Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297853886> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4297853886 abstract "In recent years, new technologies in neuroscience have made it possible to measure the activities of large numbers of neurons simultaneously in behaving animals. For each neuron, a fluorescence trace is measured; this can be seen as a first-order approximation of the neuron's activity over time. Determining the exact time at which a neuron spikes on the basis of its fluorescence trace is an important open problem in the field of computational neuroscience. Recently, a convex optimization problem involving an $ell_1$ penalty was proposed for this task. In this paper, we slightly modify that recent proposal by replacing the $ell_1$ penalty with an $ell_0$ penalty. In stark contrast to the conventional wisdom that $ell_0$ optimization problems are computationally intractable, we show that the resulting optimization problem can be efficiently solved for the global optimum using an extremely simple and efficient dynamic programming algorithm. Our R-language implementation of the proposed algorithm runs in a few minutes on fluorescence traces of $100,000$ timesteps. Furthermore, our proposal leads to substantial improvements over the previous $ell_1$ proposal, in simulations as well as on two calcium imaging data sets. R-language software for our proposal is available on CRAN in the package LZeroSpikeInference. Instructions for running this software in python can be found at https://github.com/jewellsean/LZeroSpikeInference." @default.
- W4297853886 created "2022-10-01" @default.
- W4297853886 creator A5000338818 @default.
- W4297853886 creator A5031682567 @default.
- W4297853886 date "2017-03-24" @default.
- W4297853886 modified "2023-10-14" @default.
- W4297853886 title "Exact Spike Train Inference Via $ell_0$ Optimization" @default.
- W4297853886 doi "https://doi.org/10.48550/arxiv.1703.08644" @default.
- W4297853886 hasPublicationYear "2017" @default.
- W4297853886 type Work @default.
- W4297853886 citedByCount "0" @default.
- W4297853886 crossrefType "posted-content" @default.
- W4297853886 hasAuthorship W4297853886A5000338818 @default.
- W4297853886 hasAuthorship W4297853886A5031682567 @default.
- W4297853886 hasBestOaLocation W42978538861 @default.
- W4297853886 hasConcept C11413529 @default.
- W4297853886 hasConcept C115903868 @default.
- W4297853886 hasConcept C126255220 @default.
- W4297853886 hasConcept C137836250 @default.
- W4297853886 hasConcept C138885662 @default.
- W4297853886 hasConcept C154945302 @default.
- W4297853886 hasConcept C199360897 @default.
- W4297853886 hasConcept C2776214188 @default.
- W4297853886 hasConcept C2777904410 @default.
- W4297853886 hasConcept C2780009758 @default.
- W4297853886 hasConcept C2781390188 @default.
- W4297853886 hasConcept C33923547 @default.
- W4297853886 hasConcept C41008148 @default.
- W4297853886 hasConcept C41895202 @default.
- W4297853886 hasConcept C519991488 @default.
- W4297853886 hasConcept C75291252 @default.
- W4297853886 hasConcept C77088390 @default.
- W4297853886 hasConceptScore W4297853886C11413529 @default.
- W4297853886 hasConceptScore W4297853886C115903868 @default.
- W4297853886 hasConceptScore W4297853886C126255220 @default.
- W4297853886 hasConceptScore W4297853886C137836250 @default.
- W4297853886 hasConceptScore W4297853886C138885662 @default.
- W4297853886 hasConceptScore W4297853886C154945302 @default.
- W4297853886 hasConceptScore W4297853886C199360897 @default.
- W4297853886 hasConceptScore W4297853886C2776214188 @default.
- W4297853886 hasConceptScore W4297853886C2777904410 @default.
- W4297853886 hasConceptScore W4297853886C2780009758 @default.
- W4297853886 hasConceptScore W4297853886C2781390188 @default.
- W4297853886 hasConceptScore W4297853886C33923547 @default.
- W4297853886 hasConceptScore W4297853886C41008148 @default.
- W4297853886 hasConceptScore W4297853886C41895202 @default.
- W4297853886 hasConceptScore W4297853886C519991488 @default.
- W4297853886 hasConceptScore W4297853886C75291252 @default.
- W4297853886 hasConceptScore W4297853886C77088390 @default.
- W4297853886 hasLocation W42978538861 @default.
- W4297853886 hasLocation W42978538862 @default.
- W4297853886 hasOpenAccess W4297853886 @default.
- W4297853886 hasPrimaryLocation W42978538861 @default.
- W4297853886 hasRelatedWork W1578785168 @default.
- W4297853886 hasRelatedWork W2030465528 @default.
- W4297853886 hasRelatedWork W2072857507 @default.
- W4297853886 hasRelatedWork W2249768251 @default.
- W4297853886 hasRelatedWork W2383986235 @default.
- W4297853886 hasRelatedWork W2529681551 @default.
- W4297853886 hasRelatedWork W2780236089 @default.
- W4297853886 hasRelatedWork W2889185350 @default.
- W4297853886 hasRelatedWork W3022973810 @default.
- W4297853886 hasRelatedWork W77035938 @default.
- W4297853886 isParatext "false" @default.
- W4297853886 isRetracted "false" @default.
- W4297853886 workType "article" @default.