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- W429778924 abstract "Agonist-stimulated hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns(4, 5) P2) is now thought to be one of the major transmembrane signalling pathways involved in pharmacomechanical coupling in airways smooth muscle (ASM) [1–3]. The enzyme which plays such a pivotal role in this process, namely phosphoinositidase C (PIC), is a phosphodiesterase of the phospholipase C type and is responsible for the cleavage of PtdIns(4, 5) P2 into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) which serve to activate protein kinase C (PKC) and release intracellular Ca2+ respectively. The early studies which began to implicate a second-messenger function for Ins(1,4, 5) P3 in ASM contraction [4–7] have fuelled much research in this area not least because they offered one of the first plausible mechanisms whereby receptor activation could be linked to the release of intracellular Ca2+ in a manner that was not dependent on changes in membrane potential. It is now clear however, that a number of other membrane associated ‘phosphodiesterase-like’ enzymes including phospholipase D and phospholipase A2 may also be involved in integrating the response of ASM cells to incoming hormonal or neurotransmitter signals." @default.
- W429778924 created "2016-06-24" @default.
- W429778924 creator A5007389587 @default.
- W429778924 date "1994-01-01" @default.
- W429778924 modified "2023-09-26" @default.
- W429778924 title "Phosphoinositidase C, Inositol Polyphosphates and Force Generation of Airways Smooth Muscle" @default.
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- W429778924 doi "https://doi.org/10.1007/978-3-0348-7681-0_4" @default.
- W429778924 hasPublicationYear "1994" @default.
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