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• W4297846670 abstract "Abstract Background The MIR663AHG gene encode both miR663AHG and miR663a . While miR663a contributes to the defense of host cells against inflammation and inhibits colon cancer development, the biological function of lncRNA miR663AHG has not been previously reported. Methods The subcellular localization of lncRNA miR663AHG was determined by RNA-FISH. miR663AHG and miR663a were measured by qRT-PCR. The effects of miR663AHG on the growth and metastasis of colon cancer cells were investigated in vitro and in vivo . CRISPR/Cas9, RNA pulldown, and other biological assays were used to explore the underlying mechanism of miR663AHG . Results miR663AHG was mainly distributed in the nucleus of Caco2 and HCT116 cells and the cytoplasm of SW480 cells. The expression level of miR663AHG was positively correlated with the level of miR663a ( r = 0.179, P = 0.015) and significantly downregulated in colon cancer tissues relative to paired normal tissues from 119 patients ( P < 0.008). Colon cancers with low miR663AHG expression were associated with advanced pTNM stage ( P = 0.021), lymph metastasis ( P = 0.041), and shorter overall survival (hazard ratio = 2.026; P = 0.021). Experimentally, miR663AHG inhibited colon cancer cell proliferation, migration, and invasion. The growth of xenografts from RKO cells overexpressing miR663AHG was slower than that of xenografts from vector control cells in BALB/c nude mice ( P = 0.007). Interestingly, either RNA-interfering or resveratrol-inducing expression changes of miR663AHG or miR663a can trigger negative feedback regulation of transcription of the MIR663AHG gene. Mechanistically, miR663AHG could bind to miR663a and its precursor pre-miR663a , and prevent the degradation of miR663a target mRNAs. Disruption of the negative feedback by knockout of the MIR663AHG promoter, exon-1, and pri-miR663A -coding sequence entirely blocked these effects of miR663AHG . Conclusion miR663AHG functions as a tumor suppressor that inhibits the development of colon cancer through its cis -binding to miR663a/pre-miR663a. The negative feedback loop between miR663AHG and miR663a expression may play dominant roles in maintaining the functions of miR663AHG in colon cancer development." @default.
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• W4297846670 date "2022-09-08" @default.
• W4297846670 modified "2023-10-17" @default.
• W4297846670 title "LncRNA miR663AHG represses the development of colon cancer in a miR663a expression-dependent negative feedback loop" @default.
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• W4297846670 doi "https://doi.org/10.21203/rs.3.rs-1948902/v1" @default.
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