Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297841238> ?p ?o ?g. }
- W4297841238 endingPage "868" @default.
- W4297841238 startingPage "843" @default.
- W4297841238 abstract "Epigenetic mechanisms are regulated by DNA and histone modifications, and these modifications are finely tuned by diverse molecules in a locus-specific manner. To obtain insight into these mechanisms, it is important to identify the factors involved in locus-specific epigenetic regulation, and it is also useful to artificially introduce desirable epigenetic modifications at a target locus and analyze their effect on its biological output. The recent advent of engineered DNA-binding molecules such as zinc finger proteins, transcription activator-like effector proteins, and the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein (Cas) (CRISPR/Cas) system has enabled us to specifically localize epigenetic modifiers, such as DNA methyltransferases and histone-modifying enzymes, to loci of interest. In addition, these engineered DNA-binding molecules can be used to tag specific loci to isolate them, followed by identification of interacting epigenetic modifiers. These approaches yield mechanistic insight into epigenetic pathogenesis of disorders and therapeutic applications. In this chapter, we describe applications of engineered DNA-binding molecules to epigenetic research." @default.
- W4297841238 created "2022-10-01" @default.
- W4297841238 creator A5052933407 @default.
- W4297841238 creator A5080519234 @default.
- W4297841238 date "2023-01-01" @default.
- W4297841238 modified "2023-09-23" @default.
- W4297841238 title "New Directions for Epigenetics: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research" @default.
- W4297841238 cites W1505917984 @default.
- W4297841238 cites W1555664806 @default.
- W4297841238 cites W1643500256 @default.
- W4297841238 cites W1669374546 @default.
- W4297841238 cites W1781616565 @default.
- W4297841238 cites W1907909844 @default.
- W4297841238 cites W1948462113 @default.
- W4297841238 cites W1964058953 @default.
- W4297841238 cites W1970831058 @default.
- W4297841238 cites W1973062929 @default.
- W4297841238 cites W1974008072 @default.
- W4297841238 cites W1976125136 @default.
- W4297841238 cites W1980516976 @default.
- W4297841238 cites W1980744841 @default.
- W4297841238 cites W1984189327 @default.
- W4297841238 cites W1995184879 @default.
- W4297841238 cites W1996053442 @default.
- W4297841238 cites W1996424712 @default.
- W4297841238 cites W1997509018 @default.
- W4297841238 cites W2000643204 @default.
- W4297841238 cites W2000827155 @default.
- W4297841238 cites W2000875293 @default.
- W4297841238 cites W2002402255 @default.
- W4297841238 cites W2005276705 @default.
- W4297841238 cites W2005478486 @default.
- W4297841238 cites W2009088833 @default.
- W4297841238 cites W2010232809 @default.
- W4297841238 cites W2011235782 @default.
- W4297841238 cites W2011914524 @default.
- W4297841238 cites W2016246105 @default.
- W4297841238 cites W2016991182 @default.
- W4297841238 cites W2020114768 @default.
- W4297841238 cites W2021447748 @default.
- W4297841238 cites W2023638991 @default.
- W4297841238 cites W2024962857 @default.
- W4297841238 cites W2026324263 @default.
- W4297841238 cites W2026520402 @default.
- W4297841238 cites W2028403985 @default.
- W4297841238 cites W2029484950 @default.
- W4297841238 cites W2030974598 @default.
- W4297841238 cites W2032052720 @default.
- W4297841238 cites W2033759856 @default.
- W4297841238 cites W2035420256 @default.
- W4297841238 cites W2036176224 @default.
- W4297841238 cites W2036383992 @default.
- W4297841238 cites W2038849570 @default.
- W4297841238 cites W2040605299 @default.
- W4297841238 cites W2041250686 @default.
- W4297841238 cites W2045435533 @default.
- W4297841238 cites W2045460763 @default.
- W4297841238 cites W2048768088 @default.
- W4297841238 cites W2050480410 @default.
- W4297841238 cites W2055790209 @default.
- W4297841238 cites W2058725026 @default.
- W4297841238 cites W2062186651 @default.
- W4297841238 cites W2066783444 @default.
- W4297841238 cites W2068825032 @default.
- W4297841238 cites W2070021921 @default.
- W4297841238 cites W2070614858 @default.
- W4297841238 cites W2070708756 @default.
- W4297841238 cites W2073148243 @default.
- W4297841238 cites W2074276621 @default.
- W4297841238 cites W2074540382 @default.
- W4297841238 cites W2075527287 @default.
- W4297841238 cites W2077659966 @default.
- W4297841238 cites W2085819365 @default.
- W4297841238 cites W2087616533 @default.
- W4297841238 cites W2088071434 @default.
- W4297841238 cites W2089417246 @default.
- W4297841238 cites W2089589904 @default.
- W4297841238 cites W2091657079 @default.
- W4297841238 cites W2096261947 @default.
- W4297841238 cites W2096791413 @default.
- W4297841238 cites W2097102074 @default.
- W4297841238 cites W2100203117 @default.
- W4297841238 cites W2107739540 @default.
- W4297841238 cites W2110399041 @default.
- W4297841238 cites W2110511887 @default.
- W4297841238 cites W2111460423 @default.
- W4297841238 cites W2111648798 @default.
- W4297841238 cites W2112444085 @default.
- W4297841238 cites W2115844104 @default.
- W4297841238 cites W2117819670 @default.
- W4297841238 cites W2118746294 @default.
- W4297841238 cites W2119448074 @default.
- W4297841238 cites W2121659981 @default.
- W4297841238 cites W2123502778 @default.
- W4297841238 cites W2127862779 @default.
- W4297841238 cites W2130069008 @default.
- W4297841238 cites W2131190398 @default.
- W4297841238 cites W2135832165 @default.