Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297703465> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4297703465 abstract "In small sample studies with binary outcome data, use of a normal approximation for hypothesis testing can lead to substantial inflation of the type-I error-rate. Consequently, exact statistical methods are necessitated, and accordingly, much research has been conducted to facilitate this. Recently, this has included methodology for the design of two-stage multi-arm studies utilising exact binomial tests. These designs were demonstrated to carry substantial efficiency advantages over a fixed sample design, but generally suffered from strong conservatism. An alternative classical means of small sample inference with dichotomous data is Fisher's exact test. However, this method is limited to single-stage designs when there are multiple arms. Therefore, here, we propose a two-stage version of Fisher's exact test, with the potential to stop early to accept or reject null hypotheses, which is applicable to multi-arm studies. In particular, we provide precise formulae describing the requirements for achieving weak or strong control of the familywise error-rate with this design. Following this, we describe how the design parameters may be optimised to confer desirable operating characteristics. For a motivating example based on a phase II clinical trial, we demonstrate that on average our approach is less conservative than corresponding optimal designs based on exact binomial tests." @default.
- W4297703465 created "2022-09-30" @default.
- W4297703465 creator A5016743017 @default.
- W4297703465 creator A5038778256 @default.
- W4297703465 creator A5088889594 @default.
- W4297703465 date "2017-11-28" @default.
- W4297703465 modified "2023-09-28" @default.
- W4297703465 title "A two-stage Fisher exact test for multi-arm studies with binary outcome variables" @default.
- W4297703465 doi "https://doi.org/10.48550/arxiv.1711.10199" @default.
- W4297703465 hasPublicationYear "2017" @default.
- W4297703465 type Work @default.
- W4297703465 citedByCount "0" @default.
- W4297703465 crossrefType "posted-content" @default.
- W4297703465 hasAuthorship W4297703465A5016743017 @default.
- W4297703465 hasAuthorship W4297703465A5038778256 @default.
- W4297703465 hasAuthorship W4297703465A5088889594 @default.
- W4297703465 hasBestOaLocation W42977034651 @default.
- W4297703465 hasConcept C100906024 @default.
- W4297703465 hasConcept C105795698 @default.
- W4297703465 hasConcept C129848803 @default.
- W4297703465 hasConcept C144237770 @default.
- W4297703465 hasConcept C148220186 @default.
- W4297703465 hasConcept C148444598 @default.
- W4297703465 hasConcept C154606282 @default.
- W4297703465 hasConcept C154945302 @default.
- W4297703465 hasConcept C183905921 @default.
- W4297703465 hasConcept C191093355 @default.
- W4297703465 hasConcept C191988596 @default.
- W4297703465 hasConcept C199335787 @default.
- W4297703465 hasConcept C2776214188 @default.
- W4297703465 hasConcept C2781315470 @default.
- W4297703465 hasConcept C33923547 @default.
- W4297703465 hasConcept C40696583 @default.
- W4297703465 hasConcept C41008148 @default.
- W4297703465 hasConcept C41054675 @default.
- W4297703465 hasConcept C44249647 @default.
- W4297703465 hasConcept C48372109 @default.
- W4297703465 hasConcept C6239989 @default.
- W4297703465 hasConcept C87007009 @default.
- W4297703465 hasConcept C94375191 @default.
- W4297703465 hasConceptScore W4297703465C100906024 @default.
- W4297703465 hasConceptScore W4297703465C105795698 @default.
- W4297703465 hasConceptScore W4297703465C129848803 @default.
- W4297703465 hasConceptScore W4297703465C144237770 @default.
- W4297703465 hasConceptScore W4297703465C148220186 @default.
- W4297703465 hasConceptScore W4297703465C148444598 @default.
- W4297703465 hasConceptScore W4297703465C154606282 @default.
- W4297703465 hasConceptScore W4297703465C154945302 @default.
- W4297703465 hasConceptScore W4297703465C183905921 @default.
- W4297703465 hasConceptScore W4297703465C191093355 @default.
- W4297703465 hasConceptScore W4297703465C191988596 @default.
- W4297703465 hasConceptScore W4297703465C199335787 @default.
- W4297703465 hasConceptScore W4297703465C2776214188 @default.
- W4297703465 hasConceptScore W4297703465C2781315470 @default.
- W4297703465 hasConceptScore W4297703465C33923547 @default.
- W4297703465 hasConceptScore W4297703465C40696583 @default.
- W4297703465 hasConceptScore W4297703465C41008148 @default.
- W4297703465 hasConceptScore W4297703465C41054675 @default.
- W4297703465 hasConceptScore W4297703465C44249647 @default.
- W4297703465 hasConceptScore W4297703465C48372109 @default.
- W4297703465 hasConceptScore W4297703465C6239989 @default.
- W4297703465 hasConceptScore W4297703465C87007009 @default.
- W4297703465 hasConceptScore W4297703465C94375191 @default.
- W4297703465 hasLocation W42977034651 @default.
- W4297703465 hasOpenAccess W4297703465 @default.
- W4297703465 hasPrimaryLocation W42977034651 @default.
- W4297703465 hasRelatedWork W1978113809 @default.
- W4297703465 hasRelatedWork W2013386908 @default.
- W4297703465 hasRelatedWork W2021153676 @default.
- W4297703465 hasRelatedWork W2047173860 @default.
- W4297703465 hasRelatedWork W2049564589 @default.
- W4297703465 hasRelatedWork W2056967931 @default.
- W4297703465 hasRelatedWork W2076971451 @default.
- W4297703465 hasRelatedWork W2768679203 @default.
- W4297703465 hasRelatedWork W3160761450 @default.
- W4297703465 hasRelatedWork W4236064109 @default.
- W4297703465 isParatext "false" @default.
- W4297703465 isRetracted "false" @default.
- W4297703465 workType "article" @default.