-82902-1.00002-0" @default.
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