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- W4297777502 abstract "<sec> <title>BACKGROUND</title> Reliable and interpretable automatic extraction of clinical phenotypes from large electronic medical records databases remains a challenge, especially in a language other than English. </sec> <sec> <title>OBJECTIVE</title> We aimed to provide an automated end-to-end extraction of cohorts of similar patients from electronic health records for systemic diseases. </sec> <sec> <title>METHODS</title> Our multistep algorithm includes a named-entity recognition step, a multilabel classification using Medical Subject Headings ontology and the computation of patient similarity. A selection of cohorts of similar patients on a priori annotated phenotypes was performed. Six phenotypes were selected for their clinical significance: P1-osteoporosis, P2-nephritis in systemic erythematosus lupus, P3-interstitial lung disease in systemic sclerosis, P4-lung infection, P5-obstetric antiphospholipid syndrome, and P6-Takayasu stroke. We used a training set of 151 clinical notes and an independent validation set of 256 clinical notes, with annotated phenotypes, both extracted from the Assistance Publique-Hôpitaux de Paris data warehouse. We evaluated the precision of the 3 patients closest to the index patient for each phenotype with the precision-at-3, and the recall and average precision. </sec> <sec> <title>RESULTS</title> For P1-P4, the precision-at-3 ranged from 0.85 [0.75, 0.95] to 0.99 [0.98, 1], the recall ranged from 0.53[0.50, 0.55] to 0.83[0.81, 0.84], and the average precision ranged from 0.58 [0.54, 0.62] to 0.88 [0.85, 0.90], respectively. P5-P6 phenotypes could not be analysed due to a limited number of phenotypes. </sec> <sec> <title>CONCLUSIONS</title> Using a method close to clinical reasoning, we built a scalable and interpretable end-to-end algorithm to extract cohorts of similar patients. </sec>" @default.
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- W4297777502 date "2022-09-01" @default.
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- W4297777502 title "Construction of cohorts of similar patients from automatic extraction of medical concepts (Preprint)" @default.
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- W4297777502 doi "https://doi.org/10.2196/preprints.42379" @default.
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