Matches in SemOpenAlex for { <https://semopenalex.org/work/W4297883753> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4297883753 abstract "<p>Phosphoinositides (PIPs) play a key role in regulating key cellular functions. PIPs are enriched with a unique acyl profile composed of stearate and arachidonate at the sn-1 and sn-2 positions, respectively, which is governed by phospholipase As and acyltransferases. Specifically, lysocardiolipin acyltransferase (LYCAT) incorporates stearic acid onto the sn-1 position. Previous work found that LYCAT silencing selectively perturbs the levels and localization of phosphatidylinositol-4,5-bisphosphate, an important precursor for phosphatidylinositol-3,4,5- trisphosphate (PIP3). PIP3 recruits and modulates the effector Akt, which promotes and coordinates cell survival and proliferation. Thus, we hypothesized that LYCAT is important in PIP3- Akt signaling and cell proliferation. Our results show that LYCAT silencing suppresses EGF- stimulated phosphorylation of Akt and select downstream substrates. Further, we observed impaired cell proliferation. Overall, our results suggest that the acyl specificity governed by LYCAT may play a significant role in controlling cell signaling and proliferation, which may have consequences for diseases such as cancer. </p>" @default.
- W4297883753 created "2022-10-01" @default.
- W4297883753 creator A5040804506 @default.
- W4297883753 date "2023-03-28" @default.
- W4297883753 modified "2023-09-28" @default.
- W4297883753 title "The Importance of the Acyltransferase Lycat on PI3K-AKT Signaling and Cancer Cell Proliferation" @default.
- W4297883753 doi "https://doi.org/10.32920/21053395" @default.
- W4297883753 hasPublicationYear "2023" @default.
- W4297883753 type Work @default.
- W4297883753 citedByCount "0" @default.
- W4297883753 crossrefType "posted-content" @default.
- W4297883753 hasAuthorship W4297883753A5040804506 @default.
- W4297883753 hasBestOaLocation W42978837531 @default.
- W4297883753 hasConcept C104317684 @default.
- W4297883753 hasConcept C119056186 @default.
- W4297883753 hasConcept C11960822 @default.
- W4297883753 hasConcept C181199279 @default.
- W4297883753 hasConcept C185592680 @default.
- W4297883753 hasConcept C2775970874 @default.
- W4297883753 hasConcept C2778597717 @default.
- W4297883753 hasConcept C2780610907 @default.
- W4297883753 hasConcept C51785407 @default.
- W4297883753 hasConcept C55493867 @default.
- W4297883753 hasConcept C62112901 @default.
- W4297883753 hasConcept C62478195 @default.
- W4297883753 hasConcept C75217442 @default.
- W4297883753 hasConcept C86554907 @default.
- W4297883753 hasConcept C86803240 @default.
- W4297883753 hasConcept C95444343 @default.
- W4297883753 hasConceptScore W4297883753C104317684 @default.
- W4297883753 hasConceptScore W4297883753C119056186 @default.
- W4297883753 hasConceptScore W4297883753C11960822 @default.
- W4297883753 hasConceptScore W4297883753C181199279 @default.
- W4297883753 hasConceptScore W4297883753C185592680 @default.
- W4297883753 hasConceptScore W4297883753C2775970874 @default.
- W4297883753 hasConceptScore W4297883753C2778597717 @default.
- W4297883753 hasConceptScore W4297883753C2780610907 @default.
- W4297883753 hasConceptScore W4297883753C51785407 @default.
- W4297883753 hasConceptScore W4297883753C55493867 @default.
- W4297883753 hasConceptScore W4297883753C62112901 @default.
- W4297883753 hasConceptScore W4297883753C62478195 @default.
- W4297883753 hasConceptScore W4297883753C75217442 @default.
- W4297883753 hasConceptScore W4297883753C86554907 @default.
- W4297883753 hasConceptScore W4297883753C86803240 @default.
- W4297883753 hasConceptScore W4297883753C95444343 @default.
- W4297883753 hasLocation W42978837531 @default.
- W4297883753 hasLocation W42978837532 @default.
- W4297883753 hasOpenAccess W4297883753 @default.
- W4297883753 hasPrimaryLocation W42978837531 @default.
- W4297883753 hasRelatedWork W2000463265 @default.
- W4297883753 hasRelatedWork W2045005486 @default.
- W4297883753 hasRelatedWork W2050167066 @default.
- W4297883753 hasRelatedWork W2062497077 @default.
- W4297883753 hasRelatedWork W2129091304 @default.
- W4297883753 hasRelatedWork W2167746858 @default.
- W4297883753 hasRelatedWork W2356558710 @default.
- W4297883753 hasRelatedWork W2383906047 @default.
- W4297883753 hasRelatedWork W3029800644 @default.
- W4297883753 hasRelatedWork W3211371810 @default.
- W4297883753 isParatext "false" @default.
- W4297883753 isRetracted "false" @default.
- W4297883753 workType "article" @default.