Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297873120> ?p ?o ?g. }
- W4297873120 endingPage "12" @default.
- W4297873120 startingPage "1" @default.
- W4297873120 abstract "Gastrodin is a main medicinal component of traditional Chinese medicine (TCM) Gastrodia elata Blume (G. elata), presenting the potential for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, the underlying targets and action mechanisms of the treatment have not been identified.The gastrodin-related microarray dataset GSE85871 was obtained from the GEO database and analyzed by GEO2R to obtain differentially expressed genes (DEGs). Subsequently, the targets of gastrodin were supplemented by the Encyclopedia of Traditional Chinese Medicine (ETCM), PubChem, STITCH, and SwissTargetPrediction databases. ADHD-associated genes were collected from six available disease databases (i.e., TTD, DrugBank, OMIM, PharmGKB, GAD, and KEGG DISEASE). The potential targets of gastrodin during ADHD treatment were obtained by mapping gastrodin-related targets with ADHD genes, and their protein-protein interaction (PPI) relationship was constructed by the STRING database. The GO function and KEGG pathway enrichment analyses were performed using the ClueGO plug-in in the Cytoscape software and DAVID database, respectively. Finally, the binding affinity between gastrodin and important targets was verified by molecular docking.A total of 460 gastrodin-related DEGs were identified from GSE85871, and 124 known gastrodin targets were supplemented from 4 databases, including ETCM. A total of 440 genes were collected from the above 6 disease databases, and 267 ADHD-relevant genes were obtained after duplicate removal. Through mapping the 584 gastrodin targets to the 267 ADHD genes, 16 potential therapeutic targets were obtained, among which the important ones were DRD2, DRD4, CHRNA3, CYP1A1, TNF, IL6, and KCNJ3. The enrichment analysis results indicated that 16 potential targets were involved in 25 biological processes (e.g., dopamine (DA) transport) and 22 molecular functions (e.g., postsynaptic neurotransmitter receptor activity), which were mainly localized at excitatory synapses. The neuroactive ligand-receptor interaction, cholinergic synapse, and dopaminergic synapse might be the core pathways of gastrodin in ADHD treatment. Through molecular docking, it was preliminarily verified that gastrodin showed good binding activity to seven important targets and formed stable binding conformations.Gastrodin might exert an anti-ADHD effect by upgrading the dopaminergic system and central cholinergic system, inhibiting the inflammatory response and GIRK channel, and exerting a synergistic effect with other drugs on ADHD. For this reason, gastrodin should be considered a multitarget drug for ADHD treatment." @default.
- W4297873120 created "2022-10-01" @default.
- W4297873120 creator A5001660736 @default.
- W4297873120 creator A5043849863 @default.
- W4297873120 creator A5053577672 @default.
- W4297873120 creator A5061255603 @default.
- W4297873120 creator A5073285952 @default.
- W4297873120 date "2022-09-12" @default.
- W4297873120 modified "2023-09-27" @default.
- W4297873120 title "Potential Targets and Action Mechanism of Gastrodin in the Treatment of Attention-Deficit/Hyperactivity Disorder: Bioinformatics and Network Pharmacology Analysis" @default.
- W4297873120 cites W1863452771 @default.
- W4297873120 cites W1983030849 @default.
- W4297873120 cites W1989969076 @default.
- W4297873120 cites W1991801089 @default.
- W4297873120 cites W1991966760 @default.
- W4297873120 cites W1992615559 @default.
- W4297873120 cites W2016511885 @default.
- W4297873120 cites W2048402290 @default.
- W4297873120 cites W2068057675 @default.
- W4297873120 cites W2072679875 @default.
- W4297873120 cites W2094189433 @default.
- W4297873120 cites W2095294450 @default.
- W4297873120 cites W2098273438 @default.
- W4297873120 cites W2107449954 @default.
- W4297873120 cites W2109413825 @default.
- W4297873120 cites W2117104588 @default.
- W4297873120 cites W2120183527 @default.
- W4297873120 cites W2124613981 @default.
- W4297873120 cites W2141611690 @default.
- W4297873120 cites W2146247985 @default.
- W4297873120 cites W2163532037 @default.
- W4297873120 cites W2178940099 @default.
- W4297873120 cites W2235723058 @default.
- W4297873120 cites W2275334170 @default.
- W4297873120 cites W2555939735 @default.
- W4297873120 cites W2583434320 @default.
- W4297873120 cites W2598160886 @default.
- W4297873120 cites W2614669943 @default.
- W4297873120 cites W2802039131 @default.
- W4297873120 cites W2899133544 @default.
- W4297873120 cites W2937918242 @default.
- W4297873120 cites W2946838474 @default.
- W4297873120 cites W2947628883 @default.
- W4297873120 cites W2950373286 @default.
- W4297873120 cites W2956109915 @default.
- W4297873120 cites W2981089015 @default.
- W4297873120 cites W2982148721 @default.
- W4297873120 cites W3039062806 @default.
- W4297873120 cites W3042366596 @default.
- W4297873120 cites W3043662952 @default.
- W4297873120 cites W3044850122 @default.
- W4297873120 cites W3049036781 @default.
- W4297873120 cites W3049701379 @default.
- W4297873120 cites W3098323141 @default.
- W4297873120 cites W3108015116 @default.
- W4297873120 cites W3108843568 @default.
- W4297873120 cites W3119793384 @default.
- W4297873120 cites W3122745243 @default.
- W4297873120 cites W3122870545 @default.
- W4297873120 cites W3124908774 @default.
- W4297873120 cites W3132099480 @default.
- W4297873120 cites W3135961716 @default.
- W4297873120 cites W3150025697 @default.
- W4297873120 cites W3159546660 @default.
- W4297873120 cites W3179034397 @default.
- W4297873120 cites W3195362207 @default.
- W4297873120 cites W3196424958 @default.
- W4297873120 cites W3216370608 @default.
- W4297873120 cites W4205404640 @default.
- W4297873120 cites W4206843931 @default.
- W4297873120 cites W4211026919 @default.
- W4297873120 doi "https://doi.org/10.1155/2022/3607053" @default.
- W4297873120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36133787" @default.
- W4297873120 hasPublicationYear "2022" @default.
- W4297873120 type Work @default.
- W4297873120 citedByCount "2" @default.
- W4297873120 countsByYear W42978731202022 @default.
- W4297873120 countsByYear W42978731202023 @default.
- W4297873120 crossrefType "journal-article" @default.
- W4297873120 hasAuthorship W4297873120A5001660736 @default.
- W4297873120 hasAuthorship W4297873120A5043849863 @default.
- W4297873120 hasAuthorship W4297873120A5053577672 @default.
- W4297873120 hasAuthorship W4297873120A5061255603 @default.
- W4297873120 hasAuthorship W4297873120A5073285952 @default.
- W4297873120 hasBestOaLocation W42978731201 @default.
- W4297873120 hasConcept C104317684 @default.
- W4297873120 hasConcept C142724271 @default.
- W4297873120 hasConcept C150194340 @default.
- W4297873120 hasConcept C152724338 @default.
- W4297873120 hasConcept C155261790 @default.
- W4297873120 hasConcept C162317418 @default.
- W4297873120 hasConcept C185592680 @default.
- W4297873120 hasConcept C188947578 @default.
- W4297873120 hasConcept C204787440 @default.
- W4297873120 hasConcept C2780035454 @default.
- W4297873120 hasConcept C2781248740 @default.
- W4297873120 hasConcept C41008148 @default.
- W4297873120 hasConcept C43617362 @default.